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The map label for this gene is hpk1 [H]

Identifier: 28377005

GI number: 28377005

Start: 38491

End: 40365

Strand: Direct

Name: hpk1 [H]

Synonym: lp_0037

Alternate gene names: 28377005

Gene position: 38491-40365 (Clockwise)

Preceding gene: 28377004

Following gene: 28377006

Centisome position: 1.16

GC content: 43.2

Gene sequence:

>1875_bases
GTGTTGAGATTTAAACGGAAAAATTTTTTTAAAACAATTAATTTCAAAATTGCGCTCGTGTTTGCCCTTCTATTATTGAT
TACGTTGGAAATCGTGGGTGCAATCTTTGTGAAACAGTTGGAATCAAAGAACATCCAGGATTTTAAACAGTCGGTGCAAA
TTCCAACTTATATTGATAATTCGTTGTCCGAACAATTGACCGTCAGCAGTACGCGCAAGGCCAACGGCCAAATCAAGACG
ATTTTGTCGAACTACAACAATACGAATGTTGATGAAATCCAAGTTGTTGACAGCAAAGGAACAATTCGTGGGACGAGTGA
TGTTAATGATCAGTCAGTAGTTGGACAAAAAACGACCGATCGAAACGTCAAGAATGCAATCTATAATAATCGAACTTACA
CTAAAAGTACCTATGACACTCAGAATAATGGACGCTACTACGTTTCAATCGTGCCGCTATATAGCTCCAATTCAGCGGGT
AATAGCAGTCAGTTAGTTGGGGTACTGTATGTACGGGCAAATATGAAGTCTGTCTACAGTACGATTAACAACATTATGGG
AATCTTTGTGATTGCGTCACTTGCTGCGATGGTCTTGGGACTGGGAATTGCAATCATTATTGCCCGGGCAATAACTCGTC
CAATCGAAGAAATGAAGCAGCAGACGCAACGAATTGCCCGTGGTGATTATGCGGGGCAAGTCCGAGTTTATAGCGATGAT
GAGTTGGGCCAGTTGGCTAAAGCCATTAATAACTTGTCGATTCGTGTGGAAGAATCGCAAGAGTCGACAGAAGCTGAGCG
ACGCCGGTTGGATAGTGTGCTCTCACACATGAGTGATGGCGTGATTGCCACGGATCGCCGGGGTAATATAACCATCATCA
ATGAAACAGCCTCGGACTTTATGGACGTTACGGCCGAAAAGGCAATCGGTAACTCGATTTTAGATATTTTAAAAATCCGT
GATGATTATTCATTGCGTGATTTGATTGAAAATCAAGATGAATTGATGCTTGATTTTTCTTCGAACGAGCGTGACCTAAT
CTTGAATGCCTACTTCTCGTTAATTCAACGGGAGTCTGGGTTTATTAGTGGGTTAGTCTGTGTGCTCCACGATGTCACGG
AACAACAAAAGATTGATAATGACCGGAAACAATTTGTTTCGAACGTGTCTCATGAATTACGGACACCACTGACTAGTTTG
CGGAGTTATATTGAAGCACTGAGTGATGGTGCGTGGAAGGATCCTGAAGTGGCCCCAGGATTTTTGAAGGTCACTCAAGA
AGAAACTGATCGTATGATTCGAATGATCAATGAACTCTTAAGTCTATCACGGATGGACTCAGGGACCACCCGGGTCGATA
TGGAATTGGTCAATATTAACGAGATGTTCAATTACGTGCTTGATCGGTTTGATATGATCTTAAAGAAGGATGATAATCCA
GCTAAGTATTACACTATTAAGCGCGAGTTTACCAAGCGTGATCTGTGGGTTGAAATTGATACCGATAAATTCACTCAAGT
ATTGGATAACATTATGAATAATGCGATCAAGTATTCACCTGATGGTGGTGTCGTGACTTGTCGGCTGTTAGAGACGCATA
ACCAAGTGATCATTAGTATTAGTGATCAGGGCTTGGGTATCCCACGGGCCGACTTAGGACACGTCTTTGACCGATTCTTC
CGAGTCGACAAGGCGCGGTCACGGGCCCAAGGTGGGACGGGCCTCGGTTTGGCGATTTCAAAAGAAGTTGTTCAGATGCT
CGGCGGTCGTATTTGGGTTGATAGTGTTGAAGGTAAGGGGTCTACGTTCTATATCTCCTTGCCATACGAACCTTATGAGG
AGGAGGACCTTTGGGATGACGACTCACAAGCTTAG

Upstream 100 bases:

>100_bases
AAAGTTGAAGATAACCCGAGTCATCCAAAATGGCTGGTGACGCGGCGGGGCGTGGGTTACTATCTCCGCAATCCTGAAAA
TGAGTAGAGGTTGCTAAACC

Downstream 100 bases:

>100_bases
ACGCTTTATCTTACCCATTTTATTGACGATTCTGATCTTATTGAGCGTGGTTTTATCCATGTATATCTGGTTGAATCCGT
CACGCTATGAGCATGAAAGC

Product: histidine protein kinase; sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MLRFKRKNFFKTINFKIALVFALLLLITLEIVGAIFVKQLESKNIQDFKQSVQIPTYIDNSLSEQLTVSSTRKANGQIKT
ILSNYNNTNVDEIQVVDSKGTIRGTSDVNDQSVVGQKTTDRNVKNAIYNNRTYTKSTYDTQNNGRYYVSIVPLYSSNSAG
NSSQLVGVLYVRANMKSVYSTINNIMGIFVIASLAAMVLGLGIAIIIARAITRPIEEMKQQTQRIARGDYAGQVRVYSDD
ELGQLAKAINNLSIRVEESQESTEAERRRLDSVLSHMSDGVIATDRRGNITIINETASDFMDVTAEKAIGNSILDILKIR
DDYSLRDLIENQDELMLDFSSNERDLILNAYFSLIQRESGFISGLVCVLHDVTEQQKIDNDRKQFVSNVSHELRTPLTSL
RSYIEALSDGAWKDPEVAPGFLKVTQEETDRMIRMINELLSLSRMDSGTTRVDMELVNINEMFNYVLDRFDMILKKDDNP
AKYYTIKREFTKRDLWVEIDTDKFTQVLDNIMNNAIKYSPDGGVVTCRLLETHNQVIISISDQGLGIPRADLGHVFDRFF
RVDKARSRAQGGTGLGLAISKEVVQMLGGRIWVDSVEGKGSTFYISLPYEPYEEEDLWDDDSQA

Sequences:

>Translated_624_residues
MLRFKRKNFFKTINFKIALVFALLLLITLEIVGAIFVKQLESKNIQDFKQSVQIPTYIDNSLSEQLTVSSTRKANGQIKT
ILSNYNNTNVDEIQVVDSKGTIRGTSDVNDQSVVGQKTTDRNVKNAIYNNRTYTKSTYDTQNNGRYYVSIVPLYSSNSAG
NSSQLVGVLYVRANMKSVYSTINNIMGIFVIASLAAMVLGLGIAIIIARAITRPIEEMKQQTQRIARGDYAGQVRVYSDD
ELGQLAKAINNLSIRVEESQESTEAERRRLDSVLSHMSDGVIATDRRGNITIINETASDFMDVTAEKAIGNSILDILKIR
DDYSLRDLIENQDELMLDFSSNERDLILNAYFSLIQRESGFISGLVCVLHDVTEQQKIDNDRKQFVSNVSHELRTPLTSL
RSYIEALSDGAWKDPEVAPGFLKVTQEETDRMIRMINELLSLSRMDSGTTRVDMELVNINEMFNYVLDRFDMILKKDDNP
AKYYTIKREFTKRDLWVEIDTDKFTQVLDNIMNNAIKYSPDGGVVTCRLLETHNQVIISISDQGLGIPRADLGHVFDRFF
RVDKARSRAQGGTGLGLAISKEVVQMLGGRIWVDSVEGKGSTFYISLPYEPYEEEDLWDDDSQA
>Mature_624_residues
MLRFKRKNFFKTINFKIALVFALLLLITLEIVGAIFVKQLESKNIQDFKQSVQIPTYIDNSLSEQLTVSSTRKANGQIKT
ILSNYNNTNVDEIQVVDSKGTIRGTSDVNDQSVVGQKTTDRNVKNAIYNNRTYTKSTYDTQNNGRYYVSIVPLYSSNSAG
NSSQLVGVLYVRANMKSVYSTINNIMGIFVIASLAAMVLGLGIAIIIARAITRPIEEMKQQTQRIARGDYAGQVRVYSDD
ELGQLAKAINNLSIRVEESQESTEAERRRLDSVLSHMSDGVIATDRRGNITIINETASDFMDVTAEKAIGNSILDILKIR
DDYSLRDLIENQDELMLDFSSNERDLILNAYFSLIQRESGFISGLVCVLHDVTEQQKIDNDRKQFVSNVSHELRTPLTSL
RSYIEALSDGAWKDPEVAPGFLKVTQEETDRMIRMINELLSLSRMDSGTTRVDMELVNINEMFNYVLDRFDMILKKDDNP
AKYYTIKREFTKRDLWVEIDTDKFTQVLDNIMNNAIKYSPDGGVVTCRLLETHNQVIISISDQGLGIPRADLGHVFDRFF
RVDKARSRAQGGTGLGLAISKEVVQMLGGRIWVDSVEGKGSTFYISLPYEPYEEEDLWDDDSQA

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=345, Percent_Identity=29.8550724637681, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788549, Length=394, Percent_Identity=26.6497461928934, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790436, Length=227, Percent_Identity=34.8017621145374, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI145693157, Length=318, Percent_Identity=26.1006289308176, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=29.0598290598291, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788713, Length=283, Percent_Identity=26.1484098939929, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=28.6307053941909, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=28.1938325991189, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=28.8135593220339, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=270, Percent_Identity=25.1851851851852, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=27.0642201834862, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=27.8225806451613, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=25.5230125523013, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=26.2295081967213, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=26.5384615384615, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789403, Length=228, Percent_Identity=27.1929824561404, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787374, Length=225, Percent_Identity=25.7777777777778, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70500; Mature: 70500

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFKRKNFFKTINFKIALVFALLLLITLEIVGAIFVKQLESKNIQDFKQSVQIPTYIDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHCC
SLSEQLTVSSTRKANGQIKTILSNYNNTNVDEIQVVDSKGTIRGTSDVNDQSVVGQKTTD
HHHHHEECCCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHCCCCCCC
RNVKNAIYNNRTYTKSTYDTQNNGRYYVSIVPLYSSNSAGNSSQLVGVLYVRANMKSVYS
CHHHHHHHCCCCEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEEEHHHHHHHHH
TINNIMGIFVIASLAAMVLGLGIAIIIARAITRPIEEMKQQTQRIARGDYAGQVRVYSDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
ELGQLAKAINNLSIRVEESQESTEAERRRLDSVLSHMSDGVIATDRRGNITIINETASDF
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHH
MDVTAEKAIGNSILDILKIRDDYSLRDLIENQDELMLDFSSNERDLILNAYFSLIQRESG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
FISGLVCVLHDVTEQQKIDNDRKQFVSNVSHELRTPLTSLRSYIEALSDGAWKDPEVAPG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
FLKVTQEETDRMIRMINELLSLSRMDSGTTRVDMELVNINEMFNYVLDRFDMILKKDDNP
HHEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCC
AKYYTIKREFTKRDLWVEIDTDKFTQVLDNIMNNAIKYSPDGGVVTCRLLETHNQVIISI
CEEEEEEHHHCCCCEEEEECCHHHHHHHHHHHHCCEEECCCCCEEEEEEEECCCEEEEEE
SDQGLGIPRADLGHVFDRFFRVDKARSRAQGGTGLGLAISKEVVQMLGGRIWVDSVEGKG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCC
STFYISLPYEPYEEEDLWDDDSQA
CEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRFKRKNFFKTINFKIALVFALLLLITLEIVGAIFVKQLESKNIQDFKQSVQIPTYIDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHCC
SLSEQLTVSSTRKANGQIKTILSNYNNTNVDEIQVVDSKGTIRGTSDVNDQSVVGQKTTD
HHHHHEECCCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHCCCCCCC
RNVKNAIYNNRTYTKSTYDTQNNGRYYVSIVPLYSSNSAGNSSQLVGVLYVRANMKSVYS
CHHHHHHHCCCCEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEEEHHHHHHHHH
TINNIMGIFVIASLAAMVLGLGIAIIIARAITRPIEEMKQQTQRIARGDYAGQVRVYSDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
ELGQLAKAINNLSIRVEESQESTEAERRRLDSVLSHMSDGVIATDRRGNITIINETASDF
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHH
MDVTAEKAIGNSILDILKIRDDYSLRDLIENQDELMLDFSSNERDLILNAYFSLIQRESG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
FISGLVCVLHDVTEQQKIDNDRKQFVSNVSHELRTPLTSLRSYIEALSDGAWKDPEVAPG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
FLKVTQEETDRMIRMINELLSLSRMDSGTTRVDMELVNINEMFNYVLDRFDMILKKDDNP
HHEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCC
AKYYTIKREFTKRDLWVEIDTDKFTQVLDNIMNNAIKYSPDGGVVTCRLLETHNQVIISI
CEEEEEEHHHCCCCEEEEECCHHHHHHHHHHHHCCEEECCCCCEEEEEEEECCCEEEEEE
SDQGLGIPRADLGHVFDRFFRVDKARSRAQGGTGLGLAISKEVVQMLGGRIWVDSVEGKG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCC
STFYISLPYEPYEEEDLWDDDSQA
CEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]