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The map label for this gene is trpS [H]

Identifier: 28377337

GI number: 28377337

Start: 387822

End: 388838

Strand: Direct

Name: trpS [H]

Synonym: lp_0434

Alternate gene names: 28377337

Gene position: 387822-388838 (Clockwise)

Preceding gene: 28377336

Following gene: 28377338

Centisome position: 11.72

GC content: 45.43

Gene sequence:

>1017_bases
ATGACAAAAAAAGTGATTTTAACGGGTGATCGCCCCACTGGTAAGCTGCATATCGGGCACTATGTCGGTTCATTACGTAA
CCGGGTCGCATTACAAGATTCTGGGGACTATGACTCATACATTATGATTGCGGATAACCAGGCGTTGACGGATAATGCGC
ATGATCCCGAAAAAATTCGTAAAAGTTTATTACAAGTTGCGATGGACTACTTGGCAGTGGGAATCGATCCCCAAAAGTCA
ACGATCTTAGTCCAGTCTCAAATTCCAGCATTAACTGACATGATGAATCAATACTTGAACTTAGTGACGGTAGCGCGCTT
GAATCGTAACCCAACTGTGAAGACGGAAATCAAGCAAAAAGCTTTTGGTGAAAGTGTTCCTGCCGGTTTCTTTGTTTATC
CAGTCAGTCAGGCCGCTGATATTACGGCTTTCAAGGCGACGACTGTTCCCGTTGGTGACGATCAAGAACCAATGCTTGAA
CAGACCCGTGAAATCGTACGGAGCTTCAATAAGACTTACCAAACTGACACGTTGGTTGAACCTGAAGGCTACTTCCCACC
AAAGGGCTTGGGCCGAATCCCTGGACTTGACGGCAATGCCAAAATGAGTAAATCACTAGGAAATGCGATTTACCTTTCTG
ACGATGCCGATACTTTGAAGAAGAAAGTCATGTCCATGTATACCGATCCTGATCATATTCATATTGAAGATCCGGGTAAG
GTCGAAGGTAACGTGGTCTTCACGTATCTTGATATTTTCGATGAAGACAAGGCCAAGGTCGCAGACTTGAAGGCCGCCTA
CCAACATGGTGGCTTGGGTGACGTTAAGATTAAACGCTACTTGATGGACGTGTTGGACGGTGTATTGCGGCCAATCCGCG
AACGGCGTGCAATTTACGAAGCTGATCCAGCTCAAGTCTTACAAATTTTGAAGGATGGTACAGCGAAAGCGAACGTGGTC
GCTGACCAAACGTGGCGTGAGATGCAAGACGCCATTGGAATTAATTATTTTGAATAA

Upstream 100 bases:

>100_bases
AAGCTTTCTGCAATTTAGGTGGTACCACGGTGATGCGTCCTAATTAACTAGTATTAGTTGATCAGGCGCTTTTTTAGTGC
CAATAGAAAGGATGAATACA

Downstream 100 bases:

>100_bases
ATCATGGTAGAAAATAGTGCAACTGACCGTCGGATGTGTGAAGACGGTGAGTTGCACTTTTTTGTAGACCCTTAATATAT
GGGGCTTTCCGGTAAATTAA

Product: tryptophanyl-tRNA synthetase II

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTKKVILTGDRPTGKLHIGHYVGSLRNRVALQDSGDYDSYIMIADNQALTDNAHDPEKIRKSLLQVAMDYLAVGIDPQKS
TILVQSQIPALTDMMNQYLNLVTVARLNRNPTVKTEIKQKAFGESVPAGFFVYPVSQAADITAFKATTVPVGDDQEPMLE
QTREIVRSFNKTYQTDTLVEPEGYFPPKGLGRIPGLDGNAKMSKSLGNAIYLSDDADTLKKKVMSMYTDPDHIHIEDPGK
VEGNVVFTYLDIFDEDKAKVADLKAAYQHGGLGDVKIKRYLMDVLDGVLRPIRERRAIYEADPAQVLQILKDGTAKANVV
ADQTWREMQDAIGINYFE

Sequences:

>Translated_338_residues
MTKKVILTGDRPTGKLHIGHYVGSLRNRVALQDSGDYDSYIMIADNQALTDNAHDPEKIRKSLLQVAMDYLAVGIDPQKS
TILVQSQIPALTDMMNQYLNLVTVARLNRNPTVKTEIKQKAFGESVPAGFFVYPVSQAADITAFKATTVPVGDDQEPMLE
QTREIVRSFNKTYQTDTLVEPEGYFPPKGLGRIPGLDGNAKMSKSLGNAIYLSDDADTLKKKVMSMYTDPDHIHIEDPGK
VEGNVVFTYLDIFDEDKAKVADLKAAYQHGGLGDVKIKRYLMDVLDGVLRPIRERRAIYEADPAQVLQILKDGTAKANVV
ADQTWREMQDAIGINYFE
>Mature_337_residues
TKKVILTGDRPTGKLHIGHYVGSLRNRVALQDSGDYDSYIMIADNQALTDNAHDPEKIRKSLLQVAMDYLAVGIDPQKST
ILVQSQIPALTDMMNQYLNLVTVARLNRNPTVKTEIKQKAFGESVPAGFFVYPVSQAADITAFKATTVPVGDDQEPMLEQ
TREIVRSFNKTYQTDTLVEPEGYFPPKGLGRIPGLDGNAKMSKSLGNAIYLSDDADTLKKKVMSMYTDPDHIHIEDPGKV
EGNVVFTYLDIFDEDKAKVADLKAAYQHGGLGDVKIKRYLMDVLDGVLRPIRERRAIYEADPAQVLQILKDGTAKANVVA
DQTWREMQDAIGINYFE

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=344, Percent_Identity=30.2325581395349, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI41352700, Length=174, Percent_Identity=38.5057471264368, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1789786, Length=348, Percent_Identity=34.1954022988506, Blast_Score=167, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71982800, Length=341, Percent_Identity=28.1524926686217, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71982793, Length=348, Percent_Identity=28.735632183908, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320474, Length=237, Percent_Identity=34.1772151898734, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24666151, Length=335, Percent_Identity=31.044776119403, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI17864462, Length=306, Percent_Identity=25.8169934640523, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24645295, Length=306, Percent_Identity=25.8169934640523, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37614; Mature: 37483

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKVILTGDRPTGKLHIGHYVGSLRNRVALQDSGDYDSYIMIADNQALTDNAHDPEKIR
CCCEEEEECCCCCCEEEHHHHHHHHHHCEEECCCCCCCCEEEEECCCCCCCCCCCHHHHH
KSLLQVAMDYLAVGIDPQKSTILVQSQIPALTDMMNQYLNLVTVARLNRNPTVKTEIKQK
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AFGESVPAGFFVYPVSQAADITAFKATTVPVGDDQEPMLEQTREIVRSFNKTYQTDTLVE
HCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEC
PEGYFPPKGLGRIPGLDGNAKMSKSLGNAIYLSDDADTLKKKVMSMYTDPDHIHIEDPGK
CCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCCCC
VEGNVVFTYLDIFDEDKAKVADLKAAYQHGGLGDVKIKRYLMDVLDGVLRPIRERRAIYE
CCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADPAQVLQILKDGTAKANVVADQTWREMQDAIGINYFE
CCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKKVILTGDRPTGKLHIGHYVGSLRNRVALQDSGDYDSYIMIADNQALTDNAHDPEKIR
CCEEEEECCCCCCEEEHHHHHHHHHHCEEECCCCCCCCEEEEECCCCCCCCCCCHHHHH
KSLLQVAMDYLAVGIDPQKSTILVQSQIPALTDMMNQYLNLVTVARLNRNPTVKTEIKQK
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AFGESVPAGFFVYPVSQAADITAFKATTVPVGDDQEPMLEQTREIVRSFNKTYQTDTLVE
HCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEC
PEGYFPPKGLGRIPGLDGNAKMSKSLGNAIYLSDDADTLKKKVMSMYTDPDHIHIEDPGK
CCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCCCC
VEGNVVFTYLDIFDEDKAKVADLKAAYQHGGLGDVKIKRYLMDVLDGVLRPIRERRAIYE
CCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADPAQVLQILKDGTAKANVVADQTWREMQDAIGINYFE
CCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]