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The map label for this gene is argJ

Identifier: 28377415

GI number: 28377415

Start: 478016

End: 479230

Strand: Direct

Name: argJ

Synonym: lp_0529

Alternate gene names: 28377415

Gene position: 478016-479230 (Clockwise)

Preceding gene: 28377414

Following gene: 28377416

Centisome position: 14.45

GC content: 47.49

Gene sequence:

>1215_bases
ATGCAGATGCAAGTTTTAACGAATACGAAGTTTGAAACGGTTGCCTTTCAGTGGCCGGCAGGTTTTTACAGTGATGGCAT
TCATATTGGTCTTCGTCGTCATAAAAAAGATTTTGGTTGGCTATTTTCAAAAGTGCCTGCCAGTGCGGCTGGAACTTATA
CGACGAATCAGTTTCAGGCAGCACCAACTAAGTTAACTAAACAGATGATCGACCAGGGCCACCAATTACAGGGACTGCTG
CTGAATAGTGCAATCGCCAATTCTTGTACTGGCGAGCAGGGGTGGCAGAATGCGCTGCAAGAACAAGCCTGGTTAGCGAA
TAAACTAAACGTGGCGCCGAACTTGATTGGCGTTGCTTCCACTGGGCTGATTGGTGCTCAGTTACCCATGGATAAAATCA
AAAACGGCTTGCCGCAATTGACACCAACGAAGAGTGACGCGGTGACCTACGCCGTGTTAACGACAGACCAGCATCCAAAA
ACCGTCTGTGTGCAGTGTGAACTCAGCGGCCAGTTAGTTACCTTGACCGGTTTTGCCAAAGGTTCTGGAATGATTCATCC
CAAGATGGCAACCATGCTTGGTTTTGTCACCACCGATGCCCAAATAGACGGGCCAGTTTTACAGGACATGCTAAGTACTA
ACGTTGATCAGACATTCAATCAAATTACTGTTGACGGTGACACGTCTACTAATGACATGGTGGTCACGTTGGCGAATGGT
CTGGCAGATAATCCGAGTTTACAAGCGGGTACCACCGACTATGATATTTTTAATCAGGCGTTGCACTATGTCTTAGGCCA
ACTTGCCAAGCAAATTGCCGCTGACGGTGAGGGTGCGACCAAGTTAGTCGAATGTAATGTGGTCCACGCCGCTACAACGT
TTGATGGTCAGCAAATCGCCAAAGCAATTGTTGGCTCTAACCTCGTTAAGGCGGCCATTTTCGGTGAAGACCCGAATTGG
GGGCGAATCATTAGCACGATTGGCGCCACTGATGCAGACATCGATGTGGCGACGGTCGATATTGAAATGAACGGCGTTTT
ACTTGTTCAACAAAGTCTGGCCGTTGACTTTGATATGGCAGCGGTGCAGGCGACCTTACGTGATAACCAGATTATGATCG
ATGTTGATTTACATCACGGTACAGCAAGTGGTCAGGCTTGGGGTTGTGACTTGACTTACAACTACGTCAAAATTAACGCG
AGCTATCATACTTAA

Upstream 100 bases:

>100_bases
GGCCGTTCAGAATTTTAATCGCTATTTTGATTTCGCGGTTACGGCCGGATTACCGACGTTACCTGTATTTCCCTGATAAG
GTGCAATAAGAGAGGAAGTT

Downstream 100 bases:

>100_bases
ACGGAGGTGGTGAAAATGACAAAATTGATTGTAATTAAGATTGGGGGCCAGGCGATTAGCCAATTGAGCACCACTTTCTT
TGACCAAATCGCACAGTGGT

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQMQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQAAPTKLTKQMIDQGHQLQGLL
LNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVASTGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPK
TVCVQCELSGQLVTLTGFAKGSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANG
LADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIAKAIVGSNLVKAAIFGEDPNW
GRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMAAVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINA
SYHT

Sequences:

>Translated_404_residues
MQMQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQAAPTKLTKQMIDQGHQLQGLL
LNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVASTGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPK
TVCVQCELSGQLVTLTGFAKGSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANG
LADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIAKAIVGSNLVKAAIFGEDPNW
GRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMAAVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINA
SYHT
>Mature_404_residues
MQMQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQAAPTKLTKQMIDQGHQLQGLL
LNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVASTGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPK
TVCVQCELSGQLVTLTGFAKGSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANG
LADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIAKAIVGSNLVKAAIFGEDPNW
GRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMAAVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINA
SYHT

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=415, Percent_Identity=35.6626506024096, Blast_Score=225, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ_LACPL (O08319)

Other databases:

- EMBL:   X99978
- EMBL:   AL935253
- RefSeq:   NP_784307.1
- ProteinModelPortal:   O08319
- SMR:   O08319
- MEROPS:   T05.001
- GeneID:   1061854
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0529
- NMPDR:   fig|220668.1.peg.441
- HOGENOM:   HBG284202
- OMA:   QNRFCAA
- ProtClustDB:   PRK05388
- BioCyc:   LPLA220668:LP_0529-MONOMER
- BRENDA:   2.3.1.1
- BRENDA:   2.3.1.35
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 43276; Mature: 43276

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQA
CEEEEEECCCEEEEEEECCCCCCCCCEEEEHHHCCCHHHHHHHHCCCCCCCCEECCCEEC
APTKLTKQMIDQGHQLQGLLLNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVAS
CHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECC
TGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPKTVCVQCELSGQLVTLTGFAK
CCCEECCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCEEEEEEEEC
GSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANG
CCCCCCHHHHHHHHEEECCCCCCCHHHHHHHHCCHHCCCCEEEECCCCCCCCEEEEEECC
LADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHH
KAIVGSNLVKAAIFGEDPNWGRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMA
HHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCCCEEEEEEEEECCEEEEEECCCCCHHHH
AVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINASYHT
HHHHEECCCEEEEEEEECCCCCCCCEEEEEEEEEEEEEEEECCC
>Mature Secondary Structure
MQMQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQA
CEEEEEECCCEEEEEEECCCCCCCCCEEEEHHHCCCHHHHHHHHCCCCCCCCEECCCEEC
APTKLTKQMIDQGHQLQGLLLNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVAS
CHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECC
TGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPKTVCVQCELSGQLVTLTGFAK
CCCEECCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCEEEEEEEEC
GSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANG
CCCCCCHHHHHHHHEEECCCCCCCHHHHHHHHCCHHCCCCEEEECCCCCCCCEEEEEECC
LADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHH
KAIVGSNLVKAAIFGEDPNWGRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMA
HHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCCCEEEEEEEEECCEEEEEECCCCCHHHH
AVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINASYHT
HHHHEECCCEEEEEEEECCCCCCCCEEEEEEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9098069; 12566566