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The map label for this gene is xseA

Identifier: 28378301

GI number: 28378301

Start: 1455431

End: 1456774

Strand: Direct

Name: xseA

Synonym: lp_1600

Alternate gene names: 28378301

Gene position: 1455431-1456774 (Clockwise)

Preceding gene: 28378300

Following gene: 28378302

Centisome position: 43.99

GC content: 47.1

Gene sequence:

>1344_bases
GTGAGTGAAAGTCAACAATATTTGACAGTGACAGCTTTAACTCAGTATTTAAAACGTAAATTCGAGGTTGATCCGTATTT
AGGTAAAGTGTACCTAACGGGGGAAGTTTCTAATTATCGTCCCCGGCCTAATACGCATCAATATTTCAGTTTGAAAGATG
ACCATGCCAAGATTTCAGCCATTATGTTCAAGTCGGCGTTTGCCAAGGTCAAATTTCAGCCTGAAGAAGGTATGAAGGTT
CTGGTCGTGGGCCGGATTGGTCTGTATGAGCCCAGTGGTAGTTACCAGATTTATGTGGAACGCATGGAACCAGACGGCGT
GGGTGCGTTGTATCAAGCCTACGAACAACTTAAAAAGAAATTAGCGGCTGAGGGCTTGTTTAGTGCACCCAAAAAGCCGC
TTCCGCGCTTTCCAAAGCGAATTGCAGTGGTCACTAGTCGTAGTGGCGCAGTGATTCGCGATATTATCACGACTACTCGG
CGCCGTTTTCCGATTGCGCAGATCGTTTTGTTTCCATCTCAAGTTCAAGGTGATGCGGCTGCGGCCGAAATTAGTCGGCA
GATCGAACGTGCCAATGCGCAAGGTGATTTTGATACATTAATTATTGGGCGTGGTGGTGGTTCAATCGAAGATCTGTGGC
CATTCAACGAAGAAGTGGTTGCGCGTGCAATCGCACAGAGTCAACTGCCAGTTATTTCATCCGTGGGGCATGAAACGGAT
ACGACAATTGCTGACTTGGTCGCAGATGTGCGGGCGGCCACCCCAACTGCGGCTGCCGAATTAGCGGTACCAGTATATAA
CGATGTTTTATTACAATTAAAGCAAGACCAGACCCGCGTGTTCAATGCATTTCAGAATTTCGTTCAACGCGATCGACAAC
GACTTAATAAATTACAAACGTCGTACGTGTTTACTCAGCCGAACCGCTTGTACGAAGGGTATTTGCAGAAGTTAGACTTC
TTAAATGAGCGACTTAAACAGGCTGGTCAAAATAACTTTAATCTGGCAAGCCAGCACTACCAGCGTGTTTTTCAACAATT
ACGACAGCAAACGCCGATTCACCAAGTTCGCCAGGCACAAACGCAACTGCTTAACTTGCAGCAACGGCTGAATCGGGGTA
CCCAGTTAGTCGTGCGGCAAAAACGGCAACAACTGACGCAGACCGTCCAATCGTTGGATCTACTTAGTCCGCTTAAAATC
ATGACGCGTGGTTACGCCTTTGTGACGGCGGATGAACAGGTGGTTCACGGGGTCAAACAATTGCAGCCAGAACAAACGGT
TGCAATTCACATGGCTGATGGTGAGGCTCAGGCACAGATTACGAAGATTGATGGAGGAAAATAA

Upstream 100 bases:

>100_bases
ATCGCAGGGTTGATTACGCCCGTTCCTGGTGGTGTGGGTCCAATGACGATTGCCACCTTGATGCAGACAACGGTGGAACT
TGCAAAGTGGAGTGATGTAA

Downstream 100 bases:

>100_bases
TGGCTGAACAACCAACTTTTGAACAGAATTTATCACAATTAGAGACGATCGTAAACCAATTAGAGCAGGGTGATGTTCCT
TTAGAACAAGCCTTGGATCA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSESQQYLTVTALTQYLKRKFEVDPYLGKVYLTGEVSNYRPRPNTHQYFSLKDDHAKISAIMFKSAFAKVKFQPEEGMKV
LVVGRIGLYEPSGSYQIYVERMEPDGVGALYQAYEQLKKKLAAEGLFSAPKKPLPRFPKRIAVVTSRSGAVIRDIITTTR
RRFPIAQIVLFPSQVQGDAAAAEISRQIERANAQGDFDTLIIGRGGGSIEDLWPFNEEVVARAIAQSQLPVISSVGHETD
TTIADLVADVRAATPTAAAELAVPVYNDVLLQLKQDQTRVFNAFQNFVQRDRQRLNKLQTSYVFTQPNRLYEGYLQKLDF
LNERLKQAGQNNFNLASQHYQRVFQQLRQQTPIHQVRQAQTQLLNLQQRLNRGTQLVVRQKRQQLTQTVQSLDLLSPLKI
MTRGYAFVTADEQVVHGVKQLQPEQTVAIHMADGEAQAQITKIDGGK

Sequences:

>Translated_447_residues
MSESQQYLTVTALTQYLKRKFEVDPYLGKVYLTGEVSNYRPRPNTHQYFSLKDDHAKISAIMFKSAFAKVKFQPEEGMKV
LVVGRIGLYEPSGSYQIYVERMEPDGVGALYQAYEQLKKKLAAEGLFSAPKKPLPRFPKRIAVVTSRSGAVIRDIITTTR
RRFPIAQIVLFPSQVQGDAAAAEISRQIERANAQGDFDTLIIGRGGGSIEDLWPFNEEVVARAIAQSQLPVISSVGHETD
TTIADLVADVRAATPTAAAELAVPVYNDVLLQLKQDQTRVFNAFQNFVQRDRQRLNKLQTSYVFTQPNRLYEGYLQKLDF
LNERLKQAGQNNFNLASQHYQRVFQQLRQQTPIHQVRQAQTQLLNLQQRLNRGTQLVVRQKRQQLTQTVQSLDLLSPLKI
MTRGYAFVTADEQVVHGVKQLQPEQTVAIHMADGEAQAQITKIDGGK
>Mature_446_residues
SESQQYLTVTALTQYLKRKFEVDPYLGKVYLTGEVSNYRPRPNTHQYFSLKDDHAKISAIMFKSAFAKVKFQPEEGMKVL
VVGRIGLYEPSGSYQIYVERMEPDGVGALYQAYEQLKKKLAAEGLFSAPKKPLPRFPKRIAVVTSRSGAVIRDIITTTRR
RFPIAQIVLFPSQVQGDAAAAEISRQIERANAQGDFDTLIIGRGGGSIEDLWPFNEEVVARAIAQSQLPVISSVGHETDT
TIADLVADVRAATPTAAAELAVPVYNDVLLQLKQDQTRVFNAFQNFVQRDRQRLNKLQTSYVFTQPNRLYEGYLQKLDFL
NERLKQAGQNNFNLASQHYQRVFQQLRQQTPIHQVRQAQTQLLNLQQRLNRGTQLVVRQKRQQLTQTVQSLDLLSPLKIM
TRGYAFVTADEQVVHGVKQLQPEQTVAIHMADGEAQAQITKIDGGK

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=444, Percent_Identity=39.6396396396396, Blast_Score=306, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_LACPL (Q88WM7)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785193.1
- GeneID:   1063609
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1600
- NMPDR:   fig|220668.1.peg.1327
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   LPLA220668:LP_1600-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50494; Mature: 50363

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESQQYLTVTALTQYLKRKFEVDPYLGKVYLTGEVSNYRPRPNTHQYFSLKDDHAKISA
CCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCEEEECCCHHHHHH
IMFKSAFAKVKFQPEEGMKVLVVGRIGLYEPSGSYQIYVERMEPDGVGALYQAYEQLKKK
HHHHHHHHHEEECCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHH
LAAEGLFSAPKKPLPRFPKRIAVVTSRSGAVIRDIITTTRRRFPIAQIVLFPSQVQGDAA
HHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCHHCCHHH
AAEISRQIERANAQGDFDTLIIGRGGGSIEDLWPFNEEVVARAIAQSQLPVISSVGHETD
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCC
TTIADLVADVRAATPTAAAELAVPVYNDVLLQLKQDQTRVFNAFQNFVQRDRQRLNKLQT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYVFTQPNRLYEGYLQKLDFLNERLKQAGQNNFNLASQHYQRVFQQLRQQTPIHQVRQAQ
HEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
TQLLNLQQRLNRGTQLVVRQKRQQLTQTVQSLDLLSPLKIMTRGYAFVTADEQVVHGVKQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
LQPEQTVAIHMADGEAQAQITKIDGGK
CCCCCEEEEEEECCCCCEEEEECCCCC
>Mature Secondary Structure 
SESQQYLTVTALTQYLKRKFEVDPYLGKVYLTGEVSNYRPRPNTHQYFSLKDDHAKISA
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCEEEECCCHHHHHH
IMFKSAFAKVKFQPEEGMKVLVVGRIGLYEPSGSYQIYVERMEPDGVGALYQAYEQLKKK
HHHHHHHHHEEECCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHH
LAAEGLFSAPKKPLPRFPKRIAVVTSRSGAVIRDIITTTRRRFPIAQIVLFPSQVQGDAA
HHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCHHCCHHH
AAEISRQIERANAQGDFDTLIIGRGGGSIEDLWPFNEEVVARAIAQSQLPVISSVGHETD
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCC
TTIADLVADVRAATPTAAAELAVPVYNDVLLQLKQDQTRVFNAFQNFVQRDRQRLNKLQT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYVFTQPNRLYEGYLQKLDFLNERLKQAGQNNFNLASQHYQRVFQQLRQQTPIHQVRQAQ
HEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
TQLLNLQQRLNRGTQLVVRQKRQQLTQTVQSLDLLSPLKIMTRGYAFVTADEQVVHGVKQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
LQPEQTVAIHMADGEAQAQITKIDGGK
CCCCCEEEEEEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566