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The map label for this gene is nrdR

Identifier: 28378225

GI number: 28378225

Start: 1382630

End: 1383145

Strand: Direct

Name: nrdR

Synonym: lp_1511

Alternate gene names: 28378225

Gene position: 1382630-1383145 (Clockwise)

Preceding gene: 28378224

Following gene: 28378226

Centisome position: 41.79

GC content: 46.9

Gene sequence:

>516_bases
ATGCAATGTCCACATTGTCATCATAATGGCTCCCGCGTGGTTGACAGTCGACCAACTGATGATGGTCGCGTGATTCGACG
GCGCCGGGAATGCGAAAACTGTGGGTTCCGGTTCACAACATTTGAACGGGTCGAAGCCACGCCATTATTAGTCATTAAGA
AAAATGGTGCCCGCGAAGAATTCAATCGTGAAAAAGTCTTGCGCGGAATTATTCGCTCGGCCGAGAAACGACCCGTTAGC
ATGGAAACCATGACGGGCGTCGTTGATGATGTTGAAAATAAGGTCCGGTCACTGGGCGAAAATGAAATTTCAAGCCAAGT
TATCGGCGAGTATGTCATGGAGCAATTGGCAGATATTGACGAAATTTCGTACATTCGTTTTGCCAGTGTTTACCGGCAAT
TCAAGGATATGCACGTCTTCTTGAATGAACTCCAAGATATGATGGAGCGTGATAAGGTCAAACTGGCAAAACCGTCAGCG
AAGACGACCCACGCACCTAAACGAAAAAAAGATTAG

Upstream 100 bases:

>100_bases
CCAACATTGATAAAACTAAAGCAGCCGTGTTAAAATGGCTGAAAACTATTACTAAATAAAGAAAAACTGATTGTTAGTTG
TTACAAGGGGTGAGAAGTCT

Downstream 100 bases:

>100_bases
TGAAAAAGAATGGTGAACAACATGCCAAATGATGAACCCTTAACACCCAAAACTGGGTTAGTGGTCCCGCAAGCACCAGC
GCTCAGTGCGGCGCAACAAG

Product: transcriptional regulator NrdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECENCGFRFTTFERVEATPLLVIKKNGAREEFNREKVLRGIIRSAEKRPVS
METMTGVVDDVENKVRSLGENEISSQVIGEYVMEQLADIDEISYIRFASVYRQFKDMHVFLNELQDMMERDKVKLAKPSA
KTTHAPKRKKD

Sequences:

>Translated_171_residues
MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECENCGFRFTTFERVEATPLLVIKKNGAREEFNREKVLRGIIRSAEKRPVS
METMTGVVDDVENKVRSLGENEISSQVIGEYVMEQLADIDEISYIRFASVYRQFKDMHVFLNELQDMMERDKVKLAKPSA
KTTHAPKRKKD
>Mature_171_residues
MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECENCGFRFTTFERVEATPLLVIKKNGAREEFNREKVLRGIIRSAEKRPVS
METMTGVVDDVENKVRSLGENEISSQVIGEYVMEQLADIDEISYIRFASVYRQFKDMHVFLNELQDMMERDKVKLAKPSA
KTTHAPKRKKD

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=144, Percent_Identity=45.1388888888889, Blast_Score=136, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_LACPL (Q88WV2)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785117.1
- GeneID:   1064152
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1511
- NMPDR:   fig|220668.1.peg.1251
- HOGENOM:   HBG351755
- OMA:   FASVYRD
- ProtClustDB:   PRK00464
- BioCyc:   LPLA220668:LP_1511-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 19886; Mature: 19886

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECENCGFRFTTFERVEATPLLVIKKNGAREE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHCCCEEEEEECCCCHHH
FNREKVLRGIIRSAEKRPVSMETMTGVVDDVENKVRSLGENEISSQVIGEYVMEQLADID
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHH
EISYIRFASVYRQFKDMHVFLNELQDMMERDKVKLAKPSAKTTHAPKRKKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECENCGFRFTTFERVEATPLLVIKKNGAREE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHCCCEEEEEECCCCHHH
FNREKVLRGIIRSAEKRPVSMETMTGVVDDVENKVRSLGENEISSQVIGEYVMEQLADID
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHH
EISYIRFASVYRQFKDMHVFLNELQDMMERDKVKLAKPSAKTTHAPKRKKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566