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The map label for this gene is ygcA [C]

Identifier: 28377929

GI number: 28377929

Start: 1048761

End: 1050134

Strand: Direct

Name: ygcA [C]

Synonym: lp_1151

Alternate gene names: 28377929

Gene position: 1048761-1050134 (Clockwise)

Preceding gene: 28377928

Following gene: 28377930

Centisome position: 31.7

GC content: 45.27

Gene sequence:

>1374_bases
ATGAAAGTTAATTTACCAGTGCACAAGGGTGAAGTTTTAGACGTCACTATCATGGATTTAACCTATCAGGGTATGGGTGT
TGCTAAAGTCGATAATTACCCAATCTTTATCGAAAATGCATTGCCAGAAGAAAAAATTACGGTCAAGGTCACGAAGACGA
CGAAGAACTTTGCGTTTGGTGATGTGGAAAAGATTAACCAAGTGAGTCCTCATCGGGTTAATCCTAAAGGGCGCGTTTAT
CGTCAAACCGGGATTGCACCACTACAACACTTGGAATACAGTGAACAATTGAAGTTTAAACAGCACCAGGTGGCCGAATT
ATTTGCAAAGGTCCACATGGATGATGTCGAAGTTTTACCAACGATTGGTATGGCCAACCCGACGCAGTATCGGAACAAGG
CCCAAGTACCCGTACGACAAGTCCAAGGACAACTAACGACTGGTTTTTACAAGAAGAACAGTCATCAATTGATGCCAATT
GAAGATTATTATATTCAAGATCCTGCAATTGATAAGGCTATCGTGGTAGTTCGCGATATTTTACGGAAATATCACGAGGC
AGCCTACGATGAATTCCATCATAGTGGGACGATTCGGACGATCATGGTACGGCGTGGGTATTACAGTCATGAGATGATGG
TTGTTATTGTGACGCGAACGAAACACTTACCAATGGCTGACGTGGTCACACAAGAGATTCAAGCAGCGTTACCTGAAGTT
GTCAGTGTGATTCAAAACGTTAATTCTAAGAAGACTAACGTGATCTTAGGGCCAGTTAACAACGTGTTAGCTGGTAAGGC
CACTATCGATGATCAGTTACTGGGCCTGACATTCGCCATTTCAGCCCAGTCCTTCTATCAAGTGAACCCACAACAGACCG
AAAAGCTTTATCAGTTAGCCATTGATCAAGCTGGTTTGACGGGTAATGAGACGGTGATCGATGCTTATTCCGGTATCGGA
ACGATTTCGTTAACGATGGCCCAACATGCCAAGCAAGTGTATGGTGTTGAAATCGTGCCAGCAGCCATCGATAACGCACG
GCAGAATGCGGATAAGAATGGTATTACGAACGCGACCTTTGTTTTGGATAGCGCTGAAAAAGCCATGGCTAAATGGCAAG
CAGATGGCGTTAAGCCGGACGTGATCGTCGTTGATCCGCCACGTAAGGGCTTGGACGCCGACTTTATCAAGAGTGCCGGT
GAAATGGCGCCTAAACGGGTGGTTTACATTAGTTGTAACCCATCAACCTTAGTTCGAGACGTCCAACGGTTTGCAGAATA
CGGCTACCATATTAGTGCCCCGGTCCAACCCGTGGACCAGTTCCCACAAACACCACATATTGAATCGGTAACGGTGTTAG
AACGCGAACAATAA

Upstream 100 bases:

>100_bases
GGCAGTATTAATGGCCATATCACTCGCTGCCCGGAGCAGTGGCTACCAGGCAGTAACTAAAAAATAATAAGTCACTAACA
AAGAAAGCAAGAGGAAACAA

Downstream 100 bases:

>100_bases
GCATTTTAAAACTGGATTATTAATGAAATTATGAAAAGTGTGTTGGGTGCCTGATTATTTGTCGGGTAACCAACACACTT
TTTTACTCAGCTTGAGGGCT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKVNLPVHKGEVLDVTIMDLTYQGMGVAKVDNYPIFIENALPEEKITVKVTKTTKNFAFGDVEKINQVSPHRVNPKGRVY
RQTGIAPLQHLEYSEQLKFKQHQVAELFAKVHMDDVEVLPTIGMANPTQYRNKAQVPVRQVQGQLTTGFYKKNSHQLMPI
EDYYIQDPAIDKAIVVVRDILRKYHEAAYDEFHHSGTIRTIMVRRGYYSHEMMVVIVTRTKHLPMADVVTQEIQAALPEV
VSVIQNVNSKKTNVILGPVNNVLAGKATIDDQLLGLTFAISAQSFYQVNPQQTEKLYQLAIDQAGLTGNETVIDAYSGIG
TISLTMAQHAKQVYGVEIVPAAIDNARQNADKNGITNATFVLDSAEKAMAKWQADGVKPDVIVVDPPRKGLDADFIKSAG
EMAPKRVVYISCNPSTLVRDVQRFAEYGYHISAPVQPVDQFPQTPHIESVTVLEREQ

Sequences:

>Translated_457_residues
MKVNLPVHKGEVLDVTIMDLTYQGMGVAKVDNYPIFIENALPEEKITVKVTKTTKNFAFGDVEKINQVSPHRVNPKGRVY
RQTGIAPLQHLEYSEQLKFKQHQVAELFAKVHMDDVEVLPTIGMANPTQYRNKAQVPVRQVQGQLTTGFYKKNSHQLMPI
EDYYIQDPAIDKAIVVVRDILRKYHEAAYDEFHHSGTIRTIMVRRGYYSHEMMVVIVTRTKHLPMADVVTQEIQAALPEV
VSVIQNVNSKKTNVILGPVNNVLAGKATIDDQLLGLTFAISAQSFYQVNPQQTEKLYQLAIDQAGLTGNETVIDAYSGIG
TISLTMAQHAKQVYGVEIVPAAIDNARQNADKNGITNATFVLDSAEKAMAKWQADGVKPDVIVVDPPRKGLDADFIKSAG
EMAPKRVVYISCNPSTLVRDVQRFAEYGYHISAPVQPVDQFPQTPHIESVTVLEREQ
>Mature_457_residues
MKVNLPVHKGEVLDVTIMDLTYQGMGVAKVDNYPIFIENALPEEKITVKVTKTTKNFAFGDVEKINQVSPHRVNPKGRVY
RQTGIAPLQHLEYSEQLKFKQHQVAELFAKVHMDDVEVLPTIGMANPTQYRNKAQVPVRQVQGQLTTGFYKKNSHQLMPI
EDYYIQDPAIDKAIVVVRDILRKYHEAAYDEFHHSGTIRTIMVRRGYYSHEMMVVIVTRTKHLPMADVVTQEIQAALPEV
VSVIQNVNSKKTNVILGPVNNVLAGKATIDDQLLGLTFAISAQSFYQVNPQQTEKLYQLAIDQAGLTGNETVIDAYSGIG
TISLTMAQHAKQVYGVEIVPAAIDNARQNADKNGITNATFVLDSAEKAMAKWQADGVKPDVIVVDPPRKGLDADFIKSAG
EMAPKRVVYISCNPSTLVRDVQRFAEYGYHISAPVQPVDQFPQTPHIESVTVLEREQ

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=447, Percent_Identity=28.8590604026846, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI51173878, Length=447, Percent_Identity=28.8590604026846, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI269784680, Length=287, Percent_Identity=27.8745644599303, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI269784676, Length=287, Percent_Identity=27.8745644599303, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI20149688, Length=287, Percent_Identity=27.8745644599303, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI269784678, Length=287, Percent_Identity=27.8745644599303, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789148, Length=452, Percent_Identity=28.0973451327434, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787083, Length=366, Percent_Identity=25.1366120218579, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790403, Length=183, Percent_Identity=30.0546448087432, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322909, Length=443, Percent_Identity=25.9593679458239, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24666579, Length=434, Percent_Identity=32.0276497695853, Blast_Score=161, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1151_LACPL (Q88XP4)

Other databases:

- EMBL:   AL935255
- RefSeq:   NP_784821.1
- ProteinModelPortal:   Q88XP4
- GeneID:   1063225
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1151
- NMPDR:   fig|220668.1.peg.955
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- ProtClustDB:   CLSK821262
- BioCyc:   LPLA220668:LP_1151-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 51004; Mature: 51004

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 412-412 BINDING 287-287 BINDING 316-316 BINDING 337-337 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNLPVHKGEVLDVTIMDLTYQGMGVAKVDNYPIFIENALPEEKITVKVTKTTKNFAFG
CEECCCCCCCCEEEEEEEEEEECCCCEEEECCCCEEEECCCCCCEEEEEEEECCCCCCCC
DVEKINQVSPHRVNPKGRVYRQTGIAPLQHLEYSEQLKFKQHQVAELFAKVHMDDVEVLP
CHHHHHCCCCCCCCCCCCEEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHC
TIGMANPTQYRNKAQVPVRQVQGQLTTGFYKKNSHQLMPIEDYYIQDPAIDKAIVVVRDI
CCCCCCCHHHCCCCCCCHHHHCCCHHCCEEECCCCCCCCCHHHEECCCCCCHHHHHHHHH
LRKYHEAAYDEFHHSGTIRTIMVRRGYYSHEMMVVIVTRTKHLPMADVVTQEIQAALPEV
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
VSVIQNVNSKKTNVILGPVNNVLAGKATIDDQLLGLTFAISAQSFYQVNPQQTEKLYQLA
HHHHHCCCCCCCEEEECCCCCHHCCCCCCCCHHEEEEEEEECCCEEECCHHHHHHHHHHH
IDQAGLTGNETVIDAYSGIGTISLTMAQHAKQVYGVEIVPAAIDNARQNADKNGITNATF
HHHCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHCEEEEHHHHHHHHHCCCCCCCCEEEE
VLDSAEKAMAKWQADGVKPDVIVVDPPRKGLDADFIKSAGEMAPKRVVYISCNPSTLVRD
EEECHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECHHHHHHH
VQRFAEYGYHISAPVQPVDQFPQTPHIESVTVLEREQ
HHHHHHCCEEEECCCCHHHHCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MKVNLPVHKGEVLDVTIMDLTYQGMGVAKVDNYPIFIENALPEEKITVKVTKTTKNFAFG
CEECCCCCCCCEEEEEEEEEEECCCCEEEECCCCEEEECCCCCCEEEEEEEECCCCCCCC
DVEKINQVSPHRVNPKGRVYRQTGIAPLQHLEYSEQLKFKQHQVAELFAKVHMDDVEVLP
CHHHHHCCCCCCCCCCCCEEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHC
TIGMANPTQYRNKAQVPVRQVQGQLTTGFYKKNSHQLMPIEDYYIQDPAIDKAIVVVRDI
CCCCCCCHHHCCCCCCCHHHHCCCHHCCEEECCCCCCCCCHHHEECCCCCCHHHHHHHHH
LRKYHEAAYDEFHHSGTIRTIMVRRGYYSHEMMVVIVTRTKHLPMADVVTQEIQAALPEV
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
VSVIQNVNSKKTNVILGPVNNVLAGKATIDDQLLGLTFAISAQSFYQVNPQQTEKLYQLA
HHHHHCCCCCCCEEEECCCCCHHCCCCCCCCHHEEEEEEEECCCEEECCHHHHHHHHHHH
IDQAGLTGNETVIDAYSGIGTISLTMAQHAKQVYGVEIVPAAIDNARQNADKNGITNATF
HHHCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHCEEEEHHHHHHHHHCCCCCCCCEEEE
VLDSAEKAMAKWQADGVKPDVIVVDPPRKGLDADFIKSAGEMAPKRVVYISCNPSTLVRD
EEECHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECHHHHHHH
VQRFAEYGYHISAPVQPVDQFPQTPHIESVTVLEREQ
HHHHHHCCEEEECCCCHHHHCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566