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The map label for this gene is accC2 [H]

Identifier: 28378368

GI number: 28378368

Start: 1528332

End: 1529720

Strand: Direct

Name: accC2 [H]

Synonym: lp_1678

Alternate gene names: 28378368

Gene position: 1528332-1529720 (Clockwise)

Preceding gene: 28378367

Following gene: 28378369

Centisome position: 46.2

GC content: 46.36

Gene sequence:

>1389_bases
TTGTTTAAAAAAGTCTTAGTCGCGAACCGTGGTGAAATTGCGGTCCAAGTTATTCGCGCGCTTCATGAGATGGGGATTAA
AGCGGTCGCTGTCTATTCAGTGGCTGATCAGGAGAGCTTATTTGTACATCTGGCTGATGAGGCGGTCTGTATTGGGGCGA
GTCCCGTCAACCAGTCATATTTGAATATGCAAGCAATTATTAGCGCTGCTAATTTGACCGGGTGTCAGGCGATTCATCCA
GGCTACGGCTTTTTATCTGAGAATGCGGAATTTGCCAAAATGTGTGCGGATTGTCAGTTAACGTTTATTGGACCGCGTCC
TGAGGTGATTGACCAGATGGGTGACAAAGAAAATGCCCGGCAGACCATGCAACGATTAGGCGTACCCGTGATTCCCGGCA
GTCCATCGGTGCTTAAGGATGTTGAGGCGGCTATGCAAGCTGCCCATACCTTAGGTTACCCAGTTATGATCAAAGCCGCT
GCTGGGGGTGGCGGTAAGGGGATTCGCGCGGTTAGTAATGATCAAGATTTAGCGAAGGCTTTTCGAACCGCTCAGCAGGA
AGCTCAAGCTTCATACGATGATCATCGGTTGTACTTAGAAAAAATCATTGCCCCGGCGAAGCATATCGAAGTGCAGGTCT
TAGCCGATCAACAGGGGCATGTTATTTATCTACCAGAGCGCGATTGTTCGCTACAACGGAATCATCAAAAAGTGTTAGAG
GAAAGTCCATGTGCGGTCATCACGACTGCTGAACGGACCGAATTGGGACAATTAGTGGCTGACGCAACCAAAAAGTTGGG
TTATACAAATACGGGTACCTATGAGTTTTTAATGGATCAGCAGCATCATTTTTATTTTTTGGAAATGAATACGCGGTTGC
AAGTTGAACATACGGTTACTGAAATGGTAACGGGTATTGAATTGATTAAAGCGCAAGTACAAATTGCAGCTGGTATACCA
TTAAAAATTAAACAGGCGGATGTGAAAATTCATGGTGTTGCCATGGAGTGTCGCTTGAATGCGGAGGATCCGTACCACGA
TTTTCGACCGCAACCTGGAAAAATCACCCGGTTGATCTACCCAATGGGGACACTGGGAGTCCGGATTGATGCTGGTGTGG
TGACTGGTAGCATGATTGCACCGTTTTACGACTCGATGATTGCAAAAATCATTGTTCACGGTATTAATCGGAAGATGGTC
AGTCGCAAGATGCATCGTTGTTTATTGGAATTGACCATCGATGGGGTTCAAACGAACCGGACCTTCTTAGCAGGATTAGT
TGCAGATTCGACTGTTAGCCGTGGTACCTATACCACAGCTTATATCGAACAAGACTTTTTGAAAGGATGGTTAAGTGATG
CCCAAGCGCAAGTTTCAAGCACCCACTGA

Upstream 100 bases:

>100_bases
GTCAAATCGGAACAGGCCATGGCGTGATTACCTGTGCTGGTCGTGAGGTTGTTAGTGCTGATTTAACCTTTGTAATGCAA
GCCTGAAGGAGGTATGGCGA

Downstream 100 bases:

>100_bases
ACGGCAGTTAGCTGTTCGACGGGATAATATCCCAGACGCGTTATTGACGCGCTGTCCAGTTTGTCATGAAGATTGTTATA
CCCAAGATCTCGGTGAATTC

Product: acetyl-CoA carboxylase, biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MFKKVLVANRGEIAVQVIRALHEMGIKAVAVYSVADQESLFVHLADEAVCIGASPVNQSYLNMQAIISAANLTGCQAIHP
GYGFLSENAEFAKMCADCQLTFIGPRPEVIDQMGDKENARQTMQRLGVPVIPGSPSVLKDVEAAMQAAHTLGYPVMIKAA
AGGGGKGIRAVSNDQDLAKAFRTAQQEAQASYDDHRLYLEKIIAPAKHIEVQVLADQQGHVIYLPERDCSLQRNHQKVLE
ESPCAVITTAERTELGQLVADATKKLGYTNTGTYEFLMDQQHHFYFLEMNTRLQVEHTVTEMVTGIELIKAQVQIAAGIP
LKIKQADVKIHGVAMECRLNAEDPYHDFRPQPGKITRLIYPMGTLGVRIDAGVVTGSMIAPFYDSMIAKIIVHGINRKMV
SRKMHRCLLELTIDGVQTNRTFLAGLVADSTVSRGTYTTAYIEQDFLKGWLSDAQAQVSSTH

Sequences:

>Translated_462_residues
MFKKVLVANRGEIAVQVIRALHEMGIKAVAVYSVADQESLFVHLADEAVCIGASPVNQSYLNMQAIISAANLTGCQAIHP
GYGFLSENAEFAKMCADCQLTFIGPRPEVIDQMGDKENARQTMQRLGVPVIPGSPSVLKDVEAAMQAAHTLGYPVMIKAA
AGGGGKGIRAVSNDQDLAKAFRTAQQEAQASYDDHRLYLEKIIAPAKHIEVQVLADQQGHVIYLPERDCSLQRNHQKVLE
ESPCAVITTAERTELGQLVADATKKLGYTNTGTYEFLMDQQHHFYFLEMNTRLQVEHTVTEMVTGIELIKAQVQIAAGIP
LKIKQADVKIHGVAMECRLNAEDPYHDFRPQPGKITRLIYPMGTLGVRIDAGVVTGSMIAPFYDSMIAKIIVHGINRKMV
SRKMHRCLLELTIDGVQTNRTFLAGLVADSTVSRGTYTTAYIEQDFLKGWLSDAQAQVSSTH
>Mature_462_residues
MFKKVLVANRGEIAVQVIRALHEMGIKAVAVYSVADQESLFVHLADEAVCIGASPVNQSYLNMQAIISAANLTGCQAIHP
GYGFLSENAEFAKMCADCQLTFIGPRPEVIDQMGDKENARQTMQRLGVPVIPGSPSVLKDVEAAMQAAHTLGYPVMIKAA
AGGGGKGIRAVSNDQDLAKAFRTAQQEAQASYDDHRLYLEKIIAPAKHIEVQVLADQQGHVIYLPERDCSLQRNHQKVLE
ESPCAVITTAERTELGQLVADATKKLGYTNTGTYEFLMDQQHHFYFLEMNTRLQVEHTVTEMVTGIELIKAQVQIAAGIP
LKIKQADVKIHGVAMECRLNAEDPYHDFRPQPGKITRLIYPMGTLGVRIDAGVVTGSMIAPFYDSMIAKIIVHGINRKMV
SRKMHRCLLELTIDGVQTNRTFLAGLVADSTVSRGTYTTAYIEQDFLKGWLSDAQAQVSSTH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=45.5555555555556, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI189095269, Length=450, Percent_Identity=45.5555555555556, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=45.5555555555556, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=43.7641723356009, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=43.4298440979955, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=43.4298440979955, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=43.4298440979955, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=32.0158102766798, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=32.0158102766798, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=32.0158102766798, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=32.0158102766798, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=32.0158102766798, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=30.7992202729045, Blast_Score=233, Evalue=4e-61,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=49.4407158836689, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567343, Length=450, Percent_Identity=43.5555555555556, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=42.6303854875283, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=42.350332594235, Blast_Score=344, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=29.7244094488189, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=29.7244094488189, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=28.1314168377823, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=42.2727272727273, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=43.2071269487751, Blast_Score=352, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=42.9844097995546, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6323863, Length=473, Percent_Identity=32.76955602537, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=30.8429118773946, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=41.4414414414414, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=41.2946428571429, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=40.6862745098039, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=30.2605210420842, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=30.2605210420842, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=30.2605210420842, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=30.2605210420842, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50708; Mature: 50708

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKVLVANRGEIAVQVIRALHEMGIKAVAVYSVADQESLFVHLADEAVCIGASPVNQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCEEEECCCCCCHHH
LNMQAIISAANLTGCQAIHPGYGFLSENAEFAKMCADCQLTFIGPRPEVIDQMGDKENAR
HHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHCCCEEEEECCCHHHHHHCCCHHHHH
QTMQRLGVPVIPGSPSVLKDVEAAMQAAHTLGYPVMIKAAAGGGGKGIRAVSNDQDLAKA
HHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCHHHHHH
FRTAQQEAQASYDDHRLYLEKIIAPAKHIEVQVLADQQGHVIYLPERDCSLQRNHQKVLE
HHHHHHHHHCCCCHHHHHHHHHHCCHHHEEEEEEECCCCCEEEECCCCCCCHHHHHHHHH
ESPCAVITTAERTELGQLVADATKKLGYTNTGTYEFLMDQQHHFYFLEMNTRLQVEHTVT
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEEEEHHHHH
EMVTGIELIKAQVQIAAGIPLKIKQADVKIHGVAMECRLNAEDPYHDFRPQPGKITRLIY
HHHHHHHHHHHHHHEECCCCEEEEECCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEE
PMGTLGVRIDAGVVTGSMIAPFYDSMIAKIIVHGINRKMVSRKMHRCLLELTIDGVQTNR
ECCCCCEEEECCEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCC
TFLAGLVADSTVSRGTYTTAYIEQDFLKGWLSDAQAQVSSTH
HHEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFKKVLVANRGEIAVQVIRALHEMGIKAVAVYSVADQESLFVHLADEAVCIGASPVNQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCEEEECCCCCCHHH
LNMQAIISAANLTGCQAIHPGYGFLSENAEFAKMCADCQLTFIGPRPEVIDQMGDKENAR
HHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHCCCEEEEECCCHHHHHHCCCHHHHH
QTMQRLGVPVIPGSPSVLKDVEAAMQAAHTLGYPVMIKAAAGGGGKGIRAVSNDQDLAKA
HHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCHHHHHH
FRTAQQEAQASYDDHRLYLEKIIAPAKHIEVQVLADQQGHVIYLPERDCSLQRNHQKVLE
HHHHHHHHHCCCCHHHHHHHHHHCCHHHEEEEEEECCCCCEEEECCCCCCCHHHHHHHHH
ESPCAVITTAERTELGQLVADATKKLGYTNTGTYEFLMDQQHHFYFLEMNTRLQVEHTVT
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEEEEHHHHH
EMVTGIELIKAQVQIAAGIPLKIKQADVKIHGVAMECRLNAEDPYHDFRPQPGKITRLIY
HHHHHHHHHHHHHHEECCCCEEEEECCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEE
PMGTLGVRIDAGVVTGSMIAPFYDSMIAKIIVHGINRKMVSRKMHRCLLELTIDGVQTNR
ECCCCCEEEECCEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCC
TFLAGLVADSTVSRGTYTTAYIEQDFLKGWLSDAQAQVSSTH
HHEEHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]