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The map label for this gene is sdhA [H]

Identifier: 28377395

GI number: 28377395

Start: 452759

End: 453658

Strand: Direct

Name: sdhA [H]

Synonym: lp_0506

Alternate gene names: 28377395

Gene position: 452759-453658 (Clockwise)

Preceding gene: 28377394

Following gene: 28377396

Centisome position: 13.69

GC content: 50.22

Gene sequence:

>900_bases
ATGTACATGAGCGTAGCAGAACTGGTAACAGCGGCCAAGGAGACCAAGAAGCCGATCTACGAATTAATGATTGAACAAGA
GATGGAAACATCGCAAACGAGTCGCGAAGAAATCTGGCACACGATGGGCCGGAATCTAGACGTCATGGAAGCAGCTGTTA
ATAAAGGGGCTGCAGGCGACGGGGTCTATTCAACAACTGGTTTAACTGGTGGTGAAGCTGTTCTCTTGAAAAAGTATCGT
CAAAAAGGGCACACTTTATCCGGCGATACGATGATGCAAGCTGTTCAGAACGCAATCTCAACCAATGAAGTTAATGCTTC
GATGGGAGTCGTTTGTGCGACACCAACGGCTGGATCGACGGGGACACTACCTGGTGTGATTTTCACGCTGAAGGACCGAA
TGAACCTCAACCGTGACCAGATGATCCAATTTCTATTTACCGCTGGCGCTTTTGGGATGGTCATAGCTAATAATGCTGGG
ATTGCTGGTGCGACTGGCGGTTGCCAAGCTGAAGTTGGTAGCGCTTCTGCGATGGGCGCTGCGGCCGCGGTTGAAGTTGC
TGGTGGGACGCCTGAACAAAGTGCTGAGGCTTTGGCGATGGCAATCAGTAACTTGATGGGATTAGTGTGTGATCCCGTTG
CTGGGTTAGTTGAACTACCGTGTGTTAAACGGAATGCGATTGGGGTCGGTAATGCGTTGATTGCGGCTGACATGGCTTTG
GCTGGCTGCACGAACAAGATTCCAGCGGATGAAGTCATTGCAGCGATGGATAAAGTCGGTAAGGGCTTGCCAAAGGCACT
TCGGGAAACTGGACTGGGTGGCTTAGCGGCGACGCCAACCGGTATTCGGATGAAGGAAAAGATTTTTGGACGATCGACTA
ATTCACAAGTTCATGCATAA

Upstream 100 bases:

>100_bases
TGAATATGATTTGGATCGCCGCCTCAAACAGGATGAAATCAAAAAATTAGCGCAGGGACACGCAAATTTAGTTTACTTAT
AATCAGGGAGGTCAGTTATG

Downstream 100 bases:

>100_bases
AAATGTCGCAGAAAGATGATGAGCTGACTAAAGGCGGTATCATCTTTTTTAATTAGATGTTTATATCGTTACATGTATTA
ACATTTTATCAGTGTGATAA

Product: L-serine dehydratase, alpha subunit

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MYMSVAELVTAAKETKKPIYELMIEQEMETSQTSREEIWHTMGRNLDVMEAAVNKGAAGDGVYSTTGLTGGEAVLLKKYR
QKGHTLSGDTMMQAVQNAISTNEVNASMGVVCATPTAGSTGTLPGVIFTLKDRMNLNRDQMIQFLFTAGAFGMVIANNAG
IAGATGGCQAEVGSASAMGAAAAVEVAGGTPEQSAEALAMAISNLMGLVCDPVAGLVELPCVKRNAIGVGNALIAADMAL
AGCTNKIPADEVIAAMDKVGKGLPKALRETGLGGLAATPTGIRMKEKIFGRSTNSQVHA

Sequences:

>Translated_299_residues
MYMSVAELVTAAKETKKPIYELMIEQEMETSQTSREEIWHTMGRNLDVMEAAVNKGAAGDGVYSTTGLTGGEAVLLKKYR
QKGHTLSGDTMMQAVQNAISTNEVNASMGVVCATPTAGSTGTLPGVIFTLKDRMNLNRDQMIQFLFTAGAFGMVIANNAG
IAGATGGCQAEVGSASAMGAAAAVEVAGGTPEQSAEALAMAISNLMGLVCDPVAGLVELPCVKRNAIGVGNALIAADMAL
AGCTNKIPADEVIAAMDKVGKGLPKALRETGLGGLAATPTGIRMKEKIFGRSTNSQVHA
>Mature_299_residues
MYMSVAELVTAAKETKKPIYELMIEQEMETSQTSREEIWHTMGRNLDVMEAAVNKGAAGDGVYSTTGLTGGEAVLLKKYR
QKGHTLSGDTMMQAVQNAISTNEVNASMGVVCATPTAGSTGTLPGVIFTLKDRMNLNRDQMIQFLFTAGAFGMVIANNAG
IAGATGGCQAEVGSASAMGAAAAVEVAGGTPEQSAEALAMAISNLMGLVCDPVAGLVELPCVKRNAIGVGNALIAADMAL
AGCTNKIPADEVIAAMDKVGKGLPKALRETGLGGLAATPTGIRMKEKIFGRSTNSQVHA

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=280, Percent_Identity=33.9285714285714, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1789161, Length=282, Percent_Identity=34.3971631205674, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1788116, Length=280, Percent_Identity=34.2857142857143, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 30760; Mature: 30760

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMSVAELVTAAKETKKPIYELMIEQEMETSQTSREEIWHTMGRNLDVMEAAVNKGAAGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
GVYSTTGLTGGEAVLLKKYRQKGHTLSGDTMMQAVQNAISTNEVNASMGVVCATPTAGST
CCEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
GTLPGVIFTLKDRMNLNRDQMIQFLFTAGAFGMVIANNAGIAGATGGCQAEVGSASAMGA
CCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHCH
AAAVEVAGGTPEQSAEALAMAISNLMGLVCDPVAGLVELPCVKRNAIGVGNALIAADMAL
HHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AGCTNKIPADEVIAAMDKVGKGLPKALRETGLGGLAATPTGIRMKEKIFGRSTNSQVHA
HCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYMSVAELVTAAKETKKPIYELMIEQEMETSQTSREEIWHTMGRNLDVMEAAVNKGAAGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
GVYSTTGLTGGEAVLLKKYRQKGHTLSGDTMMQAVQNAISTNEVNASMGVVCATPTAGST
CCEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
GTLPGVIFTLKDRMNLNRDQMIQFLFTAGAFGMVIANNAGIAGATGGCQAEVGSASAMGA
CCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHCH
AAAVEVAGGTPEQSAEALAMAISNLMGLVCDPVAGLVELPCVKRNAIGVGNALIAADMAL
HHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AGCTNKIPADEVIAAMDKVGKGLPKALRETGLGGLAATPTGIRMKEKIFGRSTNSQVHA
HCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]