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The map label for this gene is trpD

Identifier: 28378346

GI number: 28378346

Start: 1508803

End: 1509822

Strand: Direct

Name: trpD

Synonym: lp_1654

Alternate gene names: 28378346

Gene position: 1508803-1509822 (Clockwise)

Preceding gene: 28378345

Following gene: 28378347

Centisome position: 45.61

GC content: 51.18

Gene sequence:

>1020_bases
ATGATTGAAACAGCGATTGCACAACTCACTAACCAAGAAAATCTAGACTTTACAATGAGCCAACAAGTCATTACGGAAAT
TATGAAAGGTCAGGCCACCGACGCACAGATTGGGAGCTTTTTGACCGCCTTAGCCATCAAAAAGGCAACTATCGATGAAA
TTGCTGGTGCAGCAACTGCGATGCGTTCCCAGGCGTTACCTTTTAAAGTTAAACGGCCCACGCTAGAAATCGTTGGGACG
GGCGGTGACCGGTCGAATTCGTTTAATATTTCGACGACCACTGCGCTAGTGGTCGCTGCTGCGGGTGTACCAGTGACCAA
GCACGGCAATCGTGCGGCGTCGTCCAAGAGTGGTGCGGCGGATGTTTTAGAAGCACTCGGTATCAAAATCGATCTAACGC
CCGCTCAGAGTCTAGCATTGCTAGAGCGGACCAATTTTGCCTTTATGTATGCGCGCGAATATCATCAGGCGATGCGATTT
GTCGCTCCGGCTCGGCAACAAATCAAGATTCCAACTATTTTTAATATACTGGGTCCCTTAGCCAACCCAGCTCATGCTGA
GATGCAACTATTAGGGGTATACCGGCAAGCTTTAATGGCTCCATTAGCCGAAGTGTTGACGCGTTTAGGTGTTAAACATG
CCATGGTCGTGCATAGCCGAGACGGCTTAGATGAAATTTCAGCGGCAGCCCCTACGGATGTGATCGTAATTAATCATGGG
CAGCAAGTAACGCGAATCCTGACGCCTGAACAGTTTGGACTGACGCGTTGTGACCATGCGGCTCTTATTGGTGGTAGTGC
CCAAGTTAATGCCGCCATCACGCGGGCAGTACTCACTGGAGAACCGGGGGCCCCTCGTGACGTGGTGTTGATGAATGCCG
CCGCGGCGTTGCATATTGCCAAGCCACAGTTGGATCTAGCGGCCGCTTTTGAGTTGGCCCAGCAAACAATCGATCAAGGA
GCGGCCGCGGCTAAGTTGGCCCAATTAATTCAGAGTAGTCAGGCGGTGATGGCCTCATGA

Upstream 100 bases:

>100_bases
TCATCCAGAATCAATCATGACGCCAGCCGCCGTTGGTGAGCAACTGATCCGTAATTTTTTAGCACTTAAACATTAAGCAG
ACGAGAGTGGAGGAATACTT

Downstream 100 bases:

>100_bases
TTTTAGATCAACTCGTCCAGGCGAGTCAGCAACGGGTTCAGAAGGTGCCAGTTAGGGAGCGTGTGAAGCGCATTCAACAA
GCTCGAAAAATGACCACCCC

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIETAIAQLTNQENLDFTMSQQVITEIMKGQATDAQIGSFLTALAIKKATIDEIAGAATAMRSQALPFKVKRPTLEIVGT
GGDRSNSFNISTTTALVVAAAGVPVTKHGNRAASSKSGAADVLEALGIKIDLTPAQSLALLERTNFAFMYAREYHQAMRF
VAPARQQIKIPTIFNILGPLANPAHAEMQLLGVYRQALMAPLAEVLTRLGVKHAMVVHSRDGLDEISAAAPTDVIVINHG
QQVTRILTPEQFGLTRCDHAALIGGSAQVNAAITRAVLTGEPGAPRDVVLMNAAAALHIAKPQLDLAAAFELAQQTIDQG
AAAAKLAQLIQSSQAVMAS

Sequences:

>Translated_339_residues
MIETAIAQLTNQENLDFTMSQQVITEIMKGQATDAQIGSFLTALAIKKATIDEIAGAATAMRSQALPFKVKRPTLEIVGT
GGDRSNSFNISTTTALVVAAAGVPVTKHGNRAASSKSGAADVLEALGIKIDLTPAQSLALLERTNFAFMYAREYHQAMRF
VAPARQQIKIPTIFNILGPLANPAHAEMQLLGVYRQALMAPLAEVLTRLGVKHAMVVHSRDGLDEISAAAPTDVIVINHG
QQVTRILTPEQFGLTRCDHAALIGGSAQVNAAITRAVLTGEPGAPRDVVLMNAAAALHIAKPQLDLAAAFELAQQTIDQG
AAAAKLAQLIQSSQAVMAS
>Mature_339_residues
MIETAIAQLTNQENLDFTMSQQVITEIMKGQATDAQIGSFLTALAIKKATIDEIAGAATAMRSQALPFKVKRPTLEIVGT
GGDRSNSFNISTTTALVVAAAGVPVTKHGNRAASSKSGAADVLEALGIKIDLTPAQSLALLERTNFAFMYAREYHQAMRF
VAPARQQIKIPTIFNILGPLANPAHAEMQLLGVYRQALMAPLAEVLTRLGVKHAMVVHSRDGLDEISAAAPTDVIVINHG
QQVTRILTPEQFGLTRCDHAALIGGSAQVNAAITRAVLTGEPGAPRDVVLMNAAAALHIAKPQLDLAAAFELAQQTIDQG
AAAAKLAQLIQSSQAVMAS

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=283, Percent_Identity=42.0494699646643, Blast_Score=201, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320561, Length=326, Percent_Identity=31.5950920245399, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_LACPL (Q88WI3)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785238.1
- ProteinModelPortal:   Q88WI3
- SMR:   Q88WI3
- GeneID:   1062154
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1654
- NMPDR:   fig|220668.1.peg.1372
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- ProtClustDB:   CLSK2520241
- BioCyc:   LPLA220668:LP_1654-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 35697; Mature: 35697

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETAIAQLTNQENLDFTMSQQVITEIMKGQATDAQIGSFLTALAIKKATIDEIAGAATA
CCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRSQALPFKVKRPTLEIVGTGGDRSNSFNISTTTALVVAAAGVPVTKHGNRAASSKSGAA
HHHCCCCEEECCCEEEEEECCCCCCCCEEEHHHHHHHHHCCCCCEECCCCCCCCCCCCHH
DVLEALGIKIDLTPAQSLALLERTNFAFMYAREYHQAMRFVAPARQQIKIPTIFNILGPL
HHHHHHCCEEEECCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHEECHHHHHHHHCC
ANPAHAEMQLLGVYRQALMAPLAEVLTRLGVKHAMVVHSRDGLDEISAAAPTDVIVINHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHCCCCCEEEEECC
QQVTRILTPEQFGLTRCDHAALIGGSAQVNAAITRAVLTGEPGAPRDVVLMNAAAALHIA
CHHHHCCCCHHHCCCCCCCCEEECCCCHHHHHHHHHEEECCCCCCCCEEEEEHHHHEEEC
KPQLDLAAAFELAQQTIDQGAAAAKLAQLIQSSQAVMAS
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIETAIAQLTNQENLDFTMSQQVITEIMKGQATDAQIGSFLTALAIKKATIDEIAGAATA
CCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRSQALPFKVKRPTLEIVGTGGDRSNSFNISTTTALVVAAAGVPVTKHGNRAASSKSGAA
HHHCCCCEEECCCEEEEEECCCCCCCCEEEHHHHHHHHHCCCCCEECCCCCCCCCCCCHH
DVLEALGIKIDLTPAQSLALLERTNFAFMYAREYHQAMRFVAPARQQIKIPTIFNILGPL
HHHHHHCCEEEECCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHEECHHHHHHHHCC
ANPAHAEMQLLGVYRQALMAPLAEVLTRLGVKHAMVVHSRDGLDEISAAAPTDVIVINHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHCCCCCEEEEECC
QQVTRILTPEQFGLTRCDHAALIGGSAQVNAAITRAVLTGEPGAPRDVVLMNAAAALHIA
CHHHHCCCCHHHCCCCCCCCEEECCCCHHHHHHHHHEEECCCCCCCCEEEEEHHHHEEEC
KPQLDLAAAFELAQQTIDQGAAAAKLAQLIQSSQAVMAS
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566