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The map label for this gene is hpk5 [H]

Identifier: 28378255

GI number: 28378255

Start: 1411040

End: 1412683

Strand: Direct

Name: hpk5 [H]

Synonym: lp_1545

Alternate gene names: 28378255

Gene position: 1411040-1412683 (Clockwise)

Preceding gene: 28378254

Following gene: 28378256

Centisome position: 42.65

GC content: 45.8

Gene sequence:

>1644_bases
ATGACTGACGCTGATACGAATCAAGTGACGCCTAAACCACGGCGCCGTTGGTCATTAAAATGGAAATGGGCGCTCGGGAC
CGCAATTGGGTCCGCGCTCATTTTTATTTGTTTTTCATTATTGGTCTATAAGAGTTTCACGAACCTCTTATTGCGCCAAG
AACAACGGAACGTGGCTAGTGCTGTTACAACGGTGCAACAATCGTTGCGAACGGAGTCGAAAGGGCTGACCATTAAGTCG
GTGGCCGCTAAATTGCAACCCGAGGCGAGCGTTGAACCGGCAACTACCATGAGTGAACGTAAGCATGGTGTGCTGCAAAG
TAAAATCTTTTCAGATTCCGATTTAACAGCCTTATCCCGCACAAACTTAGCTGTGACGGTTTATGATCCACACGGGAACA
CACTCTATCTATCCCGCAAGGATGCACATGAGTTCTCTAAGAATAAGACGCGTCAGGTGGTGGTGATTGGCCGAGGAAGT
GATGCTGAATTAGTTGGGCGGGCGCCCATTTATGCGGCTAGCAATCACCGTTTGATCGGTTACACCCAGGTCACTGATAA
TTTGGCGGAATACCATTCAACGACTCAGAATTTGATCTGGATCTTTATTGTAATGACAATGATCACTATTTTTGGTGCCA
CGCTACTGGGCTACTTCTTAGCTGCGTTTCTATTACGGCCAATGCGTAAAATCAAACAGACGATTAATGCGGTCAATGAT
GATCCGCAAACTGACTCGCGAGTGCCCGATCTTAAACGCAATGATGAATTGTCGGATTTAGCAGTTGTATTCAATGATAT
GCTTGATCAGATGCAACGCTATATTAATCAACAGCAGCAATTTGTTGAAGACGTTTCCCATGAATTACGGACCCCGGTGG
CAATTATCCAGGGCCATATGGAGTTGCTGAATCGATGGGGCAAGGATGATCCACAAGTGTTGTCGGAATCATTGGCGGCT
AGTTTGTCAGAAACCAAGCGAATGCAGAGCTTAGTTCAAGAAATGTTGGACTTATCGCGTGCTGAACAATTGGAAATCAA
TTTTAGCCATGAGACGTCGGACGTTCAGAAGTTAGTGACGCAAGCATTTAACGATTTTACGATGATTCATCCCGACTTTC
ATTTTACGTTTGATGATGATGTTAAAAAGCCGGTGTATGCTCAGATTTACCGTAATCACCTCGAGCAAATTCTGATTATT
TTATTGGATAATGCGGTCAAGTACTCGACACGACGTAAAGAAATCCATTTATCATTATCCACGGATTATCGCTACATTGA
AGTCGCCGTCCAAGACTTTGGTGAGGGTATTTCTAAGGACAATCTCGATCGGGTTTTCAACCGTTTCTATCGGGTTGATA
AGGCGCGTAGCCGTGATAAGGGTGGTAACGGGTTAGGATTATCCATTGCGCAACGGTTAGTTGAAGGTTACCATGGTCAT
ATTAGTGTTGAATCTGTGGTGGGCCAAGGCTCGATCTTTCGGTTCCAGTTACCGATTCTACGGGACGCGAAGCTCTTAGC
TAAGGCCGAGGCTGAAACGAATGATGTTGAAAAGATTGCCAAGTCGGAACTGCCAGCCGGAATCCGACCAGCTACTCGTG
ATGAAGATGAAGCGCCCTTGGATGATCATGAGCACGACCACTAG

Upstream 100 bases:

>100_bases
TCGACGTTTATATCCGTTACTTACGGAACAAGATTGACCGACCAGGAGAAAAGAGTTACATCCAAACTGTTCGTGGGACT
GGATACGTGATTCGTTCTTA

Downstream 100 bases:

>100_bases
GTAATCGAATTATTGATGAATTTAAAACGCACATTCAAGTTAATTTAACTTGAATGTGCGTTTTCAGTTTGGATAATTGC
GCTGTAATGAATTTTAAAGC

Product: histidine protein kinase; sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTDADTNQVTPKPRRRWSLKWKWALGTAIGSALIFICFSLLVYKSFTNLLLRQEQRNVASAVTTVQQSLRTESKGLTIKS
VAAKLQPEASVEPATTMSERKHGVLQSKIFSDSDLTALSRTNLAVTVYDPHGNTLYLSRKDAHEFSKNKTRQVVVIGRGS
DAELVGRAPIYAASNHRLIGYTQVTDNLAEYHSTTQNLIWIFIVMTMITIFGATLLGYFLAAFLLRPMRKIKQTINAVND
DPQTDSRVPDLKRNDELSDLAVVFNDMLDQMQRYINQQQQFVEDVSHELRTPVAIIQGHMELLNRWGKDDPQVLSESLAA
SLSETKRMQSLVQEMLDLSRAEQLEINFSHETSDVQKLVTQAFNDFTMIHPDFHFTFDDDVKKPVYAQIYRNHLEQILII
LLDNAVKYSTRRKEIHLSLSTDYRYIEVAVQDFGEGISKDNLDRVFNRFYRVDKARSRDKGGNGLGLSIAQRLVEGYHGH
ISVESVVGQGSIFRFQLPILRDAKLLAKAEAETNDVEKIAKSELPAGIRPATRDEDEAPLDDHEHDH

Sequences:

>Translated_547_residues
MTDADTNQVTPKPRRRWSLKWKWALGTAIGSALIFICFSLLVYKSFTNLLLRQEQRNVASAVTTVQQSLRTESKGLTIKS
VAAKLQPEASVEPATTMSERKHGVLQSKIFSDSDLTALSRTNLAVTVYDPHGNTLYLSRKDAHEFSKNKTRQVVVIGRGS
DAELVGRAPIYAASNHRLIGYTQVTDNLAEYHSTTQNLIWIFIVMTMITIFGATLLGYFLAAFLLRPMRKIKQTINAVND
DPQTDSRVPDLKRNDELSDLAVVFNDMLDQMQRYINQQQQFVEDVSHELRTPVAIIQGHMELLNRWGKDDPQVLSESLAA
SLSETKRMQSLVQEMLDLSRAEQLEINFSHETSDVQKLVTQAFNDFTMIHPDFHFTFDDDVKKPVYAQIYRNHLEQILII
LLDNAVKYSTRRKEIHLSLSTDYRYIEVAVQDFGEGISKDNLDRVFNRFYRVDKARSRDKGGNGLGLSIAQRLVEGYHGH
ISVESVVGQGSIFRFQLPILRDAKLLAKAEAETNDVEKIAKSELPAGIRPATRDEDEAPLDDHEHDH
>Mature_546_residues
TDADTNQVTPKPRRRWSLKWKWALGTAIGSALIFICFSLLVYKSFTNLLLRQEQRNVASAVTTVQQSLRTESKGLTIKSV
AAKLQPEASVEPATTMSERKHGVLQSKIFSDSDLTALSRTNLAVTVYDPHGNTLYLSRKDAHEFSKNKTRQVVVIGRGSD
AELVGRAPIYAASNHRLIGYTQVTDNLAEYHSTTQNLIWIFIVMTMITIFGATLLGYFLAAFLLRPMRKIKQTINAVNDD
PQTDSRVPDLKRNDELSDLAVVFNDMLDQMQRYINQQQQFVEDVSHELRTPVAIIQGHMELLNRWGKDDPQVLSESLAAS
LSETKRMQSLVQEMLDLSRAEQLEINFSHETSDVQKLVTQAFNDFTMIHPDFHFTFDDDVKKPVYAQIYRNHLEQILIIL
LDNAVKYSTRRKEIHLSLSTDYRYIEVAVQDFGEGISKDNLDRVFNRFYRVDKARSRDKGGNGLGLSIAQRLVEGYHGHI
SVESVVGQGSIFRFQLPILRDAKLLAKAEAETNDVEKIAKSELPAGIRPATRDEDEAPLDDHEHDH

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=245, Percent_Identity=31.8367346938775, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=28.4584980237154, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=431, Percent_Identity=25.0580046403712, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=27.719298245614, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=29.5275590551181, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=26.25, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=27.3809523809524, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788279, Length=321, Percent_Identity=23.98753894081, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788549, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789149, Length=389, Percent_Identity=25.1928020565553, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=27.3972602739726, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790551, Length=301, Percent_Identity=26.2458471760797, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=317, Percent_Identity=23.3438485804416, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=28.0542986425339, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=26.6211604095563, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787374, Length=296, Percent_Identity=22.2972972972973, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=87, Percent_Identity=42.5287356321839, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62062; Mature: 61931

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDADTNQVTPKPRRRWSLKWKWALGTAIGSALIFICFSLLVYKSFTNLLLRQEQRNVAS
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTTVQQSLRTESKGLTIKSVAAKLQPEASVEPATTMSERKHGVLQSKIFSDSDLTALSR
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEC
TNLAVTVYDPHGNTLYLSRKDAHEFSKNKTRQVVVIGRGSDAELVGRAPIYAASNHRLIG
CCEEEEEECCCCCEEEEECCHHHHHHCCCCEEEEEEECCCCCCEECCCCEEECCCCEEEE
YTQVTDNLAEYHSTTQNLIWIFIVMTMITIFGATLLGYFLAAFLLRPMRKIKQTINAVND
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPQTDSRVPDLKRNDELSDLAVVFNDMLDQMQRYINQQQQFVEDVSHELRTPVAIIQGHM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ELLNRWGKDDPQVLSESLAASLSETKRMQSLVQEMLDLSRAEQLEINFSHETSDVQKLVT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
QAFNDFTMIHPDFHFTFDDDVKKPVYAQIYRNHLEQILIILLDNAVKYSTRRKEIHLSLS
HHHCCCEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
TDYRYIEVAVQDFGEGISKDNLDRVFNRFYRVDKARSRDKGGNGLGLSIAQRLVEGYHGH
CCCEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
ISVESVVGQGSIFRFQLPILRDAKLLAKAEAETNDVEKIAKSELPAGIRPATRDEDEAPL
EEHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DDHEHDH
CCCCCCC
>Mature Secondary Structure 
TDADTNQVTPKPRRRWSLKWKWALGTAIGSALIFICFSLLVYKSFTNLLLRQEQRNVAS
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTTVQQSLRTESKGLTIKSVAAKLQPEASVEPATTMSERKHGVLQSKIFSDSDLTALSR
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEC
TNLAVTVYDPHGNTLYLSRKDAHEFSKNKTRQVVVIGRGSDAELVGRAPIYAASNHRLIG
CCEEEEEECCCCCEEEEECCHHHHHHCCCCEEEEEEECCCCCCEECCCCEEECCCCEEEE
YTQVTDNLAEYHSTTQNLIWIFIVMTMITIFGATLLGYFLAAFLLRPMRKIKQTINAVND
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPQTDSRVPDLKRNDELSDLAVVFNDMLDQMQRYINQQQQFVEDVSHELRTPVAIIQGHM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ELLNRWGKDDPQVLSESLAASLSETKRMQSLVQEMLDLSRAEQLEINFSHETSDVQKLVT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
QAFNDFTMIHPDFHFTFDDDVKKPVYAQIYRNHLEQILIILLDNAVKYSTRRKEIHLSLS
HHHCCCEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
TDYRYIEVAVQDFGEGISKDNLDRVFNRFYRVDKARSRDKGGNGLGLSIAQRLVEGYHGH
CCCEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
ISVESVVGQGSIFRFQLPILRDAKLLAKAEAETNDVEKIAKSELPAGIRPATRDEDEAPL
EEHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DDHEHDH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA