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The map label for this gene is fabZ1

Identifier: 28378360

GI number: 28378360

Start: 1522735

End: 1523178

Strand: Direct

Name: fabZ1

Synonym: lp_1670

Alternate gene names: 28378360

Gene position: 1522735-1523178 (Clockwise)

Preceding gene: 28378359

Following gene: 28378361

Centisome position: 46.03

GC content: 46.17

Gene sequence:

>444_bases
ATGAGTGTGTTAGAAGCAAGTGAAATTATGCAATTAATCCCCAACCGGTACCCAATTTTATTCATGGACCGGGTGGATGA
ATTAAATCCGGGTGAATCGATCGTGGTGACGAAAAATGTCACGATTAATGAGTCATTTTTCCAAGGGCACTTTCCCGGTA
ACCCGGTCATGCCGGGCGTGTTGATTATTGAAGCTTTGGCGCAAGCCGCGTCGATTCTGATTTTGAAATCTGAAAAGTTT
GCTGGTAAGACGGCTTATCTTGGCGCCATTAAGGATGCCAAGTTCCGCAAAATTGTCCGTCCCGGTGATGTCTTGAAGTT
GCATGTCCAAATGGTCAAGCAACGGTCCAACATGGGAACGGTGAGTTGTCAGGCGATGGTCGGTGACAAGGCAGCCTGCA
CAACTGATTTAACCTTTATCGTTGGTGCAACTGATTCAAAATAG

Upstream 100 bases:

>100_bases
GTAACATACTGTAAATTAATCTGCTGAAATCAATTGACAAGATTTGGCCGGACGATTAACTTAATGCCATTCCCAAACGC
CGTGAAAGGAGCGACTAACT

Downstream 100 bases:

>100_bases
AAAGGTGGTAATGGCAATTCGGCGATTGTCGTTTGGGAAAGTTTTTTAAAAGTATTGCCGAATTGTAACCAACCATGACA
ACTAATTTTTCGATTTTAGC

Product: (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase

Products: NA

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MSVLEASEIMQLIPNRYPILFMDRVDELNPGESIVVTKNVTINESFFQGHFPGNPVMPGVLIIEALAQAASILILKSEKF
AGKTAYLGAIKDAKFRKIVRPGDVLKLHVQMVKQRSNMGTVSCQAMVGDKAACTTDLTFIVGATDSK

Sequences:

>Translated_147_residues
MSVLEASEIMQLIPNRYPILFMDRVDELNPGESIVVTKNVTINESFFQGHFPGNPVMPGVLIIEALAQAASILILKSEKF
AGKTAYLGAIKDAKFRKIVRPGDVLKLHVQMVKQRSNMGTVSCQAMVGDKAACTTDLTFIVGATDSK
>Mature_146_residues
SVLEASEIMQLIPNRYPILFMDRVDELNPGESIVVTKNVTINESFFQGHFPGNPVMPGVLIIEALAQAASILILKSEKFA
GKTAYLGAIKDAKFRKIVRPGDVLKLHVQMVKQRSNMGTVSCQAMVGDKAACTTDLTFIVGATDSK

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=132, Percent_Identity=42.4242424242424, Blast_Score=116, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_LACPL (Q88WG9)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785252.1
- ProteinModelPortal:   Q88WG9
- SMR:   Q88WG9
- GeneID:   1061766
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1670
- NMPDR:   fig|220668.1.peg.1386
- HOGENOM:   HBG433282
- OMA:   AELTFIV
- ProtClustDB:   CLSK912452
- BioCyc:   LPLA220668:LP_1670-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.-

Molecular weight: Translated: 15998; Mature: 15867

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: ACT_SITE 50-50

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLEASEIMQLIPNRYPILFMDRVDELNPGESIVVTKNVTINESFFQGHFPGNPVMPGV
CCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECEEECHHHEECCCCCCCCCCHH
LIIEALAQAASILILKSEKFAGKTAYLGAIKDAKFRKIVRPGDVLKLHVQMVKQRSNMGT
HHHHHHHHHHEEEEEECCCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
VSCQAMVGDKAACTTDLTFIVGATDSK
EEEEEEECCCCCCEECEEEEEECCCCC
>Mature Secondary Structure 
SVLEASEIMQLIPNRYPILFMDRVDELNPGESIVVTKNVTINESFFQGHFPGNPVMPGV
CCCCHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECEEECHHHEECCCCCCCCCCHH
LIIEALAQAASILILKSEKFAGKTAYLGAIKDAKFRKIVRPGDVLKLHVQMVKQRSNMGT
HHHHHHHHHHEEEEEECCCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
VSCQAMVGDKAACTTDLTFIVGATDSK
EEEEEEECCCCCCEECEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566