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The map label for this gene is frlR [H]

Identifier: 28377172

GI number: 28377172

Start: 220941

End: 221636

Strand: Direct

Name: frlR [H]

Synonym: lp_0245

Alternate gene names: 28377172

Gene position: 220941-221636 (Clockwise)

Preceding gene: 28377171

Following gene: 28377173

Centisome position: 6.68

GC content: 43.82

Gene sequence:

>696_bases
ATGGAAACAAAAATTCTATATCAAAAAGTTTCCGCAGATCTTAAACGACGGATTCTAGATGGTGACTATGAAGTAGGCGG
CTTAATTCCAAGTGAAGGGGAACTTGAACGTTACTATCAAGTCAGCAAGATTACCATTCGCAAGGCGGTCGAAGTTTTGG
TCAGTGAGGGCTACTTGGAGAAGAAGAGTGGTATTGGCACGCGCGTTATTAGTAACGATCTATTTAACAAGTTGACGCAG
ACGCAGTCGTTTACGGCAACGGTCGGCCAGCAAGGAAAGTTGACCAAAGAGTTGATCAAAATTGAACGCGTGCCAGCTGT
CCCTGCATTGCTACCCAGCGAGTCTCAAGGGACGATGTTACGTATTAAGCGCCGTTATTTATTAGATGGAAAACCATTTG
CGGTTGTCGATCATTATTTACCGAATACTTTGGTTCCTACTAAACTAACGGCCCTTCGGCATCGTTCACTGTATAAGATT
TTACAGGAGAATGGTCAGACGATTACACATTTTCAAGATAAATTCAGTGCTGTCACCCTGGCGGATAGTGAGCGGGCGTT
GCTTGAAAGTCAAACGCCATTAGCGATTCGGCGCGAACGTAAGGGGTATGATGGTCACCAGCGGCTAGTTGAATTTTCTA
TTGCGACTTATCAAACGGATGTTGTCCCGTATCAAATAAATTATGACGTTTTATAA

Upstream 100 bases:

>100_bases
GCTTAATAAACCGATTTTGACAGTTTTGTAATCTGGTGTTTTAGATCGAAATGTAATAGAGTTATATTAATAATTTATGT
ACGTGAAAGGTAACGATAGC

Downstream 100 bases:

>100_bases
ATTGAACCGATACGCGGTCTGATATGCGCTGATGCACTGTGGTGGTCAGCGCATTTTTATCAGGTCGGAAGTTCAGGCGG
ATGCTATGCAGATAACAGTT

Product: transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
METKILYQKVSADLKRRILDGDYEVGGLIPSEGELERYYQVSKITIRKAVEVLVSEGYLEKKSGIGTRVISNDLFNKLTQ
TQSFTATVGQQGKLTKELIKIERVPAVPALLPSESQGTMLRIKRRYLLDGKPFAVVDHYLPNTLVPTKLTALRHRSLYKI
LQENGQTITHFQDKFSAVTLADSERALLESQTPLAIRRERKGYDGHQRLVEFSIATYQTDVVPYQINYDVL

Sequences:

>Translated_231_residues
METKILYQKVSADLKRRILDGDYEVGGLIPSEGELERYYQVSKITIRKAVEVLVSEGYLEKKSGIGTRVISNDLFNKLTQ
TQSFTATVGQQGKLTKELIKIERVPAVPALLPSESQGTMLRIKRRYLLDGKPFAVVDHYLPNTLVPTKLTALRHRSLYKI
LQENGQTITHFQDKFSAVTLADSERALLESQTPLAIRRERKGYDGHQRLVEFSIATYQTDVVPYQINYDVL
>Mature_231_residues
METKILYQKVSADLKRRILDGDYEVGGLIPSEGELERYYQVSKITIRKAVEVLVSEGYLEKKSGIGTRVISNDLFNKLTQ
TQSFTATVGQQGKLTKELIKIERVPAVPALLPSESQGTMLRIKRRYLLDGKPFAVVDHYLPNTLVPTKLTALRHRSLYKI
LQENGQTITHFQDKFSAVTLADSERALLESQTPLAIRRERKGYDGHQRLVEFSIATYQTDVVPYQINYDVL

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=185, Percent_Identity=33.5135135135135, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790118, Length=150, Percent_Identity=28, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790540, Length=233, Percent_Identity=26.1802575107296, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786950, Length=226, Percent_Identity=25.6637168141593, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788418, Length=224, Percent_Identity=26.3392857142857, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26260; Mature: 26260

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKILYQKVSADLKRRILDGDYEVGGLIPSEGELERYYQVSKITIRKAVEVLVSEGYLE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
KKSGIGTRVISNDLFNKLTQTQSFTATVGQQGKLTKELIKIERVPAVPALLPSESQGTML
HHCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHE
RIKRRYLLDGKPFAVVDHYLPNTLVPTKLTALRHRSLYKILQENGQTITHFQDKFSAVTL
EEEHHHHCCCCCCEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCEEEE
ADSERALLESQTPLAIRRERKGYDGHQRLVEFSIATYQTDVVPYQINYDVL
CCCHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHEEECCEEEEEECCCC
>Mature Secondary Structure
METKILYQKVSADLKRRILDGDYEVGGLIPSEGELERYYQVSKITIRKAVEVLVSEGYLE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
KKSGIGTRVISNDLFNKLTQTQSFTATVGQQGKLTKELIKIERVPAVPALLPSESQGTML
HHCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHE
RIKRRYLLDGKPFAVVDHYLPNTLVPTKLTALRHRSLYKILQENGQTITHFQDKFSAVTL
EEEHHHHCCCCCCEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCEEEE
ADSERALLESQTPLAIRRERKGYDGHQRLVEFSIATYQTDVVPYQINYDVL
CCCHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHEEECCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]