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The map label for this gene is menA [H]

Identifier: 28378256

GI number: 28378256

Start: 1413054

End: 1414022

Strand: Direct

Name: menA [H]

Synonym: lp_1546

Alternate gene names: 28378256

Gene position: 1413054-1414022 (Clockwise)

Preceding gene: 28378255

Following gene: 28378259

Centisome position: 42.71

GC content: 41.49

Gene sequence:

>969_bases
TTGTTGACGAACGAACCAACTTATCGGCCAATGACGTTCAAAATTTTTTTGGAATTCATTCGGCTAAATGCCAAGGCAGC
TAGTGTGGTGCCGTATTTTATTGGTATTTTATTTTCAATCTATTATTTTCATGCGTTTAATTGGATCAATTCGTTAATTT
ACTTAGTTGCACAAGTAGCGATTGCATTGTTTGTGACGGGGTTTAATAACGTGCAGGATTACTACTTGGCTAAGGATTTA
CATTATCGGGATACTTATAACATTGTTGGCCGTGAGCACCTATCACCACGACGATCATTGAATTTGATGCTAGCGATGTT
AGCAACTGCAATTATTTTAGGATTAGTGCTAGTCGTCAGAACAAACCTATTGTTACTGTTCATGGGCGCTGCAGCGATTG
GTGTGGCTATCTTCTATACCTATGGCCCGGTACCGTTTTCGCGCTTCCCGTTGGGTGAATTACTGTCGGGATGTGTCGAA
GGATTTGGCGTTTTCTTTCTGAGTGTTTATATGAACGTCGCGACCCCCGTACTGGCGGGCTTTAAGTTTGCTTGGCCGCA
GTTTGCGATTGTGGGGAATTTAGAGAACATATTGGTCATGATTTTGGTGGGGCTACCAGGGATTTTCTTGGTTGCGAATA
TCATGTTAGCTGATAATATTTCAGATTTACAACAGGATATTCGCAATGAACGTTATACGGTTCCGTACTATATTGGTCAT
CGTTGGTCACTACGGGTCTACGATACGCTGGCGCTGTTAGGTTATTTGCCAGTGCTGATGAGTGTTGTTTTACAAATACT
ACCGATTTATCAGCTGGCAGTGTTGCTCGTTTTACCAAAAATTTTGAAGAATATTCGGGCCTTTAACGCGGTGCAGGTGA
AAGAAACCACCTTTAATACGGCACCACAAAATTTGATGATGTTTCAAGGCATGCAATTACTTGGACTGATCCTGGGTATT
TTCTTTTAA

Upstream 100 bases:

>100_bases
AGCTGACCGATATTTGTTGGTATGTTCATCATGAAACCATTTTCACAAGTAACCTTTTTTGGTATAGTGGAAGAGTAGTT
AATTTAATCAGGGGGCGAAG

Downstream 100 bases:

>100_bases
TCCGGTCTGATTAATTGGGATGGTTCACAAAAACAGCGGCCGTCATCCAGCATAATTGCTGAATGACGGCCGCCGTTTTT
TGTGTCGCTGTTTTTTGGAC

Product: prenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MLTNEPTYRPMTFKIFLEFIRLNAKAASVVPYFIGILFSIYYFHAFNWINSLIYLVAQVAIALFVTGFNNVQDYYLAKDL
HYRDTYNIVGREHLSPRRSLNLMLAMLATAIILGLVLVVRTNLLLLFMGAAAIGVAIFYTYGPVPFSRFPLGELLSGCVE
GFGVFFLSVYMNVATPVLAGFKFAWPQFAIVGNLENILVMILVGLPGIFLVANIMLADNISDLQQDIRNERYTVPYYIGH
RWSLRVYDTLALLGYLPVLMSVVLQILPIYQLAVLLVLPKILKNIRAFNAVQVKETTFNTAPQNLMMFQGMQLLGLILGI
FF

Sequences:

>Translated_322_residues
MLTNEPTYRPMTFKIFLEFIRLNAKAASVVPYFIGILFSIYYFHAFNWINSLIYLVAQVAIALFVTGFNNVQDYYLAKDL
HYRDTYNIVGREHLSPRRSLNLMLAMLATAIILGLVLVVRTNLLLLFMGAAAIGVAIFYTYGPVPFSRFPLGELLSGCVE
GFGVFFLSVYMNVATPVLAGFKFAWPQFAIVGNLENILVMILVGLPGIFLVANIMLADNISDLQQDIRNERYTVPYYIGH
RWSLRVYDTLALLGYLPVLMSVVLQILPIYQLAVLLVLPKILKNIRAFNAVQVKETTFNTAPQNLMMFQGMQLLGLILGI
FF
>Mature_322_residues
MLTNEPTYRPMTFKIFLEFIRLNAKAASVVPYFIGILFSIYYFHAFNWINSLIYLVAQVAIALFVTGFNNVQDYYLAKDL
HYRDTYNIVGREHLSPRRSLNLMLAMLATAIILGLVLVVRTNLLLLFMGAAAIGVAIFYTYGPVPFSRFPLGELLSGCVE
GFGVFFLSVYMNVATPVLAGFKFAWPQFAIVGNLENILVMILVGLPGIFLVANIMLADNISDLQQDIRNERYTVPYYIGH
RWSLRVYDTLALLGYLPVLMSVVLQILPIYQLAVLLVLPKILKNIRAFNAVQVKETTFNTAPQNLMMFQGMQLLGLILGI
FF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 36383; Mature: 36383

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNEPTYRPMTFKIFLEFIRLNAKAASVVPYFIGILFSIYYFHAFNWINSLIYLVAQVA
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IALFVTGFNNVQDYYLAKDLHYRDTYNIVGREHLSPRRSLNLMLAMLATAIILGLVLVVR
HHHHHHCCCCHHHHHHHHHCCCCCHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
TNLLLLFMGAAAIGVAIFYTYGPVPFSRFPLGELLSGCVEGFGVFFLSVYMNVATPVLAG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FKFAWPQFAIVGNLENILVMILVGLPGIFLVANIMLADNISDLQQDIRNERYTVPYYIGH
CHHCCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECC
RWSLRVYDTLALLGYLPVLMSVVLQILPIYQLAVLLVLPKILKNIRAFNAVQVKETTFNT
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCC
APQNLMMFQGMQLLGLILGIFF
CHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLTNEPTYRPMTFKIFLEFIRLNAKAASVVPYFIGILFSIYYFHAFNWINSLIYLVAQVA
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IALFVTGFNNVQDYYLAKDLHYRDTYNIVGREHLSPRRSLNLMLAMLATAIILGLVLVVR
HHHHHHCCCCHHHHHHHHHCCCCCHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
TNLLLLFMGAAAIGVAIFYTYGPVPFSRFPLGELLSGCVEGFGVFFLSVYMNVATPVLAG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FKFAWPQFAIVGNLENILVMILVGLPGIFLVANIMLADNISDLQQDIRNERYTVPYYIGH
CHHCCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEECC
RWSLRVYDTLALLGYLPVLMSVVLQILPIYQLAVLLVLPKILKNIRAFNAVQVKETTFNT
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCC
APQNLMMFQGMQLLGLILGIFF
CHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]