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The map label for this gene is trpC

Identifier: 28378347

GI number: 28378347

Start: 1509819

End: 1510601

Strand: Direct

Name: trpC

Synonym: lp_1655

Alternate gene names: 28378347

Gene position: 1509819-1510601 (Clockwise)

Preceding gene: 28378346

Following gene: 28378348

Centisome position: 45.64

GC content: 48.91

Gene sequence:

>783_bases
ATGATTTTAGATCAACTCGTCCAGGCGAGTCAGCAACGGGTTCAGAAGGTGCCAGTTAGGGAGCGTGTGAAGCGCATTCA
ACAAGCTCGAAAAATGACCACCCCCGTTTTATCATTTGAAGCAATGCTGGCCCAGCCGGGCTTACAGCTTATTGGTGAAG
TTAAGCGGGCGTCACCTTCTAAGGGGCTGATTGCGGCTGAGTTTGACTATTTACAGATTGCGCAAGACTATGTTGCTGCT
GGGATCGATGCCATCTCAGTGTTGACCGAACCCCGGTATTTTAAAGGACAGTTGTCTTACTTACAAGCCATTACGCAAAC
GGTCTCGGTACCCACATTACGTAAAGATTTTATTGTGGCTGCTAGTCAGATTGCGAGTGCTCGTATTGCTGGTGCTAGTG
CGGTTTTATTGATTGTTGCTATTTTAACACCGGTTCAACTGCAGGCTTTCATTACGTTGGCTCATGAGCTGAATTTAAGT
GCGCTAGTTGAAGTCCATACAACGGCTGAGAGTAAGCAAGCGGTGGCGGCTGGGGCCCGGATTATTGGCATTAATAATCG
GAATTTGAAAGATTTCAGTGTCAATTTTGCAACGAGCTGTCAGTTACGGCAAGCAGTTCCAGCTGAGTGTTATGTGGTCG
CTGAGTCTGGTATTCAAACGGCCACACAGGCTCAACAGTTGGCCGCTGCTGGCTTTGACGCCATGCTAGTTGGCGAAACA
TTGATGCGTGCACCAGATAAAGGTCAAGCCGTCATGCAATTGCGGGCGGGGGTGCGTGGATGA

Upstream 100 bases:

>100_bases
TAGCGGCCGCTTTTGAGTTGGCCCAGCAAACAATCGATCAAGGAGCGGCCGCGGCTAAGTTGGCCCAATTAATTCAGAGT
AGTCAGGCGGTGATGGCCTC

Downstream 100 bases:

>100_bases
CTCAAATCAAAATTTGTGGCTTAATGCGACCAGCGGATGTCGTGATGGTTAATCAAGCGCTCCCAGACGCAATTGGGATG
GTATTTGCCCCCGGTCGTCG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPSKGLIAAEFDYLQIAQDYVAA
GIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVAASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLS
ALVEVHTTAESKQAVAAGARIIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGET
LMRAPDKGQAVMQLRAGVRG

Sequences:

>Translated_260_residues
MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPSKGLIAAEFDYLQIAQDYVAA
GIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVAASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLS
ALVEVHTTAESKQAVAAGARIIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGET
LMRAPDKGQAVMQLRAGVRG
>Mature_260_residues
MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPSKGLIAAEFDYLQIAQDYVAA
GIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVAASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLS
ALVEVHTTAESKQAVAAGARIIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGET
LMRAPDKGQAVMQLRAGVRG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=244, Percent_Identity=36.4754098360656, Blast_Score=137, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=38.0281690140845, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_LACPL (Q88WI2)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785239.1
- ProteinModelPortal:   Q88WI2
- SMR:   Q88WI2
- GeneID:   1062151
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1655
- NMPDR:   fig|220668.1.peg.1373
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   CLSK2520242
- BioCyc:   LPLA220668:LP_1655-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27913; Mature: 27913

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCC
KGLIAAEFDYLQIAQDYVAAGIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVA
CCEEEECHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLSALVEVHTTAESKQAVAAGAR
HHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHEEEEHHCHHHHHHHHCCEE
IIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGET
EEECCCCCCCEEEECHHHCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHH
LMRAPDKGQAVMQLRAGVRG
HHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCC
KGLIAAEFDYLQIAQDYVAAGIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVA
CCEEEECHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLSALVEVHTTAESKQAVAAGAR
HHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHEEEEHHCHHHHHHHHCCEE
IIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGET
EEECCCCCCCEEEECHHHCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHH
LMRAPDKGQAVMQLRAGVRG
HHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566