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The map label for this gene is adk

Identifier: 28377853

GI number: 28377853

Start: 963427

End: 964077

Strand: Direct

Name: adk

Synonym: lp_1058

Alternate gene names: 28377853

Gene position: 963427-964077 (Clockwise)

Preceding gene: 28377852

Following gene: 28377854

Centisome position: 29.12

GC content: 42.55

Gene sequence:

>651_bases
ATGAACCTGATTTTAATGGGATTACCGGGTGCCGGTAAGGGTACTCAAGCACAGAAGATTCTTGAAGATTTTGATATTCC
ACATATCTCGACCGGAGATATCTTCCGTGCAGCCATTAAGAACGAAACGAAGATGGGCTTGGAAGCCAAGAAGTATATTG
ATGCAGGTAACTTAGTACCAGACGAAGTCACTAACGGCATCGTCCGTGATCGGTTAGCTGAAGCGGATACTAAAAATGGT
TTCCTATTAGATGGTTACCCACGTAACATCGATCAAGCTCATGCTTTGAAACAAATCGGTGAAGAACTCAATAAGCCACT
TGATGGGGTCATCAACATTCATGTTGAACCCGCAGTACTTGTTGAACGACTTTCCGGTCGGTTTATCTGCCGGACTTGCG
GTGCAACTTACCATAAGTTGTACAACAAGCCTAAGGTAGAAGGAACCTGTGATGTGTGTGGCGGTCATGATTTCTATCAA
CGTGATGATGACAAGCCAGCAACCGTTAAGAATCGGTTAGACGTGAACATTAAGTTGAACACGCCATTAATTGATTATTA
CGGTCAAGAAAAGTTACTCTACAATGTCGACGGTGATCGCGACATTGATGATGTCTACAAAGATATCAAGAAAATTCTTG
ATAACCTGTAA

Upstream 100 bases:

>100_bases
GATGATGAAACGTGACTATGTCGGTTTCATTCGTTAATCAGCGAATGTGTTGGGGAGACTCAACACATTTGTGCATTCAG
GAGGAAAAAACATGTCAACA

Downstream 100 bases:

>100_bases
ACCAGGTTCCTTCAGCAGCGACGTTTGCTTTTCAAAGGTCGTTGTGATAAAATTATTCAGGTTTAGCCGTTGACTGATTT
AATATTTTTTTAATGTTATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNLILMGLPGAGKGTQAQKILEDFDIPHISTGDIFRAAIKNETKMGLEAKKYIDAGNLVPDEVTNGIVRDRLAEADTKNG
FLLDGYPRNIDQAHALKQIGEELNKPLDGVINIHVEPAVLVERLSGRFICRTCGATYHKLYNKPKVEGTCDVCGGHDFYQ
RDDDKPATVKNRLDVNIKLNTPLIDYYGQEKLLYNVDGDRDIDDVYKDIKKILDNL

Sequences:

>Translated_216_residues
MNLILMGLPGAGKGTQAQKILEDFDIPHISTGDIFRAAIKNETKMGLEAKKYIDAGNLVPDEVTNGIVRDRLAEADTKNG
FLLDGYPRNIDQAHALKQIGEELNKPLDGVINIHVEPAVLVERLSGRFICRTCGATYHKLYNKPKVEGTCDVCGGHDFYQ
RDDDKPATVKNRLDVNIKLNTPLIDYYGQEKLLYNVDGDRDIDDVYKDIKKILDNL
>Mature_216_residues
MNLILMGLPGAGKGTQAQKILEDFDIPHISTGDIFRAAIKNETKMGLEAKKYIDAGNLVPDEVTNGIVRDRLAEADTKNG
FLLDGYPRNIDQAHALKQIGEELNKPLDGVINIHVEPAVLVERLSGRFICRTCGATYHKLYNKPKVEGTCDVCGGHDFYQ
RDDDKPATVKNRLDVNIKLNTPLIDYYGQEKLLYNVDGDRDIDDVYKDIKKILDNL

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=37.378640776699, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=37.378640776699, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI19923437, Length=202, Percent_Identity=36.6336633663366, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI310110345, Length=217, Percent_Identity=34.5622119815668, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI53832003, Length=217, Percent_Identity=34.5622119815668, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI8051579, Length=217, Percent_Identity=34.5622119815668, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI53832001, Length=217, Percent_Identity=34.5622119815668, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4502011, Length=218, Percent_Identity=27.9816513761468, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=27.1889400921659, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=222, Percent_Identity=26.5765765765766, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI28144897, Length=222, Percent_Identity=26.5765765765766, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI22749187, Length=210, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=44.954128440367, Blast_Score=178, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=34.2592592592593, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=28.9719626168224, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=28.3720930232558, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=219, Percent_Identity=26.4840182648402, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=25.8215962441315, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=39.5238095238095, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.5329949238579, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=218, Percent_Identity=28.4403669724771, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=40.3755868544601, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=36.5482233502538, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=36.5482233502538, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24663208, Length=213, Percent_Identity=25.8215962441315, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647141, Length=213, Percent_Identity=25.8215962441315, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=26.7605633802817, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=26.7605633802817, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_LACPL (Q88XW5)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784745.1
- ProteinModelPortal:   Q88XW5
- SMR:   Q88XW5
- GeneID:   1063477
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1058
- NMPDR:   fig|220668.1.peg.879
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   CLSK2520138
- BioCyc:   LPLA220668:LP_1058-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24143; Mature: 24143

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILMGLPGAGKGTQAQKILEDFDIPHISTGDIFRAAIKNETKMGLEAKKYIDAGNLVP
CCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHCCCHHHHHHCCCCCCH
DEVTNGIVRDRLAEADTKNGFLLDGYPRNIDQAHALKQIGEELNKPLDGVINIHVEPAVL
HHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECHHHH
VERLSGRFICRTCGATYHKLYNKPKVEGTCDVCGGHDFYQRDDDKPATVKNRLDVNIKLN
HHHHCCCEEEHHHCHHHHHHHCCCCCCCEEECCCCCHHHCCCCCCCCCCCCEEEEEEEEC
TPLIDYYGQEKLLYNVDGDRDIDDVYKDIKKILDNL
CCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLILMGLPGAGKGTQAQKILEDFDIPHISTGDIFRAAIKNETKMGLEAKKYIDAGNLVP
CCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHCCCHHHHHHCCCCCCH
DEVTNGIVRDRLAEADTKNGFLLDGYPRNIDQAHALKQIGEELNKPLDGVINIHVEPAVL
HHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECHHHH
VERLSGRFICRTCGATYHKLYNKPKVEGTCDVCGGHDFYQRDDDKPATVKNRLDVNIKLN
HHHHCCCEEEHHHCHHHHHHHCCCCCCCEEECCCCCHHHCCCCCCCCCCCCEEEEEEEEC
TPLIDYYGQEKLLYNVDGDRDIDDVYKDIKKILDNL
CCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566