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The map label for this gene is malR [H]

Identifier: 28377112

GI number: 28377112

Start: 147271

End: 148290

Strand: Direct

Name: malR [H]

Synonym: lp_0172

Alternate gene names: 28377112

Gene position: 147271-148290 (Clockwise)

Preceding gene: 28377111

Following gene: 28377113

Centisome position: 4.45

GC content: 41.96

Gene sequence:

>1020_bases
ATGGCAACGATCAAAGATGTTGCCCAGCGCGCAGGTGTTTCGCCTTCAACAGCGTCACGTGCAATGCATGGTAGCAAGAT
TATCAGTAAGCCAACACGTGACAAGGTCATTAAAGCGGCGCGGGAGTTAAATTACGCGCCGGATTTTAATGCGCAGAATT
TAGCAACTAAGGCTAGTAATACAATCGGGGTGGTACTACCAGTAGATCATCACGAAATCTTTTCTAACCCATTTTTCTTA
GAGATGATTCGGGGTATCAATGAAGTTTGTAGTAAGAATGGCGCAATGACAACGCTAGCAACGGGGATTTCAAGTGATGA
ACTGGTGCATAATATTGATGTCATGATTGCACAAGGCCATATCAAAACTTTTATTTTACTGTATTCTGAAAAAAATGACC
CAGTTGTTGAGCGCTTGAAGCAATTTGATGTCCAATACGTTGTGATTGGTAAACCTTACCAAGACGTCAATAAAACATCG
TATGTTGATAATGATAATATCCAAGCCGGAACGGATGCAGCCCAATATCTAATTGATCATGGACACCGGCGCATTGGGTT
TTTGTATTCGGATTTATCACGGATGGTGCAAAGTGATCGGATGCTTGGCTATCAACGTGTAATGATGCAAAATCAGTTAC
CAAATATTATGTTGGAAGAACGGTTTGAGACTCATGCGGCGGGTGTTAAAACACTACATAAGTTTTTTGAACAGTATCCA
GATGTTACCGGGTTTGTGGCCGTAGATGATATGTTGGCGTTGAAATTACAACAGGTTCTCCATAATGATCCGAACTGGAA
AGTTAAACAATTCTCACTGATTGGTTTTAATAACTCCATTTTTTCTGATTTAGCGCACCCGATGCTGACATCGATTGCGG
TCTTTCCACAGCGTTTAGGTGAAGAAGCGGCCAAGATTGCGATGGCTGACCATCCTGCTGATGAATTATCAACGGCAGTA
ATTGTGCCTCATCAAATTGTTAAACGCCATTCCGTCCACCAAATCAAGTCCTTACAGTAG

Upstream 100 bases:

>100_bases
ATAATTAAATAAATAATGCAAGTTTATGCAATCGCTTGCAATAACGATGAAAACGTTTTATATTTAATGAGATGGATTCA
AATAGATCGGGGGGATCATG

Downstream 100 bases:

>100_bases
TAAGTTAGGGGGGTATTTTGATTATGATAACGCTAAACGATGTCGCGAAAAAAGCTAATGTCTCAAAAATGACAGTTTCA
CGAGTCATTAATCATCCGGA

Product: transcription regulator

Products: NA

Alternate protein names: Maltose operon transcriptional repressor [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MATIKDVAQRAGVSPSTASRAMHGSKIISKPTRDKVIKAARELNYAPDFNAQNLATKASNTIGVVLPVDHHEIFSNPFFL
EMIRGINEVCSKNGAMTTLATGISSDELVHNIDVMIAQGHIKTFILLYSEKNDPVVERLKQFDVQYVVIGKPYQDVNKTS
YVDNDNIQAGTDAAQYLIDHGHRRIGFLYSDLSRMVQSDRMLGYQRVMMQNQLPNIMLEERFETHAAGVKTLHKFFEQYP
DVTGFVAVDDMLALKLQQVLHNDPNWKVKQFSLIGFNNSIFSDLAHPMLTSIAVFPQRLGEEAAKIAMADHPADELSTAV
IVPHQIVKRHSVHQIKSLQ

Sequences:

>Translated_339_residues
MATIKDVAQRAGVSPSTASRAMHGSKIISKPTRDKVIKAARELNYAPDFNAQNLATKASNTIGVVLPVDHHEIFSNPFFL
EMIRGINEVCSKNGAMTTLATGISSDELVHNIDVMIAQGHIKTFILLYSEKNDPVVERLKQFDVQYVVIGKPYQDVNKTS
YVDNDNIQAGTDAAQYLIDHGHRRIGFLYSDLSRMVQSDRMLGYQRVMMQNQLPNIMLEERFETHAAGVKTLHKFFEQYP
DVTGFVAVDDMLALKLQQVLHNDPNWKVKQFSLIGFNNSIFSDLAHPMLTSIAVFPQRLGEEAAKIAMADHPADELSTAV
IVPHQIVKRHSVHQIKSLQ
>Mature_338_residues
ATIKDVAQRAGVSPSTASRAMHGSKIISKPTRDKVIKAARELNYAPDFNAQNLATKASNTIGVVLPVDHHEIFSNPFFLE
MIRGINEVCSKNGAMTTLATGISSDELVHNIDVMIAQGHIKTFILLYSEKNDPVVERLKQFDVQYVVIGKPYQDVNKTSY
VDNDNIQAGTDAAQYLIDHGHRRIGFLYSDLSRMVQSDRMLGYQRVMMQNQLPNIMLEERFETHAAGVKTLHKFFEQYPD
VTGFVAVDDMLALKLQQVLHNDPNWKVKQFSLIGFNNSIFSDLAHPMLTSIAVFPQRLGEEAAKIAMADHPADELSTAVI
VPHQIVKRHSVHQIKSLQ

Specific function: Transcriptional repressor of the maltosaccharide utilization operons malxCD and malMP [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787580, Length=309, Percent_Identity=27.5080906148867, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787948, Length=308, Percent_Identity=26.2987012987013, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790369, Length=310, Percent_Identity=29.3548387096774, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790194, Length=313, Percent_Identity=25.8785942492013, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789068, Length=304, Percent_Identity=25.9868421052632, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788474, Length=347, Percent_Identity=27.0893371757925, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789202, Length=297, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI48994940, Length=323, Percent_Identity=25.6965944272446, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787906, Length=255, Percent_Identity=24.3137254901961, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=23.5820895522388, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790715, Length=323, Percent_Identity=26.625386996904, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37966; Mature: 37835

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVAQRAGVSPSTASRAMHGSKIISKPTRDKVIKAARELNYAPDFNAQNLATKASN
CCCHHHHHHHCCCCCCHHHHHHHCHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
TIGVVLPVDHHEIFSNPFFLEMIRGINEVCSKNGAMTTLATGISSDELVHNIDVMIAQGH
CEEEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHEEEEECCC
IKTFILLYSEKNDPVVERLKQFDVQYVVIGKPYQDVNKTSYVDNDNIQAGTDAAQYLIDH
EEEEEEEEECCCCHHHHHHHHCCCEEEEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHHC
GHRRIGFLYSDLSRMVQSDRMLGYQRVMMQNQLPNIMLEERFETHAAGVKTLHKFFEQYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DVTGFVAVDDMLALKLQQVLHNDPNWKVKQFSLIGFNNSIFSDLAHPMLTSIAVFPQRLG
CCCEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
EEAAKIAMADHPADELSTAVIVPHQIVKRHSVHQIKSLQ
HHHHHHHHCCCCHHHHHHEEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATIKDVAQRAGVSPSTASRAMHGSKIISKPTRDKVIKAARELNYAPDFNAQNLATKASN
CCHHHHHHHCCCCCCHHHHHHHCHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCC
TIGVVLPVDHHEIFSNPFFLEMIRGINEVCSKNGAMTTLATGISSDELVHNIDVMIAQGH
CEEEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHEEEEECCC
IKTFILLYSEKNDPVVERLKQFDVQYVVIGKPYQDVNKTSYVDNDNIQAGTDAAQYLIDH
EEEEEEEEECCCCHHHHHHHHCCCEEEEEECCHHHCCCCCCCCCCCCCCCHHHHHHHHHC
GHRRIGFLYSDLSRMVQSDRMLGYQRVMMQNQLPNIMLEERFETHAAGVKTLHKFFEQYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DVTGFVAVDDMLALKLQQVLHNDPNWKVKQFSLIGFNNSIFSDLAHPMLTSIAVFPQRLG
CCCEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
EEAAKIAMADHPADELSTAVIVPHQIVKRHSVHQIKSLQ
HHHHHHHHCCCCHHHHHHEEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]