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The map label for this gene is mdtG [H]

Identifier: 28377080

GI number: 28377080

Start: 116619

End: 117851

Strand: Direct

Name: mdtG [H]

Synonym: lp_0132

Alternate gene names: 28377080

Gene position: 116619-117851 (Clockwise)

Preceding gene: 28377077

Following gene: 28377081

Centisome position: 3.53

GC content: 45.17

Gene sequence:

>1233_bases
GTGGATGACGCAGAACGTGAACGCGGACCATGGCATCGTAATTTGATTGTTTTATGGTTTTGTACGTTCGTTGCGGGAAT
GGCATTTAGCGAAATTATGCCATTTCTTTCATTATTTGTTAGTCAGCTGGGTGATTTCACGAAGGCCCAGATTACATTTT
ATAGCGGGTTAGCTTTTGCAGCTGATTACGCGATTTCAGCAATTTCGGCACCACTGTGGGGCATCATTGCTGATAAAAAA
GGTCGTAAGATCATGCTATTGCGCGCGTCCCTAGGGATGGCAGTTGCGATGGGGTTAATGGGTTTTGTAACGAATGTCTG
GCAACTAGTTGCCTTGCGCGCGCTACAAGGTGTGTTTGCGGGCTTTATTTCTAATGCCCAAGCCTTAGTCGCGTCCCAAA
CGCCACGTAAATATAGTGGACGGGCGTTGAGCACTTTGATCACTGGTGCCGTTAGTGGTCAATTGTTTGGCCCAGTGATT
GGGGGCTTGCTAGCCCAATTGTTTTCGATTCGAAACACGTTTTTTATTACGGCCGGATTATTAATGGTGGCGTTTTTGTT
GAGTCTGTTCTTTGTACAGGAACACTTCAAACCAGTCGCACATCATCGTGAACCAGGTGACAGTCGCAATCCTTTAGCAG
CGTTTCAAAATCCGCGCTTGATTATTGTGATGTTATGTTCGACGGCCATCGTCCAATTTGGAAACGCCTCGATTGCACCA
ATCATTAGTTTATACGTTCGTGAATTGATGCATTACCGTGGCCCGATTACGGTTGTGGCCGGAATTATCGCAGCTTTACC
GGGTATTTCAAACATCTTTTCAGCACCGCGCCTTGGACGTTATGGTGATCAGCACGGTTCTGGTAAGGTATTGTTATTTG
GCTATATTTTTGCGGTGATTATGTATTTCCCACAAGGCATTGTTACGAGCGTCGTGGCCCTCGGTATTTTGCGGTTTGCC
ATTGGGATTTCCGATGGCGCACTATATCCAGAGATTCAAACGGTTTTGACTAAGAATACGCCAGTACATCTTACCTCAAC
GATTTTTAGCTATAATCAATCTTTTCAAGCTATTGGCAATATGTTCGGCGCCTTGCTCGGTGGTTTGGTGGCTGGTTGGT
TCAATTACAACGCGGTATTCATTATGACGGCGTTACTTTTGTTAATTAACCTAGGTTTAATTTTGTGGTTAGTTCCTGAT
ATTTGGAAGAACGGCAAACGGGCAGTTTCCTAG

Upstream 100 bases:

>100_bases
CGGGAAATAATTGTCACTGGTGGTCGCTAAATATGATAAGCTAATTAACGGTATAATACTTACTGAAAATTAGTGTCAAT
TAGATATGGAGATGACGAGC

Downstream 100 bases:

>100_bases
GTGTTTGGTAGTTAGTCTATTAAATTGGCTAGCTGCCTTTTTTGTTACTTGTCCTTGAACATGATGTTAATTCAGTGTAT
TGTTAGTTTCATGAATATCG

Product: transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFAADYAISAISAPLWGIIADKK
GRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFAGFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVI
GGLLAQLFSIRNTFFITAGLLMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAP
IISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVIMYFPQGIVTSVVALGILRFA
IGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGNMFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPD
IWKNGKRAVS

Sequences:

>Translated_410_residues
MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFAADYAISAISAPLWGIIADKK
GRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFAGFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVI
GGLLAQLFSIRNTFFITAGLLMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAP
IISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVIMYFPQGIVTSVVALGILRFA
IGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGNMFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPD
IWKNGKRAVS
>Mature_410_residues
MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFAADYAISAISAPLWGIIADKK
GRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFAGFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVI
GGLLAQLFSIRNTFFITAGLLMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAP
IISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVIMYFPQGIVTSVVALGILRFA
IGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGNMFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPD
IWKNGKRAVS

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=380, Percent_Identity=46.0526315789474, Blast_Score=336, Evalue=1e-93,
Organism=Escherichia coli, GI87082404, Length=306, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319871, Length=160, Percent_Identity=31.875, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44523; Mature: 44523

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADYAISAISAPLWGIIADKKGRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFA
HHHHHHHHHCCHHHEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVIGGLLAQLFSIRNTFFITAGL
HHHCCHHHHHHCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCEEEHHHHHHHHHHCCCCCHHH
IISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVI
HHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHH
MYFPQGIVTSVVALGILRFAIGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGN
HHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPDIWKNGKRAVS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADYAISAISAPLWGIIADKKGRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFA
HHHHHHHHHCCHHHEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVIGGLLAQLFSIRNTFFITAGL
HHHCCHHHHHHCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCEEEHHHHHHHHHHCCCCCHHH
IISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVI
HHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHH
MYFPQGIVTSVVALGILRFAIGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGN
HHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPDIWKNGKRAVS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA