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The map label for this gene is pbp2B1 [H]

Identifier: 28378274

GI number: 28378274

Start: 1434552

End: 1436588

Strand: Direct

Name: pbp2B1 [H]

Synonym: lp_1568

Alternate gene names: 28378274

Gene position: 1434552-1436588 (Clockwise)

Preceding gene: 28378272

Following gene: 28378275

Centisome position: 43.36

GC content: 46.15

Gene sequence:

>2037_bases
TTGAAATTGTTTAAGAAAATTACGATAAATCGTGATCCCAACAAGTCGCATATTCCATTTCGGCTGAACTTCTTGTTTTT
CATCGTCTTCTTGTTATTTGCTGCGTTGATTGCGCAGTTAGCTTACTTACAAGTTGACTACGGACAGAAGTTCCGAAGTA
CAGTGAATTCAGCCAATAATACGACGGCAACGGGAAACGTTCAACGGGGATCGATTTATGATTCAACCGGTCGGGTCTTA
GTGGGAAACAAATCCCACCAAGCGATTCAATACACGAAGGGGCTGTCAGTTGCGTCGACTAAGATGTACGAAGTGGCGAA
TAAGTTAGGTGAGTACTTAACCATTCCAACGGATACATTAACGGATCGGAACTTGGCTGATTATTACTTAGCGGGGGCGG
CTAATTTAAAGTCGGTTGCTAAGAAGGTTAAAACGTCTAGCGACGATGATGTTTTGTACGCACGGGAAGTCGCCTATGCG
GAAAAACATATCATTAATAATTTAACGTCTACGCAAAAGAATGCGGCGGCGATTTATTATAAGATGAGTTCGGCGTACTC
GCTGTCAACGGTCAATATCAAATCGACTGGTGTGACGAGTACGGAGCTTGCTGAAATCGGTGAGCACCAATCCGAAATGC
CAGGAGTTAAGGTCGGAACGAGTTGGACTCGGAGTTATCCTAATGGGACTGACTTGAGTAGTGTGCTCGGGACAGTTACG
ACCGAAAAGCAAGGGCTACCGAGTGATAGCATTAAAACCTTGCTGGCAGAAGGCTATTCTCGTGATGATTCGGTTGGTCA
GAGCCAATTGGAAAAGCAGTACGAAAATGTCCTTCGTGGAACCAAGTCACAGACTGAGGTCAAGACGCAGGATGGGGTCA
TTCAAAAGGAGATTAAGAAGTACGGTGGCCAGAAGGGTGACAACGTTCAGCTGACGATTAATTCGAAGTTCCAGAAAAAG
GTTCAAAGTATCATTATGTCTGAAGCCAAAACGGTGGGGAGTAGCAATGCCTACTCGCCAGGAGCCTATGCTGTTGTAAT
GAACCCTAGCACTGGTGCCATTTATGCGTTAGCAGGTGCCAGCCGGAATCTATCCACTGGTAAAGTGACTGAAAATGCGT
TGGGAACCATCAACCAATCCTTCGTTATGGGGTCGGTCGTTAAGGGTGCTACGGTCATGGGTGCCTTGCAAGATGGTGTG
ATTACACCCACGAATAGTACTTTGACCGATACGCCGATCAAGTTAGCCGGAACGGCCACCAAGTCGTCATGGTTTAACAA
GAATGGTGGAACTAGTCTGAGTCTTAACGCTTCGACTGCCATGGAAGTTTCTTCTAACTCCTATATGATGCAATTAGCCA
TGAAGGAAGGTAACTTCAGCTATGCGTCTGGGAAAGCCTTGACGATGTCTAATTCGGTCTTCTCTAAACTTCGTGGTTAT
TTTAACGAGTTTGGCTTAGGTGTTAAGACCGGGATCGACTTGCCGGGTGAAGCCTCAGGTTACCAAGGTTCTTCGGCACA
GAAGGATATTGGTAAAGCGTTAGACTTGTCCTACGGGAACTACGATGCTTACACGACTATTCAGCTGGCGCAATACATTG
CGACAATGGCAAATGGTGGGCAACGCATTGCACCACACATCGTTTCCGCTATTACTGGGACTAAATCTAACGGGTCCCAA
GGGGCTGTTAAGACTAATGTTAAGCCACGTGTCCTGAATACCATTGACGTCCCATCCTCATACTTTGATGTCGTACACCA
AGGGTATTGGGATGTGGTCCATGGGAGTATGACGCAGCGGACGGGGAGTGCACTAGCTAGTTTATCACCAGCGGTTGCAG
CTAAGTCCGGGACTGCCGAGACATTCCACGGAACGACATCTACTGAAACGTTAAGTTTGGTGACTTATGCGCCTTATAAG
AACCCTAAAGTAGTGATAGCGGTTGCCTTTCCAGGAATTACTGCTACTAGTGGTGATTATAATATGGTCGTTGCTAAGCA
AATTTATGCAGCGTTCTGGAAGTATTATAACAAGTAA

Upstream 100 bases:

>100_bases
TTTAGAATAACATAAGTATGGTATTTATCTAGGATTGCTAGTATCATCTGGTAAATTTTTGCGAAATGTTTACCAAATTA
AGAATGGGAGCGCCTGAGAA

Downstream 100 bases:

>100_bases
AAAATCAGCTTTTTTCGTGCCAGTATCTTAATTGATACTGGTATTTTTTAATCATTAATGGTATAGTAGTTCAAGTTAAG
GGTTCCGGCCCTGTAATATG

Product: penicillin binding protein 2B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MKLFKKITINRDPNKSHIPFRLNFLFFIVFLLFAALIAQLAYLQVDYGQKFRSTVNSANNTTATGNVQRGSIYDSTGRVL
VGNKSHQAIQYTKGLSVASTKMYEVANKLGEYLTIPTDTLTDRNLADYYLAGAANLKSVAKKVKTSSDDDVLYAREVAYA
EKHIINNLTSTQKNAAAIYYKMSSAYSLSTVNIKSTGVTSTELAEIGEHQSEMPGVKVGTSWTRSYPNGTDLSSVLGTVT
TEKQGLPSDSIKTLLAEGYSRDDSVGQSQLEKQYENVLRGTKSQTEVKTQDGVIQKEIKKYGGQKGDNVQLTINSKFQKK
VQSIIMSEAKTVGSSNAYSPGAYAVVMNPSTGAIYALAGASRNLSTGKVTENALGTINQSFVMGSVVKGATVMGALQDGV
ITPTNSTLTDTPIKLAGTATKSSWFNKNGGTSLSLNASTAMEVSSNSYMMQLAMKEGNFSYASGKALTMSNSVFSKLRGY
FNEFGLGVKTGIDLPGEASGYQGSSAQKDIGKALDLSYGNYDAYTTIQLAQYIATMANGGQRIAPHIVSAITGTKSNGSQ
GAVKTNVKPRVLNTIDVPSSYFDVVHQGYWDVVHGSMTQRTGSALASLSPAVAAKSGTAETFHGTTSTETLSLVTYAPYK
NPKVVIAVAFPGITATSGDYNMVVAKQIYAAFWKYYNK

Sequences:

>Translated_678_residues
MKLFKKITINRDPNKSHIPFRLNFLFFIVFLLFAALIAQLAYLQVDYGQKFRSTVNSANNTTATGNVQRGSIYDSTGRVL
VGNKSHQAIQYTKGLSVASTKMYEVANKLGEYLTIPTDTLTDRNLADYYLAGAANLKSVAKKVKTSSDDDVLYAREVAYA
EKHIINNLTSTQKNAAAIYYKMSSAYSLSTVNIKSTGVTSTELAEIGEHQSEMPGVKVGTSWTRSYPNGTDLSSVLGTVT
TEKQGLPSDSIKTLLAEGYSRDDSVGQSQLEKQYENVLRGTKSQTEVKTQDGVIQKEIKKYGGQKGDNVQLTINSKFQKK
VQSIIMSEAKTVGSSNAYSPGAYAVVMNPSTGAIYALAGASRNLSTGKVTENALGTINQSFVMGSVVKGATVMGALQDGV
ITPTNSTLTDTPIKLAGTATKSSWFNKNGGTSLSLNASTAMEVSSNSYMMQLAMKEGNFSYASGKALTMSNSVFSKLRGY
FNEFGLGVKTGIDLPGEASGYQGSSAQKDIGKALDLSYGNYDAYTTIQLAQYIATMANGGQRIAPHIVSAITGTKSNGSQ
GAVKTNVKPRVLNTIDVPSSYFDVVHQGYWDVVHGSMTQRTGSALASLSPAVAAKSGTAETFHGTTSTETLSLVTYAPYK
NPKVVIAVAFPGITATSGDYNMVVAKQIYAAFWKYYNK
>Mature_678_residues
MKLFKKITINRDPNKSHIPFRLNFLFFIVFLLFAALIAQLAYLQVDYGQKFRSTVNSANNTTATGNVQRGSIYDSTGRVL
VGNKSHQAIQYTKGLSVASTKMYEVANKLGEYLTIPTDTLTDRNLADYYLAGAANLKSVAKKVKTSSDDDVLYAREVAYA
EKHIINNLTSTQKNAAAIYYKMSSAYSLSTVNIKSTGVTSTELAEIGEHQSEMPGVKVGTSWTRSYPNGTDLSSVLGTVT
TEKQGLPSDSIKTLLAEGYSRDDSVGQSQLEKQYENVLRGTKSQTEVKTQDGVIQKEIKKYGGQKGDNVQLTINSKFQKK
VQSIIMSEAKTVGSSNAYSPGAYAVVMNPSTGAIYALAGASRNLSTGKVTENALGTINQSFVMGSVVKGATVMGALQDGV
ITPTNSTLTDTPIKLAGTATKSSWFNKNGGTSLSLNASTAMEVSSNSYMMQLAMKEGNFSYASGKALTMSNSVFSKLRGY
FNEFGLGVKTGIDLPGEASGYQGSSAQKDIGKALDLSYGNYDAYTTIQLAQYIATMANGGQRIAPHIVSAITGTKSNGSQ
GAVKTNVKPRVLNTIDVPSSYFDVVHQGYWDVVHGSMTQRTGSALASLSPAVAAKSGTAETFHGTTSTETLSLVTYAPYK
NPKVVIAVAFPGITATSGDYNMVVAKQIYAAFWKYYNK

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=524, Percent_Identity=24.8091603053435, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786272, Length=335, Percent_Identity=26.5671641791045, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 72672; Mature: 72672

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFKKITINRDPNKSHIPFRLNFLFFIVFLLFAALIAQLAYLQVDYGQKFRSTVNSANN
CCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
TTATGNVQRGSIYDSTGRVLVGNKSHQAIQYTKGLSVASTKMYEVANKLGEYLTIPTDTL
CCCCCCEECCCEECCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCC
TDRNLADYYLAGAANLKSVAKKVKTSSDDDVLYAREVAYAEKHIINNLTSTQKNAAAIYY
CCCCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEE
KMSSAYSLSTVNIKSTGVTSTELAEIGEHQSEMPGVKVGTSWTRSYPNGTDLSSVLGTVT
EECCCEEEEEEEEECCCCCHHHHHHHHCHHHHCCCEEECCCHHCCCCCCCCHHHHHHHHC
TEKQGLPSDSIKTLLAEGYSRDDSVGQSQLEKQYENVLRGTKSQTEVKTQDGVIQKEIKK
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHH
YGGQKGDNVQLTINSKFQKKVQSIIMSEAKTVGSSNAYSPGAYAVVMNPSTGAIYALAGA
HCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEECC
SRNLSTGKVTENALGTINQSFVMGSVVKGATVMGALQDGVITPTNSTLTDTPIKLAGTAT
CCCCCCCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHCCEECCCCCCCCCCCEEEEECCC
KSSWFNKNGGTSLSLNASTAMEVSSNSYMMQLAMKEGNFSYASGKALTMSNSVFSKLRGY
CCCCCCCCCCCEEEECCCEEEEECCCCEEEEEEEECCCCEECCCCEEEECHHHHHHHHHH
FNEFGLGVKTGIDLPGEASGYQGSSAQKDIGKALDLSYGNYDAYTTIQLAQYIATMANGG
HHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
QRIAPHIVSAITGTKSNGSQGAVKTNVKPRVLNTIDVPSSYFDVVHQGYWDVVHGSMTQR
CCHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEECCCHHHHHHHHCCCHHHHCCCHHHH
TGSALASLSPAVAAKSGTAETFHGTTSTETLSLVTYAPYKNPKVVIAVAFPGITATSGDY
HHHHHHHCCHHHHCCCCCCCEECCCCCCCEEEEEEECCCCCCCEEEEEEECCEEECCCCC
NMVVAKQIYAAFWKYYNK
EEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLFKKITINRDPNKSHIPFRLNFLFFIVFLLFAALIAQLAYLQVDYGQKFRSTVNSANN
CCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
TTATGNVQRGSIYDSTGRVLVGNKSHQAIQYTKGLSVASTKMYEVANKLGEYLTIPTDTL
CCCCCCEECCCEECCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCC
TDRNLADYYLAGAANLKSVAKKVKTSSDDDVLYAREVAYAEKHIINNLTSTQKNAAAIYY
CCCCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEE
KMSSAYSLSTVNIKSTGVTSTELAEIGEHQSEMPGVKVGTSWTRSYPNGTDLSSVLGTVT
EECCCEEEEEEEEECCCCCHHHHHHHHCHHHHCCCEEECCCHHCCCCCCCCHHHHHHHHC
TEKQGLPSDSIKTLLAEGYSRDDSVGQSQLEKQYENVLRGTKSQTEVKTQDGVIQKEIKK
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHH
YGGQKGDNVQLTINSKFQKKVQSIIMSEAKTVGSSNAYSPGAYAVVMNPSTGAIYALAGA
HCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEECC
SRNLSTGKVTENALGTINQSFVMGSVVKGATVMGALQDGVITPTNSTLTDTPIKLAGTAT
CCCCCCCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHCCEECCCCCCCCCCCEEEEECCC
KSSWFNKNGGTSLSLNASTAMEVSSNSYMMQLAMKEGNFSYASGKALTMSNSVFSKLRGY
CCCCCCCCCCCEEEECCCEEEEECCCCEEEEEEEECCCCEECCCCEEEECHHHHHHHHHH
FNEFGLGVKTGIDLPGEASGYQGSSAQKDIGKALDLSYGNYDAYTTIQLAQYIATMANGG
HHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
QRIAPHIVSAITGTKSNGSQGAVKTNVKPRVLNTIDVPSSYFDVVHQGYWDVVHGSMTQR
CCHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEECCCHHHHHHHHCCCHHHHCCCHHHH
TGSALASLSPAVAAKSGTAETFHGTTSTETLSLVTYAPYKNPKVVIAVAFPGITATSGDY
HHHHHHHCCHHHHCCCCCCCEECCCCCCCEEEEEEECCCCCCCEEEEEEECCEEECCCCC
NMVVAKQIYAAFWKYYNK
EEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 2654541 [H]