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The map label for this gene is argB

Identifier: 28377416

GI number: 28377416

Start: 479246

End: 479992

Strand: Direct

Name: argB

Synonym: lp_0530

Alternate gene names: 28377416

Gene position: 479246-479992 (Clockwise)

Preceding gene: 28377415

Following gene: 28377417

Centisome position: 14.49

GC content: 48.33

Gene sequence:

>747_bases
ATGACAAAATTGATTGTAATTAAGATTGGGGGCCAGGCGATTAGCCAATTGAGCACCACTTTCTTTGACCAAATCGCACA
GTGGTACCAACAGCATTATCAGATTCTGATCGTACACGGTGGGGGGCCAATGATCAATCGACTGACGACTCAGCTTGCTT
TGCCCGTGCATAAGGTGAACGGGTTGCGGGTGACGGATGCGGCGACCTTAGTGCTCACCAAGTTGGCCCTGCTAGGAGAT
GCGCAACCAGCCTTACTTGCAAAATTAACGCAACATCACCTACCTGTGTTGGGGCTCAATGCGGCGGATAATCAGTTACT
AACTGGTGAATTGATTGATTATCGACAGCTAGGGTATGTCGGCCGGCTCACCGCTGTCAATCAAGTGCAATTAATGCAAT
TGTTGGCTCATCATATCGGTATTTTGGCCCCTTTAGCCTTAACCGAGACGGGACAATGGCTCAATGTCAATGCGGATATG
GCAGCGACCGTGCTAGCTCAACAACTACATGCTGAAAAATTGGTTTTGCTAACCGATGTCCCGGGAATTATACATCACGG
TAATGTGATGACATCACTATCGCCACAACAAGCTCAGCAATTGATTCGAACAGCTGTGATCACCGCGGGAATGCAACCCA
AAGTTCAAGCTGCAATTGCCGCGATTCAGACGGGAGTCAAGCAGGCTATTATTACGAATGCAATCGATCAACCAGGAACC
GCAATTATTCAGGAGGTGGCCGTATGA

Upstream 100 bases:

>100_bases
ACATCACGGTACAGCAAGTGGTCAGGCTTGGGGTTGTGACTTGACTTACAACTACGTCAAAATTAACGCGAGCTATCATA
CTTAAACGGAGGTGGTGAAA

Downstream 100 bases:

>100_bases
CCATGCAACACGTGTTTCCAACCTATCAACGTTTTCCATTTGCCATTACGGATGGTCAGGGCGTTCATCTGACTGATAAT
CATGGCAAGACGTATTTAGA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTKLIVIKIGGQAISQLSTTFFDQIAQWYQQHYQILIVHGGGPMINRLTTQLALPVHKVNGLRVTDAATLVLTKLALLGD
AQPALLAKLTQHHLPVLGLNAADNQLLTGELIDYRQLGYVGRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADM
AATVLAQQLHAEKLVLLTDVPGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAIQTGVKQAIITNAIDQPGT
AIIQEVAV

Sequences:

>Translated_248_residues
MTKLIVIKIGGQAISQLSTTFFDQIAQWYQQHYQILIVHGGGPMINRLTTQLALPVHKVNGLRVTDAATLVLTKLALLGD
AQPALLAKLTQHHLPVLGLNAADNQLLTGELIDYRQLGYVGRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADM
AATVLAQQLHAEKLVLLTDVPGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAIQTGVKQAIITNAIDQPGT
AIIQEVAV
>Mature_247_residues
TKLIVIKIGGQAISQLSTTFFDQIAQWYQQHYQILIVHGGGPMINRLTTQLALPVHKVNGLRVTDAATLVLTKLALLGDA
QPALLAKLTQHHLPVLGLNAADNQLLTGELIDYRQLGYVGRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADMA
ATVLAQQLHAEKLVLLTDVPGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAIQTGVKQAIITNAIDQPGTA
IIQEVAV

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI145693208, Length=229, Percent_Identity=35.3711790393013, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789181, Length=260, Percent_Identity=26.5384615384615, Blast_Score=68, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320913, Length=187, Percent_Identity=31.5508021390374, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGB_LACPL (O08320)

Other databases:

- EMBL:   X99978
- EMBL:   AL935253
- RefSeq:   NP_784308.1
- ProteinModelPortal:   O08320
- SMR:   O08320
- GeneID:   1061853
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0530
- NMPDR:   fig|220668.1.peg.442
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- ProtClustDB:   PRK00942
- BioCyc:   LPLA220668:LP_0530-MONOMER
- BRENDA:   2.7.2.8
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 26590; Mature: 26458

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: BINDING 63-63 BINDING 155-155

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLIVIKIGGQAISQLSTTFFDQIAQWYQQHYQILIVHGGGPMINRLTTQLALPVHKVN
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCC
GLRVTDAATLVLTKLALLGDAQPALLAKLTQHHLPVLGLNAADNQLLTGELIDYRQLGYV
CEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCEEEHHHHHHHHHCCH
GRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADMAATVLAQQLHAEKLVLLTDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHEEEEECC
PGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAIQTGVKQAIITNAIDQPGT
CCHHCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AIIQEVAV
HHHHHHCC
>Mature Secondary Structure 
TKLIVIKIGGQAISQLSTTFFDQIAQWYQQHYQILIVHGGGPMINRLTTQLALPVHKVN
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCC
GLRVTDAATLVLTKLALLGDAQPALLAKLTQHHLPVLGLNAADNQLLTGELIDYRQLGYV
CEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCEEEHHHHHHHHHCCH
GRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADMAATVLAQQLHAEKLVLLTDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHEEEEECC
PGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAIQTGVKQAIITNAIDQPGT
CCHHCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AIIQEVAV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9098069; 12566566