Click here to switch to the map view.

The map label for this gene is alsR [H]

Identifier: 28377020

GI number: 28377020

Start: 57132

End: 58037

Strand: Direct

Name: alsR [H]

Synonym: lp_0057

Alternate gene names: 28377020

Gene position: 57132-58037 (Clockwise)

Preceding gene: 28377019

Following gene: 28377022

Centisome position: 1.73

GC content: 47.35

Gene sequence:

>906_bases
TTGAATGGGGGCGTTGACGTGAATGAACGCGATTTAAAGTACTTCTGTTCATTAGTTGAGACGGGAAATTACACGGCCAC
GGCGACCAAGTTTCACGTCACACAACCGGCTATTTCTGCAGCTTTACGACGATTGGAAGAAGAATACCAAGCAGTATTAC
TAACGCAGGCCAACCATCGGGCCCAACTAGTAACGACGGCAGCGGGGCGGACCTTGTATATTAAGTCTAAGCAACTCTTA
AAAGACGTTGCGCAGATGGCACTGGAAGTTCATCACGCTAATGAGCAGCAAGTTCGGCTCGGATTTTCCAATGTTGCGGG
TGGTATTTGGCTTCCCCGGGTGATAAAAAAATTTATCTCAGTTGATTTATTAGACCAGGTCACAACGACCGTTGCTGATT
CAGAACAATTGTTAGTTGACTTGCGGCAAGGCAAGTTAGACGCAGCGGTTTTTTCAACTTTGGTCCCAGAACGTGCCACG
GATTTACGGGTGAGCATCTTAGAGGAACATCAGATGCAGGTCTTGGCCAATGTCAATAGTCCATTAAGTCACTTAAAAAC
GATTCGAGCAACTGACTTACAAGGAGTGCCTATCATCGCTCGTCCTAAACACGCATTACCACGGTTAGCATTAGAACAAT
ATTGTCAGCGCGGCCACATACAGCCTAAAATCGTCTACGAGGCAGCTACCAACGCGTTAGTCGAAGGTCTAGTTGCTCAA
AACGTTGGTGTTGGGGTGGTCATTGCGGATTCCGTAGTGCTAAGTGATCAGGTTGTAGGGATTCCACTAGCTGCCCAAGA
GCAATTACACTGTTACATGCAACTGGCGGTGCGGAAGTCCTTTTTGCCTAACGCTAATCAGCAGCGGTGCATTGACGTCC
TACGTCAAATTAGACGGGCTAATTAG

Upstream 100 bases:

>100_bases
TTTTGGTAAGACTAACTGAGCAATATAGATGCGGTAAGTCGTGATTGATCCTGACCACGATTTGCCGCATCTTTCGTGTT
AAAATTAGGTATTAAATAGA

Downstream 100 bases:

>100_bases
GTCTTCAGCACTAATCCAAAAATAGCGCTCGCATTGACTTTTTCAGTCAACGCGAGCGCCGTCAAATCATTATTGAGCTA
ACATTTTTTGAGCGAATTCC

Product: transcription regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNGGVDVNERDLKYFCSLVETGNYTATATKFHVTQPAISAALRRLEEEYQAVLLTQANHRAQLVTTAAGRTLYIKSKQLL
KDVAQMALEVHHANEQQVRLGFSNVAGGIWLPRVIKKFISVDLLDQVTTTVADSEQLLVDLRQGKLDAAVFSTLVPERAT
DLRVSILEEHQMQVLANVNSPLSHLKTIRATDLQGVPIIARPKHALPRLALEQYCQRGHIQPKIVYEAATNALVEGLVAQ
NVGVGVVIADSVVLSDQVVGIPLAAQEQLHCYMQLAVRKSFLPNANQQRCIDVLRQIRRAN

Sequences:

>Translated_301_residues
MNGGVDVNERDLKYFCSLVETGNYTATATKFHVTQPAISAALRRLEEEYQAVLLTQANHRAQLVTTAAGRTLYIKSKQLL
KDVAQMALEVHHANEQQVRLGFSNVAGGIWLPRVIKKFISVDLLDQVTTTVADSEQLLVDLRQGKLDAAVFSTLVPERAT
DLRVSILEEHQMQVLANVNSPLSHLKTIRATDLQGVPIIARPKHALPRLALEQYCQRGHIQPKIVYEAATNALVEGLVAQ
NVGVGVVIADSVVLSDQVVGIPLAAQEQLHCYMQLAVRKSFLPNANQQRCIDVLRQIRRAN
>Mature_301_residues
MNGGVDVNERDLKYFCSLVETGNYTATATKFHVTQPAISAALRRLEEEYQAVLLTQANHRAQLVTTAAGRTLYIKSKQLL
KDVAQMALEVHHANEQQVRLGFSNVAGGIWLPRVIKKFISVDLLDQVTTTVADSEQLLVDLRQGKLDAAVFSTLVPERAT
DLRVSILEEHQMQVLANVNSPLSHLKTIRATDLQGVPIIARPKHALPRLALEQYCQRGHIQPKIVYEAATNALVEGLVAQ
NVGVGVVIADSVVLSDQVVGIPLAAQEQLHCYMQLAVRKSFLPNANQQRCIDVLRQIRRAN

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=274, Percent_Identity=23.3576642335766, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788887, Length=249, Percent_Identity=26.9076305220884, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790399, Length=268, Percent_Identity=24.2537313432836, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33248; Mature: 33248

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGGVDVNERDLKYFCSLVETGNYTATATKFHVTQPAISAALRRLEEEYQAVLLTQANHR
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECHHHHHHHHHHHHHHHHEEEEECCCCC
AQLVTTAAGRTLYIKSKQLLKDVAQMALEVHHANEQQVRLGFSNVAGGIWLPRVIKKFIS
EEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCHHEEECHHHHCCCCHHHHHHHHHHH
VDLLDQVTTTVADSEQLLVDLRQGKLDAAVFSTLVPERATDLRVSILEEHQMQVLANVNS
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PLSHLKTIRATDLQGVPIIARPKHALPRLALEQYCQRGHIQPKIVYEAATNALVEGLVAQ
HHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
NVGVGVVIADSVVLSDQVVGIPLAAQEQLHCYMQLAVRKSFLPNANQQRCIDVLRQIRRA
CCCCEEEEECCEEECCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
N
C
>Mature Secondary Structure
MNGGVDVNERDLKYFCSLVETGNYTATATKFHVTQPAISAALRRLEEEYQAVLLTQANHR
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECHHHHHHHHHHHHHHHHEEEEECCCCC
AQLVTTAAGRTLYIKSKQLLKDVAQMALEVHHANEQQVRLGFSNVAGGIWLPRVIKKFIS
EEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCHHEEECHHHHCCCCHHHHHHHHHHH
VDLLDQVTTTVADSEQLLVDLRQGKLDAAVFSTLVPERATDLRVSILEEHQMQVLANVNS
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PLSHLKTIRATDLQGVPIIARPKHALPRLALEQYCQRGHIQPKIVYEAATNALVEGLVAQ
HHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
NVGVGVVIADSVVLSDQVVGIPLAAQEQLHCYMQLAVRKSFLPNANQQRCIDVLRQIRRA
CCCCEEEEECCEEECCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]