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The map label for this gene is gnp

Identifier: 28377158

GI number: 28377158

Start: 206280

End: 206993

Strand: Direct

Name: gnp

Synonym: lp_0226

Alternate gene names: 28377158

Gene position: 206280-206993 (Clockwise)

Preceding gene: 28377154

Following gene: 28377160

Centisome position: 6.24

GC content: 42.3

Gene sequence:

>714_bases
ATGAAAGTTATCGTAGTAAAGGATCAAGCTGCCGGCGGAAAAGAAGGTTTCAAAGTATTTAAGAATGCTTTAGACAATGG
TGCGAAAGTATTTGGGTTGGCAACTGGTTCGACACCCGTTACAACTTACAAAGAAATCGTTAATAGTGACTTAGATTTCA
GTGACTGCACATCCGTTAACTTGGATGAATACGTTGGGATTGCACCAGACAACGACCAAAGTTATAAATACTTCATGCAA
ACTCATTTATTCAATGACAAGCCATTTAAGGAATCATTCTTGCCAAACGGTTTAGCTTCAGATCCAGAAGCTGAAGTTAA
GCGTTACGACAAAGTGATTGACGAACACCCAATTGACTTACAAATCTTAGGGATTGGCCGTAATGGTCACATTGGTTTTA
ACGAACCAGGTACTCCTCGCGATATTACGACGCACGTGGTTGATTTAACTGAATCAACGATTGAAGCTAACGCGCGGTTC
TTCGCCAGCGAAAATGATGTTCCTAAGCAAGCCTTCTCAATGGGCTTAGCTTCCATCATGAAGAGCAAGCACTTATTGCT
CGAAGCATTCGGCGAAAACAAGGCTGATGCGGTCAAGGGTATGATTGAAGGCCCAGATACCCCTGAATTACCAGCAAGTA
TCTTGCAAAACCATCCAGACGTTACCGTTATCATTGACGAAGCGGCTGCTAGCAAGTTAAGCAAGAAGTATTAA

Upstream 100 bases:

>100_bases
GCAAAAAATAAAAGTGAAATATTTCAGACAAACCTCTTGAATTTTAGTCTAGACCAATATACAATTGGACTATACCAAAC
AAAGAGGGAGTCAGTTAATT

Downstream 100 bases:

>100_bases
TTTTAATTAAGTTAAAAATGAACTGAAAGCCGTGCTTCATAACGATTGCGTTGTGAAGCACGGCTTTTTAATAAGTACTC
ATGTAAAGTAAAAAATGATT

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKVIVVKDQAAGGKEGFKVFKNALDNGAKVFGLATGSTPVTTYKEIVNSDLDFSDCTSVNLDEYVGIAPDNDQSYKYFMQ
THLFNDKPFKESFLPNGLASDPEAEVKRYDKVIDEHPIDLQILGIGRNGHIGFNEPGTPRDITTHVVDLTESTIEANARF
FASENDVPKQAFSMGLASIMKSKHLLLEAFGENKADAVKGMIEGPDTPELPASILQNHPDVTVIIDEAAASKLSKKY

Sequences:

>Translated_237_residues
MKVIVVKDQAAGGKEGFKVFKNALDNGAKVFGLATGSTPVTTYKEIVNSDLDFSDCTSVNLDEYVGIAPDNDQSYKYFMQ
THLFNDKPFKESFLPNGLASDPEAEVKRYDKVIDEHPIDLQILGIGRNGHIGFNEPGTPRDITTHVVDLTESTIEANARF
FASENDVPKQAFSMGLASIMKSKHLLLEAFGENKADAVKGMIEGPDTPELPASILQNHPDVTVIIDEAAASKLSKKY
>Mature_237_residues
MKVIVVKDQAAGGKEGFKVFKNALDNGAKVFGLATGSTPVTTYKEIVNSDLDFSDCTSVNLDEYVGIAPDNDQSYKYFMQ
THLFNDKPFKESFLPNGLASDPEAEVKRYDKVIDEHPIDLQILGIGRNGHIGFNEPGTPRDITTHVVDLTESTIEANARF
FASENDVPKQAFSMGLASIMKSKHLLLEAFGENKADAVKGMIEGPDTPELPASILQNHPDVTVIIDEAAASKLSKKY

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=250, Percent_Identity=33.2, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI19923881, Length=214, Percent_Identity=33.6448598130841, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1786893, Length=215, Percent_Identity=35.3488372093023, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789530, Length=203, Percent_Identity=29.064039408867, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI48994958, Length=239, Percent_Identity=27.6150627615063, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554876, Length=223, Percent_Identity=35.8744394618834, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581960, Length=215, Percent_Identity=38.1395348837209, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI19920764, Length=215, Percent_Identity=38.1395348837209, Blast_Score=134, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_LACPL (Q88ZS6)

Other databases:

- EMBL:   AL935252
- RefSeq:   NP_784050.1
- ProteinModelPortal:   Q88ZS6
- SMR:   Q88ZS6
- GeneID:   1061399
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0226
- NMPDR:   fig|220668.1.peg.184
- HOGENOM:   HBG725991
- OMA:   NRIIQFR
- ProtClustDB:   CLSK2304935
- BioCyc:   LPLA220668:LP_0226-MONOMER
- BRENDA:   3.5.99.6
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 25881; Mature: 25881

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 62-62 ACT_SITE 128-128 ACT_SITE 130-130 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIVVKDQAAGGKEGFKVFKNALDNGAKVFGLATGSTPVTTYKEIVNSDLDFSDCTSVN
CEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCC
LDEYVGIAPDNDQSYKYFMQTHLFNDKPFKESFLPNGLASDPEAEVKRYDKVIDEHPIDL
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCE
QILGIGRNGHIGFNEPGTPRDITTHVVDLTESTIEANARFFASENDVPKQAFSMGLASIM
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
KSKHLLLEAFGENKADAVKGMIEGPDTPELPASILQNHPDVTVIIDEAAASKLSKKY
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHCCC
>Mature Secondary Structure
MKVIVVKDQAAGGKEGFKVFKNALDNGAKVFGLATGSTPVTTYKEIVNSDLDFSDCTSVN
CEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCC
LDEYVGIAPDNDQSYKYFMQTHLFNDKPFKESFLPNGLASDPEAEVKRYDKVIDEHPIDL
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCE
QILGIGRNGHIGFNEPGTPRDITTHVVDLTESTIEANARFFASENDVPKQAFSMGLASIM
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
KSKHLLLEAFGENKADAVKGMIEGPDTPELPASILQNHPDVTVIIDEAAASKLSKKY
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566