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The map label for this gene is fthC [H]

Identifier: 28378275

GI number: 28378275

Start: 1437011

End: 1437577

Strand: Direct

Name: fthC [H]

Synonym: lp_1570

Alternate gene names: 28378275

Gene position: 1437011-1437577 (Clockwise)

Preceding gene: 28378274

Following gene: 28378276

Centisome position: 43.44

GC content: 49.56

Gene sequence:

>567_bases
GTGGAGAAAAAAGCATTTCGTAAGCAACAGCTTGGGCGATTAAGCCAAATGACGCCGGCTGACCGGCAACGGCAAAACCA
GGCGTTACAGACTCAATTATTTGCAAGCCCAACATGGCAAACTGCCCAGGTCATTGCCATGACAATTAGTAGTGACATCG
AAGTAGCGACGCGCCCACTTATTGAACAAGCTTGGGCGGAGGGCAAAATGGTGGTTATTCCAAAAACGCTGCCGCATCGT
CAAATGGCTTTTTATCCTTACCAAGCGACTGATCGACTTGAGCGAACGTCTTTTGGAATCCCAGAGCCCGTCACGGGTGA
ACCAGTCGCCAAGCAACAGATCGATCTGATCTTAGTTCCTGGTCTTGGGTACAGCCGTGACCGGCACGCCCGGATTGGAT
TTGGTGGTGGCTACTACGATCGTTACCTCGCTGATTATCCGGGTAAGAAGTTGACACTGGCTTATGACGAGATGGCTTTT
GAACACGCTGAATGGCCGGTTGATCAATATGACGTCTTGTTAGACGAACTCTTGGTAGCAGGGGATGAACAACATGATGA
GAATTAA

Upstream 100 bases:

>100_bases
GGGTTTCTCATTTGTTGGCAACTGCCAAATTGATTTTTCAATTTGACATGTTAATGAATGAGATTTTTTTATACCAATTT
TATTTTCGGGGGTGCCGTAC

Downstream 100 bases:

>100_bases
ACGCTGGTGGCAAACTGAACCGGCTATCACGCAGGTGCTACTTGGAATTACTGTGGCAGTCTTCTTAGTCGAGTGGCTGA
TGGGCGACGGCGCCATGCTG

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MEKKAFRKQQLGRLSQMTPADRQRQNQALQTQLFASPTWQTAQVIAMTISSDIEVATRPLIEQAWAEGKMVVIPKTLPHR
QMAFYPYQATDRLERTSFGIPEPVTGEPVAKQQIDLILVPGLGYSRDRHARIGFGGGYYDRYLADYPGKKLTLAYDEMAF
EHAEWPVDQYDVLLDELLVAGDEQHDEN

Sequences:

>Translated_188_residues
MEKKAFRKQQLGRLSQMTPADRQRQNQALQTQLFASPTWQTAQVIAMTISSDIEVATRPLIEQAWAEGKMVVIPKTLPHR
QMAFYPYQATDRLERTSFGIPEPVTGEPVAKQQIDLILVPGLGYSRDRHARIGFGGGYYDRYLADYPGKKLTLAYDEMAF
EHAEWPVDQYDVLLDELLVAGDEQHDEN
>Mature_188_residues
MEKKAFRKQQLGRLSQMTPADRQRQNQALQTQLFASPTWQTAQVIAMTISSDIEVATRPLIEQAWAEGKMVVIPKTLPHR
QMAFYPYQATDRLERTSFGIPEPVTGEPVAKQQIDLILVPGLGYSRDRHARIGFGGGYYDRYLADYPGKKLTLAYDEMAF
EHAEWPVDQYDVLLDELLVAGDEQHDEN

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=191, Percent_Identity=29.8429319371728, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1789278, Length=169, Percent_Identity=28.9940828402367, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510857, Length=199, Percent_Identity=32.1608040201005, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI161077430, Length=191, Percent_Identity=28.2722513089005, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 21443; Mature: 21443

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKAFRKQQLGRLSQMTPADRQRQNQALQTQLFASPTWQTAQVIAMTISSDIEVATRPL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHH
IEQAWAEGKMVVIPKTLPHRQMAFYPYQATDRLERTSFGIPEPVTGEPVAKQQIDLILVP
HHHHHCCCCEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEC
GLGYSRDRHARIGFGGGYYDRYLADYPGKKLTLAYDEMAFEHAEWPVDQYDVLLDELLVA
CCCCCCCCCEEEECCCCHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHC
GDEQHDEN
CCCCCCCC
>Mature Secondary Structure
MEKKAFRKQQLGRLSQMTPADRQRQNQALQTQLFASPTWQTAQVIAMTISSDIEVATRPL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHH
IEQAWAEGKMVVIPKTLPHRQMAFYPYQATDRLERTSFGIPEPVTGEPVAKQQIDLILVP
HHHHHCCCCEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEC
GLGYSRDRHARIGFGGGYYDRYLADYPGKKLTLAYDEMAFEHAEWPVDQYDVLLDELLVA
CCCCCCCCCEEEECCCCHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHC
GDEQHDEN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]