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The map label for this gene is ffh [H]

Identifier: 28378333

GI number: 28378333

Start: 1490888

End: 1492342

Strand: Direct

Name: ffh [H]

Synonym: lp_1635

Alternate gene names: 28378333

Gene position: 1490888-1492342 (Clockwise)

Preceding gene: 28378332

Following gene: 28378334

Centisome position: 45.07

GC content: 47.01

Gene sequence:

>1455_bases
ATGGCATTTGAAGGCCTAACGGAACGTTTACAAAAAGCAATGACCAATTTACGGCGCAAGGGGAAGATTTCGGAAAGTGA
TCTTCGAGCAACCATGCGTGAAATTCGGTTAGCATTACTTGAAGCCGACGTTAACTTTACGGTGGTCAAGGATTTTGTTA
AAACGGTTCGCGAACGTGCGCTCGGCGCAAAGGTGCTGGAAGGTTTAAATCCAGCCCAACAAATCGTTAAAATCGTTGAT
GAAGAATTAACGAAAACAATGGGTGAAAAGGCAGTTCCACTGAACAAATCGCCGAAGATTCCAACGGTCATCATGATGGC
TGGGCTCCAAGGGGCCGGGAAAACGACGACGGTCGGAAAATTAGCCCTCAAATTAAAGAACGAACAGGATGCCCGACCAT
TAATGATTGCGGCCGACGTTTACCGGCCAGCCGCGATTGAACAATTGCAACAAGTTGGTCGCCAAATCGACGTTCCAGTC
TTCCAACTAGGAACCGATGTCGATCCCGTTGAGATTGTGCGTCAAGGGATGGCACAGGCGAAAGAAAACCACAATGATTA
CGTGTTTATTGATACGGCTGGTCGGTTACAAATCGATGAGCAGTTGATGAACGAGTTGGCCAATATTAAAGATCTCGTTC
ATCCTGACGAAATTTTGTTAGTGATCGATGCGATGACTGGTCAAAACGCCGTTAATACGGCGGAGGGCTTTAACGATAAG
CTGGATGTGACCGGGGTCGTCTTGACGAAGTTAGATGGTGATACTCGTGGTGGGGCTGCACTATCAATTCGGGCCGTCAC
TGGTAAGCCAATCAAGTTTGTCGGTCAAGGCGAAAAGATGACTGATCTTGATGTCTTCCATCCAGACCGGATGGCGGATC
GGATTCTTGGCATGGGTGATATGCTGACGCTGATTGAAAAGGCGCAACAGCAATATGACGAAAAACAAGCCGAAGAAATG
AACCTGAAGATTCAGGAAAACACTTTTGACTTCAATGACTTTATCGACCAATTAGACCAAGTTGACAAGATGGGGAACAT
GGAAGATATCATGAAGATGATTCCCGGCATGGCTAACAATCCAGCGATGAAAAATATCAACATGGACCCGAAAGACATTG
CCCATATCCGGGCAATCGTTTATTCGATGACCAATGCCGAAAAAGCAGATCCGGATTTGTTGAACCCATCTCGGCGTCGA
CGGATTGCGGCTGGTTCCGGGCGGCCAATTCATGAAGTCAACCGGATGATCAAGCAATTCAACCAGACCAAAAAGATGAT
GAATCAAATGTCCAAAGGGAACTTTGCTGGTATGGAAGGTCTCATGGGTGGTGCCAATGGCGGTGGCGGTATCGGTGGTA
AGATGCAACAAATGGCCATGAAGCGAATGGTTCGTCAAACTAAGAAGAAAAAACAAAAGCGCTTAGCCAAAGCAATGCGG
CGTCGCAAACGCTAA

Upstream 100 bases:

>100_bases
AAGCAAAATTACCATGGGGATACCCAGTTAATTAAGATGATTCAACAACTAGTCAACTTGGAAGCTGACTCAGAATAATA
ATAAAGGTTAGGTGACACTA

Downstream 100 bases:

>100_bases
TTTATAAGTTTTTTTAGCCTGTCAAGAAAAAGTCCTTTACAAGCTATTGATTTACTGGTATATTATTACCTGTTAAAGAA
TTCGGGAGGTGTTTAAATGT

Product: signal recognition particle protein Ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAFEGLTERLQKAMTNLRRKGKISESDLRATMREIRLALLEADVNFTVVKDFVKTVRERALGAKVLEGLNPAQQIVKIVD
EELTKTMGEKAVPLNKSPKIPTVIMMAGLQGAGKTTTVGKLALKLKNEQDARPLMIAADVYRPAAIEQLQQVGRQIDVPV
FQLGTDVDPVEIVRQGMAQAKENHNDYVFIDTAGRLQIDEQLMNELANIKDLVHPDEILLVIDAMTGQNAVNTAEGFNDK
LDVTGVVLTKLDGDTRGGAALSIRAVTGKPIKFVGQGEKMTDLDVFHPDRMADRILGMGDMLTLIEKAQQQYDEKQAEEM
NLKIQENTFDFNDFIDQLDQVDKMGNMEDIMKMIPGMANNPAMKNINMDPKDIAHIRAIVYSMTNAEKADPDLLNPSRRR
RIAAGSGRPIHEVNRMIKQFNQTKKMMNQMSKGNFAGMEGLMGGANGGGGIGGKMQQMAMKRMVRQTKKKKQKRLAKAMR
RRKR

Sequences:

>Translated_484_residues
MAFEGLTERLQKAMTNLRRKGKISESDLRATMREIRLALLEADVNFTVVKDFVKTVRERALGAKVLEGLNPAQQIVKIVD
EELTKTMGEKAVPLNKSPKIPTVIMMAGLQGAGKTTTVGKLALKLKNEQDARPLMIAADVYRPAAIEQLQQVGRQIDVPV
FQLGTDVDPVEIVRQGMAQAKENHNDYVFIDTAGRLQIDEQLMNELANIKDLVHPDEILLVIDAMTGQNAVNTAEGFNDK
LDVTGVVLTKLDGDTRGGAALSIRAVTGKPIKFVGQGEKMTDLDVFHPDRMADRILGMGDMLTLIEKAQQQYDEKQAEEM
NLKIQENTFDFNDFIDQLDQVDKMGNMEDIMKMIPGMANNPAMKNINMDPKDIAHIRAIVYSMTNAEKADPDLLNPSRRR
RIAAGSGRPIHEVNRMIKQFNQTKKMMNQMSKGNFAGMEGLMGGANGGGGIGGKMQQMAMKRMVRQTKKKKQKRLAKAMR
RRKR
>Mature_483_residues
AFEGLTERLQKAMTNLRRKGKISESDLRATMREIRLALLEADVNFTVVKDFVKTVRERALGAKVLEGLNPAQQIVKIVDE
ELTKTMGEKAVPLNKSPKIPTVIMMAGLQGAGKTTTVGKLALKLKNEQDARPLMIAADVYRPAAIEQLQQVGRQIDVPVF
QLGTDVDPVEIVRQGMAQAKENHNDYVFIDTAGRLQIDEQLMNELANIKDLVHPDEILLVIDAMTGQNAVNTAEGFNDKL
DVTGVVLTKLDGDTRGGAALSIRAVTGKPIKFVGQGEKMTDLDVFHPDRMADRILGMGDMLTLIEKAQQQYDEKQAEEMN
LKIQENTFDFNDFIDQLDQVDKMGNMEDIMKMIPGMANNPAMKNINMDPKDIAHIRAIVYSMTNAEKADPDLLNPSRRRR
IAAGSGRPIHEVNRMIKQFNQTKKMMNQMSKGNFAGMEGLMGGANGGGGIGGKMQQMAMKRMVRQTKKKKQKRLAKAMRR
RKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=488, Percent_Identity=31.7622950819672, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=32.9048843187661, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=38.3561643835616, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI23308697, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI295424842, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=47.877358490566, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1789874, Length=239, Percent_Identity=38.9121338912134, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=453, Percent_Identity=29.1390728476821, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=287, Percent_Identity=31.7073170731707, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=417, Percent_Identity=32.8537170263789, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6320498, Length=306, Percent_Identity=27.1241830065359, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=31.1111111111111, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24641198, Length=293, Percent_Identity=28.3276450511945, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 53903; Mature: 53772

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLTERLQKAMTNLRRKGKISESDLRATMREIRLALLEADVNFTVVKDFVKTVRERA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGAKVLEGLNPAQQIVKIVDEELTKTMGEKAVPLNKSPKIPTVIMMAGLQGAGKTTTVGK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
LALKLKNEQDARPLMIAADVYRPAAIEQLQQVGRQIDVPVFQLGTDVDPVEIVRQGMAQA
HHHEECCCCCCCCEEEEHHHCCHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHH
KENHNDYVFIDTAGRLQIDEQLMNELANIKDLVHPDEILLVIDAMTGQNAVNTAEGFNDK
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCC
LDVTGVVLTKLDGDTRGGAALSIRAVTGKPIKFVGQGEKMTDLDVFHPDRMADRILGMGD
CCEEEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCHH
MLTLIEKAQQQYDEKQAEEMNLKIQENTFDFNDFIDQLDQVDKMGNMEDIMKMIPGMANN
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PAMKNINMDPKDIAHIRAIVYSMTNAEKADPDLLNPSRRRRIAAGSGRPIHEVNRMIKQF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHH
NQTKKMMNQMSKGNFAGMEGLMGGANGGGGIGGKMQQMAMKRMVRQTKKKKQKRLAKAMR
HHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRKR
HHCC
>Mature Secondary Structure 
AFEGLTERLQKAMTNLRRKGKISESDLRATMREIRLALLEADVNFTVVKDFVKTVRERA
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGAKVLEGLNPAQQIVKIVDEELTKTMGEKAVPLNKSPKIPTVIMMAGLQGAGKTTTVGK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
LALKLKNEQDARPLMIAADVYRPAAIEQLQQVGRQIDVPVFQLGTDVDPVEIVRQGMAQA
HHHEECCCCCCCCEEEEHHHCCHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHH
KENHNDYVFIDTAGRLQIDEQLMNELANIKDLVHPDEILLVIDAMTGQNAVNTAEGFNDK
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCC
LDVTGVVLTKLDGDTRGGAALSIRAVTGKPIKFVGQGEKMTDLDVFHPDRMADRILGMGD
CCEEEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCHH
MLTLIEKAQQQYDEKQAEEMNLKIQENTFDFNDFIDQLDQVDKMGNMEDIMKMIPGMANN
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PAMKNINMDPKDIAHIRAIVYSMTNAEKADPDLLNPSRRRRIAAGSGRPIHEVNRMIKQF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHH
NQTKKMMNQMSKGNFAGMEGLMGGANGGGGIGGKMQQMAMKRMVRQTKKKKQKRLAKAMR
HHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRKR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]