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The map label for this gene is trpF

Identifier: 28378348

GI number: 28378348

Start: 1510598

End: 1511224

Strand: Direct

Name: trpF

Synonym: lp_1656

Alternate gene names: 28378348

Gene position: 1510598-1511224 (Clockwise)

Preceding gene: 28378347

Following gene: 28378349

Centisome position: 45.66

GC content: 50.08

Gene sequence:

>627_bases
ATGACTCAAATCAAAATTTGTGGCTTAATGCGACCAGCGGATGTCGTGATGGTTAATCAAGCGCTCCCAGACGCAATTGG
GATGGTATTTGCCCCCGGTCGTCGACGACGGATTACGATGGCGACCGCGCGCCAACTGTCACAGCAATTAGATCCGCGTA
TCCGGCGTGTTGGCGTGTTTACAACTAATCAATTATCGGAAATTTTAGCTCTCGTGCAACAGCACATTATTCAGGTGGTC
CAGCTACACGCTACCGTCGATGATCCTCGGATTGCGTCCTTAATGGCCGCCCACGTGCCGGTGATTCAAGCGATGACGCC
AGCGAATGCTACGCAATGTCAAGCGGATTACTTATTATTGGATAATGCCCGTCCAGGTAGTGGACAGGTGTTGGATTGGA
ATCAATTACAATCACAGCGTCCCGTCCGGCCGTTTATCTTGGCTGGTGGTTTAACACCGACGAATATCGTAACGGCAATC
AACAAGGTATACCCGGCAATGGTCGATGTGGCTAGTGGCGTCGAGACGGCGGGCAATAAAGACCGTGAAAAAATCAATCT
AATGGTCCAACGGGCGCACCAAACGGGCGTGTCAACACCATTATTAACAGAAATTAGGAGGAATTAG

Upstream 100 bases:

>100_bases
TGGCCGCTGCTGGCTTTGACGCCATGCTAGTTGGCGAAACATTGATGCGTGCACCAGATAAAGGTCAAGCCGTCATGCAA
TTGCGGGCGGGGGTGCGTGG

Downstream 100 bases:

>100_bases
TATGATTAAAAATCAATCACAGGCGGGGCGTTACGGCGACTTTGGTGGTCAGTACGTTCCAGAAACATTAATGACCGAGC
TACAGCGGTTGGATCGCGCC

Product: phosphorybosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTQIKICGLMRPADVVMVNQALPDAIGMVFAPGRRRRITMATARQLSQQLDPRIRRVGVFTTNQLSEILALVQQHIIQVV
QLHATVDDPRIASLMAAHVPVIQAMTPANATQCQADYLLLDNARPGSGQVLDWNQLQSQRPVRPFILAGGLTPTNIVTAI
NKVYPAMVDVASGVETAGNKDREKINLMVQRAHQTGVSTPLLTEIRRN

Sequences:

>Translated_208_residues
MTQIKICGLMRPADVVMVNQALPDAIGMVFAPGRRRRITMATARQLSQQLDPRIRRVGVFTTNQLSEILALVQQHIIQVV
QLHATVDDPRIASLMAAHVPVIQAMTPANATQCQADYLLLDNARPGSGQVLDWNQLQSQRPVRPFILAGGLTPTNIVTAI
NKVYPAMVDVASGVETAGNKDREKINLMVQRAHQTGVSTPLLTEIRRN
>Mature_207_residues
TQIKICGLMRPADVVMVNQALPDAIGMVFAPGRRRRITMATARQLSQQLDPRIRRVGVFTTNQLSEILALVQQHIIQVVQ
LHATVDDPRIASLMAAHVPVIQAMTPANATQCQADYLLLDNARPGSGQVLDWNQLQSQRPVRPFILAGGLTPTNIVTAIN
KVYPAMVDVASGVETAGNKDREKINLMVQRAHQTGVSTPLLTEIRRN

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Saccharomyces cerevisiae, GI6320210, Length=213, Percent_Identity=30.9859154929577, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_LACPL (Q88WI1)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785240.1
- ProteinModelPortal:   Q88WI1
- SMR:   Q88WI1
- GeneID:   1061516
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1656
- NMPDR:   fig|220668.1.peg.1374
- HOGENOM:   HBG554803
- OMA:   ETTGITS
- ProtClustDB:   CLSK2520243
- BioCyc:   LPLA220668:LP_1656-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22828; Mature: 22697

Theoretical pI: Translated: 10.80; Mature: 10.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIKICGLMRPADVVMVNQALPDAIGMVFAPGRRRRITMATARQLSQQLDPRIRRVGVF
CCEEEEECCCCCCCEEEECHHCCHHHHHEECCCCCCEEHHHHHHHHHHHHCHHHHHCCCC
TTNQLSEILALVQQHIIQVVQLHATVDDPRIASLMAAHVPVIQAMTPANATQCQADYLLL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
DNARPGSGQVLDWNQLQSQRPVRPFILAGGLTPTNIVTAINKVYPAMVDVASGVETAGNK
ECCCCCCCCEEEHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCC
DREKINLMVQRAHQTGVSTPLLTEIRRN
HHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TQIKICGLMRPADVVMVNQALPDAIGMVFAPGRRRRITMATARQLSQQLDPRIRRVGVF
CEEEEECCCCCCCEEEECHHCCHHHHHEECCCCCCEEHHHHHHHHHHHHCHHHHHCCCC
TTNQLSEILALVQQHIIQVVQLHATVDDPRIASLMAAHVPVIQAMTPANATQCQADYLLL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
DNARPGSGQVLDWNQLQSQRPVRPFILAGGLTPTNIVTAINKVYPAMVDVASGVETAGNK
ECCCCCCCCEEEHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCC
DREKINLMVQRAHQTGVSTPLLTEIRRN
HHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566