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The map label for this gene is hexR [H]

Identifier: 28377934

GI number: 28377934

Start: 1056331

End: 1057209

Strand: Direct

Name: hexR [H]

Synonym: lp_1157

Alternate gene names: 28377934

Gene position: 1056331-1057209 (Clockwise)

Preceding gene: 28377933

Following gene: 28377935

Centisome position: 31.93

GC content: 47.33

Gene sequence:

>879_bases
ATGTCCACACAATCACCAGTACATCGCAATCGGGTCCTGACTTTAATTCGGTCTTATTATCCGAATTTAAGTGTGACGGA
CCGCAAGATTGCTGACTATATTATTGCCGACCCAATTAAAACGGCGGCTCAGTCGATTTCAGACTTGGCTGCCGCGGTTG
GCGTTTCAACGGCCACGGTTTCACGGTTTGTCAAACGGATTAGTTTTAGTAGCTTCCGTGACTTCTCACGTGAACTAACG
GCGGCCGAACCGATTGAACAAACTAATGCGGAAGCTTTTCAAGATGTCGAAAAACAAACGACTTTCAAAGGAATTGCGGA
ATCAACATTCAATAGTATTCGTAGTTCGCTAGATCAGACAAGTCAGGTAATGACGGAAGCAGATCTCAAGCGGGCGGTGG
AATTATTGCTAAATGCTCGCTCGATTGGCTTTTATGGCCTCGGGGGCTCCGCAGTTGCTGCCTTAGATGGGTATCATAAG
TTTGTGCGCACCGGTATTCCGTGTGCCCATAATAGTGACTATGATATGCAACTGATGCAAGCGGCTCAGATGAATGCCAG
CGACGTGGCAGTGGTTATCTCACATACCGGGCGTAATCAGCAAACACTACAAGTGCTGGCTACCCTGACTTCACAAAGTG
TGCCAGTGATCGCGTTAACTAGCTTCGGTAACTCGCCCCTGGCTAAGGACAGTACCGTTGCCTTTATTTCAGTTGCAGAA
GAAATTAACTATCGTTCGGAAGGGCTGACTTCGTTGATTGCCCAGATGAGTATTATCGATAGTCTCTTCTTGATGACTGC
TGTTCATGGCAATATCGAAATGGCAGAAAGTCTTGGCCGGGTTCGCGAGGCCATTAGTCAAACACGAACGGAGCTTTAA

Upstream 100 bases:

>100_bases
GGACTGGACAGTGTTCAAGAGTTTGTGACGGTGGCACCTGTGAGGAAGTTTAGGGTGTTATTAAGAATTGTGGTAAAATT
TGGTCATGGAGGTGGCCGAA

Downstream 100 bases:

>100_bases
TGCTGTAGGCAAAGGATTGATGAGATGACAAAGCGGCAACATTATCGACCAGTATACGCAAAAACGCGGTGGGCGCGGTG
GCGTTATCGACTGGGCTGGT

Product: transcription regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSTQSPVHRNRVLTLIRSYYPNLSVTDRKIADYIIADPIKTAAQSISDLAAAVGVSTATVSRFVKRISFSSFRDFSRELT
AAEPIEQTNAEAFQDVEKQTTFKGIAESTFNSIRSSLDQTSQVMTEADLKRAVELLLNARSIGFYGLGGSAVAALDGYHK
FVRTGIPCAHNSDYDMQLMQAAQMNASDVAVVISHTGRNQQTLQVLATLTSQSVPVIALTSFGNSPLAKDSTVAFISVAE
EINYRSEGLTSLIAQMSIIDSLFLMTAVHGNIEMAESLGRVREAISQTRTEL

Sequences:

>Translated_292_residues
MSTQSPVHRNRVLTLIRSYYPNLSVTDRKIADYIIADPIKTAAQSISDLAAAVGVSTATVSRFVKRISFSSFRDFSRELT
AAEPIEQTNAEAFQDVEKQTTFKGIAESTFNSIRSSLDQTSQVMTEADLKRAVELLLNARSIGFYGLGGSAVAALDGYHK
FVRTGIPCAHNSDYDMQLMQAAQMNASDVAVVISHTGRNQQTLQVLATLTSQSVPVIALTSFGNSPLAKDSTVAFISVAE
EINYRSEGLTSLIAQMSIIDSLFLMTAVHGNIEMAESLGRVREAISQTRTEL
>Mature_291_residues
STQSPVHRNRVLTLIRSYYPNLSVTDRKIADYIIADPIKTAAQSISDLAAAVGVSTATVSRFVKRISFSSFRDFSRELTA
AEPIEQTNAEAFQDVEKQTTFKGIAESTFNSIRSSLDQTSQVMTEADLKRAVELLLNARSIGFYGLGGSAVAALDGYHKF
VRTGIPCAHNSDYDMQLMQAAQMNASDVAVVISHTGRNQQTLQVLATLTSQSVPVIALTSFGNSPLAKDSTVAFISVAEE
INYRSEGLTSLIAQMSIIDSLFLMTAVHGNIEMAESLGRVREAISQTRTEL

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=279, Percent_Identity=31.1827956989247, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI87082369, Length=267, Percent_Identity=25.4681647940075, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788767, Length=276, Percent_Identity=25, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082130, Length=276, Percent_Identity=24.2753623188406, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31726; Mature: 31595

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQSPVHRNRVLTLIRSYYPNLSVTDRKIADYIIADPIKTAAQSISDLAAAVGVSTATV
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SRFVKRISFSSFRDFSRELTAAEPIEQTNAEAFQDVEKQTTFKGIAESTFNSIRSSLDQT
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQVMTEADLKRAVELLLNARSIGFYGLGGSAVAALDGYHKFVRTGIPCAHNSDYDMQLMQ
HHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
AAQMNASDVAVVISHTGRNQQTLQVLATLTSQSVPVIALTSFGNSPLAKDSTVAFISVAE
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHH
EINYRSEGLTSLIAQMSIIDSLFLMTAVHGNIEMAESLGRVREAISQTRTEL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STQSPVHRNRVLTLIRSYYPNLSVTDRKIADYIIADPIKTAAQSISDLAAAVGVSTATV
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SRFVKRISFSSFRDFSRELTAAEPIEQTNAEAFQDVEKQTTFKGIAESTFNSIRSSLDQT
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQVMTEADLKRAVELLLNARSIGFYGLGGSAVAALDGYHKFVRTGIPCAHNSDYDMQLMQ
HHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
AAQMNASDVAVVISHTGRNQQTLQVLATLTSQSVPVIALTSFGNSPLAKDSTVAFISVAE
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHH
EINYRSEGLTSLIAQMSIIDSLFLMTAVHGNIEMAESLGRVREAISQTRTEL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]