| Definition | Lactobacillus plantarum WCFS1, complete genome. |
|---|---|
| Accession | NC_004567 |
| Length | 3,308,274 |
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The map label for this gene is dkgB [H]
Identifier: 28377154
GI number: 28377154
Start: 203381
End: 204211
Strand: Direct
Name: dkgB [H]
Synonym: lp_0221
Alternate gene names: 28377154
Gene position: 203381-204211 (Clockwise)
Preceding gene: 28377153
Following gene: 28377158
Centisome position: 6.15
GC content: 42.96
Gene sequence:
>831_bases TTGGAAACTTATACGTTACGTGATGGTTTAACAGTACCTAAAATTGGCTTTGGAACATATAAACTGAATGGTGCTCATGG TGTGCAAGTGATCGACTCAGCGATTGATCGCGGCTACCGATTATTAGATACGGCCTTTAACTATGAAAATGAAGGTGCTG TTGGTAAAGCGGTTCGGCGTTCGTCAGTACCGCGTTCGGAACTCTTGATTTCATCAAAACTTCCTGGTCGCCACCACACC TACACGGAAGCTATCAATACGATTCAAGAATCATTATATCGAGCTGGCCTGGATTATTATGATTTATATCTAATTCATTG GCCTAACCCTAAGGAAGATCATTATGTTGAAGCTTGGCAGGCACTGATTAATGCCCAGAAGTTAGGCTTGATTCGTTCGA TTGGGGTCTCAAATTTCTTACCAGAACATTTAGAACGATTAAACAAAGAAACGGGTGTTTTACCCGTCATTAATCAGGTC GAATTACATCCGTACTTTAACCAGCAGGCACAACGGGATTATGATCAAGCACACGGTATTTTGACGCAAGATTGGAGTCC CCTTGGCCGGGCCAGTGAGATGCTTCAAAATGAGACGCTCAAAGAGATTGCAGTGCACTACCATAAAAATGTTGGTCAGT TGATTTTACGGTGGGAACTACAGTTAGGGACCTTGCCGATTCCAAAGTCGTCAACGCCGAGCCGTCAAGCAGGTAATATG GACGTGTTTGATTTTGAAATCAGTGCAGCTGATATGGCAACAATTAATGGTTTGAGCCAAGTGGATGGTCGCTTGAATAA TCAAGATCCAGCAGTGTACCAAGAGTTTTAA
Upstream 100 bases:
>100_bases CATTTGAAGCAGCGATTCGTGATGCCTTGGCTGATCGTTCAGAAGATTAACGATAAATTTAACAATGATCGTTTAATTTA AAAGAAAGAAGTGGCTTAAG
Downstream 100 bases:
>100_bases TTTGAATGATATAAAAAGATAGCGACGTTGTGATGATAACTCGTCGCTATCTTTTTATGGGCAACTGCTTGTTGATGATT GGTTTGTGATATCAGCGTAA
Product: oxidoreductase
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 276; Mature: 276
Protein sequence:
>276_residues METYTLRDGLTVPKIGFGTYKLNGAHGVQVIDSAIDRGYRLLDTAFNYENEGAVGKAVRRSSVPRSELLISSKLPGRHHT YTEAINTIQESLYRAGLDYYDLYLIHWPNPKEDHYVEAWQALINAQKLGLIRSIGVSNFLPEHLERLNKETGVLPVINQV ELHPYFNQQAQRDYDQAHGILTQDWSPLGRASEMLQNETLKEIAVHYHKNVGQLILRWELQLGTLPIPKSSTPSRQAGNM DVFDFEISAADMATINGLSQVDGRLNNQDPAVYQEF
Sequences:
>Translated_276_residues METYTLRDGLTVPKIGFGTYKLNGAHGVQVIDSAIDRGYRLLDTAFNYENEGAVGKAVRRSSVPRSELLISSKLPGRHHT YTEAINTIQESLYRAGLDYYDLYLIHWPNPKEDHYVEAWQALINAQKLGLIRSIGVSNFLPEHLERLNKETGVLPVINQV ELHPYFNQQAQRDYDQAHGILTQDWSPLGRASEMLQNETLKEIAVHYHKNVGQLILRWELQLGTLPIPKSSTPSRQAGNM DVFDFEISAADMATINGLSQVDGRLNNQDPAVYQEF >Mature_276_residues METYTLRDGLTVPKIGFGTYKLNGAHGVQVIDSAIDRGYRLLDTAFNYENEGAVGKAVRRSSVPRSELLISSKLPGRHHT YTEAINTIQESLYRAGLDYYDLYLIHWPNPKEDHYVEAWQALINAQKLGLIRSIGVSNFLPEHLERLNKETGVLPVINQV ELHPYFNQQAQRDYDQAHGILTQDWSPLGRASEMLQNETLKEIAVHYHKNVGQLILRWELQLGTLPIPKSSTPSRQAGNM DVFDFEISAADMATINGLSQVDGRLNNQDPAVYQEF
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 25DKGR-B has higher catalytic efficiency than 25DKGR-A [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=33.9100346020761, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI24497577, Length=287, Percent_Identity=32.404181184669, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI5174391, Length=287, Percent_Identity=32.404181184669, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI93277124, Length=295, Percent_Identity=30.5084745762712, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI4502049, Length=283, Percent_Identity=34.6289752650177, Blast_Score=148, Evalue=6e-36, Organism=Homo sapiens, GI24497583, Length=296, Percent_Identity=32.4324324324324, Blast_Score=144, Evalue=9e-35, Organism=Homo sapiens, GI291291012, Length=260, Percent_Identity=33.8461538461538, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=32.6530612244898, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI5453543, Length=296, Percent_Identity=31.7567567567568, Blast_Score=142, Evalue=4e-34, Organism=Homo sapiens, GI310109920, Length=296, Percent_Identity=31.7567567567568, Blast_Score=141, Evalue=7e-34, Organism=Homo sapiens, GI45446745, Length=296, Percent_Identity=31.4189189189189, Blast_Score=140, Evalue=1e-33, Organism=Homo sapiens, GI4503285, Length=296, Percent_Identity=31.4189189189189, Blast_Score=140, Evalue=1e-33, Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=32.7338129496403, Blast_Score=139, Evalue=2e-33, Organism=Homo sapiens, GI24497585, Length=292, Percent_Identity=31.1643835616438, Blast_Score=135, Evalue=5e-32, Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=32.9710144927536, Blast_Score=130, Evalue=2e-30, Organism=Homo sapiens, GI300116271, Length=277, Percent_Identity=29.2418772563177, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI310109924, Length=144, Percent_Identity=34.0277777777778, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI310109926, Length=127, Percent_Identity=35.4330708661417, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI207028673, Length=127, Percent_Identity=34.6456692913386, Blast_Score=69, Evalue=5e-12, Organism=Escherichia coli, GI87082198, Length=266, Percent_Identity=43.2330827067669, Blast_Score=222, Evalue=2e-59, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=33.7254901960784, Blast_Score=147, Evalue=7e-37, Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=29.4776119402985, Blast_Score=83, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71998625, Length=270, Percent_Identity=38.1481481481481, Blast_Score=169, Evalue=1e-42, Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=34.5890410958904, Blast_Score=161, Evalue=3e-40, Organism=Caenorhabditis elegans, GI17537075, Length=292, Percent_Identity=34.5890410958904, Blast_Score=157, Evalue=4e-39, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=34.5588235294118, Blast_Score=151, Evalue=4e-37, Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=32.5925925925926, Blast_Score=150, Evalue=7e-37, Organism=Caenorhabditis elegans, GI17564128, Length=313, Percent_Identity=30.6709265175719, Blast_Score=145, Evalue=2e-35, Organism=Caenorhabditis elegans, GI17537079, Length=303, Percent_Identity=30.6930693069307, Blast_Score=141, Evalue=4e-34, Organism=Caenorhabditis elegans, GI17552492, Length=264, Percent_Identity=32.5757575757576, Blast_Score=140, Evalue=8e-34, Organism=Caenorhabditis elegans, GI17566692, Length=281, Percent_Identity=30.6049822064057, Blast_Score=137, Evalue=5e-33, Organism=Caenorhabditis elegans, GI17561300, Length=258, Percent_Identity=34.1085271317829, Blast_Score=137, Evalue=8e-33, Organism=Caenorhabditis elegans, GI17550248, Length=295, Percent_Identity=31.864406779661, Blast_Score=131, Evalue=4e-31, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=27.8985507246377, Blast_Score=114, Evalue=7e-26, Organism=Saccharomyces cerevisiae, GI6320576, Length=292, Percent_Identity=32.8767123287671, Blast_Score=157, Evalue=2e-39, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=32.824427480916, Blast_Score=151, Evalue=1e-37, Organism=Saccharomyces cerevisiae, GI6324694, Length=288, Percent_Identity=31.9444444444444, Blast_Score=150, Evalue=2e-37, Organism=Saccharomyces cerevisiae, GI6321896, Length=302, Percent_Identity=29.8013245033113, Blast_Score=128, Evalue=1e-30, Organism=Saccharomyces cerevisiae, GI6319625, Length=278, Percent_Identity=32.3741007194245, Blast_Score=127, Evalue=2e-30, Organism=Saccharomyces cerevisiae, GI6320079, Length=280, Percent_Identity=30.3571428571429, Blast_Score=116, Evalue=5e-27, Organism=Drosophila melanogaster, GI24657054, Length=279, Percent_Identity=36.2007168458781, Blast_Score=174, Evalue=7e-44, Organism=Drosophila melanogaster, GI20129731, Length=276, Percent_Identity=36.231884057971, Blast_Score=172, Evalue=3e-43, Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=35.7894736842105, Blast_Score=171, Evalue=4e-43, Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=33.8983050847458, Blast_Score=160, Evalue=1e-39, Organism=Drosophila melanogaster, GI21356425, Length=280, Percent_Identity=32.8571428571429, Blast_Score=159, Evalue=3e-39, Organism=Drosophila melanogaster, GI221378297, Length=315, Percent_Identity=31.7460317460317, Blast_Score=152, Evalue=3e-37, Organism=Drosophila melanogaster, GI24662789, Length=296, Percent_Identity=31.4189189189189, Blast_Score=140, Evalue=9e-34, Organism=Drosophila melanogaster, GI45553081, Length=286, Percent_Identity=30.4195804195804, Blast_Score=137, Evalue=9e-33, Organism=Drosophila melanogaster, GI24662785, Length=289, Percent_Identity=33.2179930795848, Blast_Score=130, Evalue=8e-31, Organism=Drosophila melanogaster, GI24662781, Length=291, Percent_Identity=32.9896907216495, Blast_Score=128, Evalue=4e-30, Organism=Drosophila melanogaster, GI281366140, Length=251, Percent_Identity=30.6772908366534, Blast_Score=118, Evalue=4e-27,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 31234; Mature: 31234
Theoretical pI: Translated: 5.99; Mature: 5.99
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.4 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 1.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure METYTLRDGLTVPKIGFGTYKLNGAHGVQVIDSAIDRGYRLLDTAFNYENEGAVGKAVRR CCCEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHH SSVPRSELLISSKLPGRHHTYTEAINTIQESLYRAGLDYYDLYLIHWPNPKEDHYVEAWQ HCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHH ALINAQKLGLIRSIGVSNFLPEHLERLNKETGVLPVINQVELHPYFNQQAQRDYDQAHGI HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHCCC LTQDWSPLGRASEMLQNETLKEIAVHYHKNVGQLILRWELQLGTLPIPKSSTPSRQAGNM CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEEEECCCCCCCCCCCCCCCCCC DVFDFEISAADMATINGLSQVDGRLNNQDPAVYQEF CEEEEEECHHHHHHHCCHHHHCCCCCCCCCCCCCCC >Mature Secondary Structure METYTLRDGLTVPKIGFGTYKLNGAHGVQVIDSAIDRGYRLLDTAFNYENEGAVGKAVRR CCCEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHH SSVPRSELLISSKLPGRHHTYTEAINTIQESLYRAGLDYYDLYLIHWPNPKEDHYVEAWQ HCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHH ALINAQKLGLIRSIGVSNFLPEHLERLNKETGVLPVINQVELHPYFNQQAQRDYDQAHGI HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHCCC LTQDWSPLGRASEMLQNETLKEIAVHYHKNVGQLILRWELQLGTLPIPKSSTPSRQAGNM CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEEEECCCCCCCCCCCCCCCCCC DVFDFEISAADMATINGLSQVDGRLNNQDPAVYQEF CEEEEEECHHHHHHHCCHHHHCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA