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The map label for this gene is 28379071

Identifier: 28379071

GI number: 28379071

Start: 2255852

End: 2256301

Strand: Direct

Name: 28379071

Synonym: lp_2528

Alternate gene names: NA

Gene position: 2255852-2256301 (Clockwise)

Preceding gene: 28379068

Following gene: 28379080

Centisome position: 68.19

GC content: 41.33

Gene sequence:

>450_bases
ATGGTTCATGCCAAATCTGATGAGTACGACACGTTTAATAATGAATTATTTTTGAAGGGATTTGAGCTTGTGAATATTCG
CGATATCGATCATTTGACCCTAACCGTTACTGACATTGCACGGTCATTACGGTTTTACCATGAAGTATTTGACCTTCCCA
TTGTGACCTTCGATGGTGACCGTCAAGCTGTCTTAGTGGGTAAACAAAAAATTAACTTTCAGACCACTAACCAGCCACAC
CAACCCATTGCGGCTAAGCCGACACCCGGCAGTGCAGATCTTTGCTTGATTGCGAAGGATAATATTGATGATATTCAGCA
TCACTTAAAGAGTTATTTCGTGGATGTGATTACCGGGCCGGTTGAAAGAACTGGTGCCCACGGAAAGTTGACGTCACTGT
ATGTTCGTGATCCTGATAACAACTTGATTGAAATTAGTAACTATCATTAA

Upstream 100 bases:

>100_bases
TCGATGTCGGCTGCGTTCCAGCAATTGGCACCCAGCCCCGGAGGTCGGCATAGGACGCGCAACGGCTGACGAACAGCAAT
CTAACTGGTACATTTTAATC

Downstream 100 bases:

>100_bases
AAAACACCACAAAGACTAATCATTAAAAACGCCCAGGGCAACTGTTCAGTAACTTGCGAACAACTGCCCTGGGCGTTTTT
TGATCGTTATCTGGATATTT

Product: ring-cleaving dioxygenase (putative)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MVHAKSDEYDTFNNELFLKGFELVNIRDIDHLTLTVTDIARSLRFYHEVFDLPIVTFDGDRQAVLVGKQKINFQTTNQPH
QPIAAKPTPGSADLCLIAKDNIDDIQHHLKSYFVDVITGPVERTGAHGKLTSLYVRDPDNNLIEISNYH

Sequences:

>Translated_149_residues
MVHAKSDEYDTFNNELFLKGFELVNIRDIDHLTLTVTDIARSLRFYHEVFDLPIVTFDGDRQAVLVGKQKINFQTTNQPH
QPIAAKPTPGSADLCLIAKDNIDDIQHHLKSYFVDVITGPVERTGAHGKLTSLYVRDPDNNLIEISNYH
>Mature_149_residues
MVHAKSDEYDTFNNELFLKGFELVNIRDIDHLTLTVTDIARSLRFYHEVFDLPIVTFDGDRQAVLVGKQKINFQTTNQPH
QPIAAKPTPGSADLCLIAKDNIDDIQHHLKSYFVDVITGPVERTGAHGKLTSLYVRDPDNNLIEISNYH

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=123, Percent_Identity=43.9024390243902, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: NA

Molecular weight: Translated: 16917; Mature: 16917

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHAKSDEYDTFNNELFLKGFELVNIRDIDHLTLTVTDIARSLRFYHEVFDLPIVTFDGD
CCCCCCCCCCCCCCEEEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCEEEEECCC
RQAVLVGKQKINFQTTNQPHQPIAAKPTPGSADLCLIAKDNIDDIQHHLKSYFVDVITGP
CEEEEEECEEECEEECCCCCCCEECCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
VERTGAHGKLTSLYVRDPDNNLIEISNYH
HHHCCCCCCEEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MVHAKSDEYDTFNNELFLKGFELVNIRDIDHLTLTVTDIARSLRFYHEVFDLPIVTFDGD
CCCCCCCCCCCCCCEEEEEEEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCEEEEECCC
RQAVLVGKQKINFQTTNQPHQPIAAKPTPGSADLCLIAKDNIDDIQHHLKSYFVDVITGP
CEEEEEECEEECEEECCCCCCCEECCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
VERTGAHGKLTSLYVRDPDNNLIEISNYH
HHHCCCCCCEEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]