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The map label for this gene is gluP [H]

Identifier: 28378276

GI number: 28378276

Start: 1437564

End: 1438247

Strand: Direct

Name: gluP [H]

Synonym: lp_1571

Alternate gene names: 28378276

Gene position: 1437564-1438247 (Clockwise)

Preceding gene: 28378275

Following gene: 28378277

Centisome position: 43.45

GC content: 44.15

Gene sequence:

>684_bases
ATGATGAGAATTAAACGCTGGTGGCAAACTGAACCGGCTATCACGCAGGTGCTACTTGGAATTACTGTGGCAGTCTTCTT
AGTCGAGTGGCTGATGGGCGACGGCGCCATGCTGGTTTTTAATTCACTAGGTGCTAAGAACAATCAAGCAATTGCGGCCG
GCCAGTGGTGGCGATTGGTGACGCCGATGTTTTTACATATGGGACTTACCCATATTGCACTGAATGGTGTCGTTATTTAT
TTTATGGGCATGCAAATTGAAGCAATGTATGGTCATTGGCGGATGCTGGCAATTTATATTTTGGGTGGCATTAGTGGTAA
CATTATGAGTTTCGCGTTATCCAATAATCAGTCAGTAGGGGCCAGTACGGCGTGTTTCGCACTCTTTGGTGCCTTTTTGA
CGATTGGGGAATCGTTCTGGGAAAATCCAGTGATTCGCCAGCTCACGAACCAATTTTTACTACTAACCGTTTTGAATTTA
GTATTCGATATGTTCTCGAATGGCATTGATATCTGGGGACATGTCGGGGGTCTAGTTGGTGGCTTTTTGTTAGGCTATCT
GCTGGGTGTACCACGAATTGGCAAGATTGCGCCGCTGAAACGAATTGTGGCAACGGTTATTCTAGTCATTGGCTGGTTAG
CTTTATTAAAAATGGGTTTTACAAATGCTAATTTAACTGTATAA

Upstream 100 bases:

>100_bases
ACACTGGCTTATGACGAGATGGCTTTTGAACACGCTGAATGGCCGGTTGATCAATATGACGTCTTGTTAGACGAACTCTT
GGTAGCAGGGGATGAACAAC

Downstream 100 bases:

>100_bases
TTAATCGAGGATATGCACATGAAAACACTTTACGACGTCCAACAATTACTTAAAAAATTTGGCGTGTACGTGTACGTAGG
CAAGCGAATTTGGGATATTG

Product: integral membrane protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MMRIKRWWQTEPAITQVLLGITVAVFLVEWLMGDGAMLVFNSLGAKNNQAIAAGQWWRLVTPMFLHMGLTHIALNGVVIY
FMGMQIEAMYGHWRMLAIYILGGISGNIMSFALSNNQSVGASTACFALFGAFLTIGESFWENPVIRQLTNQFLLLTVLNL
VFDMFSNGIDIWGHVGGLVGGFLLGYLLGVPRIGKIAPLKRIVATVILVIGWLALLKMGFTNANLTV

Sequences:

>Translated_227_residues
MMRIKRWWQTEPAITQVLLGITVAVFLVEWLMGDGAMLVFNSLGAKNNQAIAAGQWWRLVTPMFLHMGLTHIALNGVVIY
FMGMQIEAMYGHWRMLAIYILGGISGNIMSFALSNNQSVGASTACFALFGAFLTIGESFWENPVIRQLTNQFLLLTVLNL
VFDMFSNGIDIWGHVGGLVGGFLLGYLLGVPRIGKIAPLKRIVATVILVIGWLALLKMGFTNANLTV
>Mature_227_residues
MMRIKRWWQTEPAITQVLLGITVAVFLVEWLMGDGAMLVFNSLGAKNNQAIAAGQWWRLVTPMFLHMGLTHIALNGVVIY
FMGMQIEAMYGHWRMLAIYILGGISGNIMSFALSNNQSVGASTACFALFGAFLTIGESFWENPVIRQLTNQFLLLTVLNL
VFDMFSNGIDIWGHVGGLVGGFLLGYLLGVPRIGKIAPLKRIVATVILVIGWLALLKMGFTNANLTV

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 24995; Mature: 24995

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRIKRWWQTEPAITQVLLGITVAVFLVEWLMGDGAMLVFNSLGAKNNQAIAAGQWWRLV
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCCCCEEECCHHHHHH
TPMFLHMGLTHIALNGVVIYFMGMQIEAMYGHWRMLAIYILGGISGNIMSFALSNNQSVG
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCC
ASTACFALFGAFLTIGESFWENPVIRQLTNQFLLLTVLNLVFDMFSNGIDIWGHVGGLVG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GFLLGYLLGVPRIGKIAPLKRIVATVILVIGWLALLKMGFTNANLTV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMRIKRWWQTEPAITQVLLGITVAVFLVEWLMGDGAMLVFNSLGAKNNQAIAAGQWWRLV
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCCCCEEECCHHHHHH
TPMFLHMGLTHIALNGVVIYFMGMQIEAMYGHWRMLAIYILGGISGNIMSFALSNNQSVG
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCC
ASTACFALFGAFLTIGESFWENPVIRQLTNQFLLLTVLNLVFDMFSNGIDIWGHVGGLVG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GFLLGYLLGVPRIGKIAPLKRIVATVILVIGWLALLKMGFTNANLTV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]