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The map label for this gene is hpt [H]

Identifier: 28211841

GI number: 28211841

Start: 2361121

End: 2361657

Strand: Direct

Name: hpt [H]

Synonym: CTC02240

Alternate gene names: 28211841

Gene position: 2361121-2361657 (Clockwise)

Preceding gene: 28211832

Following gene: 28211843

Centisome position: 84.35

GC content: 29.05

Gene sequence:

>537_bases
ATGGAGGTCGCTATGGAAGAAAAAGCAAGAAATATATTAATTACCAAAGAAGAAATACAACAAAAAGTTGAAGCTATGGG
TAAAAAAATATCTAAAGATTATGAAGGAAAAAATTTATATGTACTCTCTTTATTAAGGGGAAGTTTCATGTTTACATCAG
ATTTAGTAAGATATATTACAGTACCTACAAGAATAGGATTTATGACAACTTCTAGTTATGGACATGGAGAAGTTTCTACT
GGAAAAGTTAAAGTAGTTAATGATATACCTGACGATATAAAAGGTATGGATGTATTAATTGTAGATGATATAGTGGATAC
TGGAATAACAATGGATTTTGTTAAAAATCATGTTAAAAGTTTAGGTGCTAACTCAGTTAAATCCTGTGTACTTTTAGATA
AACCTGAAAGAAGAAAGCTTGATTTAGTTCCTGAGTATTGTTGCTTTTCAATCCCAGATGTTTTTGTAGTTGGATACGGA
TTAAACTATGGGGATTTTTATAGAAATATACCTTATATTTTTAATTGGGAAGAATAG

Upstream 100 bases:

>100_bases
ACATATACTACTAAATTAATATCACATGGATTAGATTTTAAAACAGCTGCTGGATTACTTGGTCATACAGTAGAACAAAC
TATTTTAATGAAGATTATAT

Downstream 100 bases:

>100_bases
TTTAATTTAAGTCAAGGAAATAGGAATATAAATGGCTGTATCAAAATAAAATTTTGATACAGCCATTTATATTATTTATT
TTAGCTTCGACTTTAACTTA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MEVAMEEKARNILITKEEIQQKVEAMGKKISKDYEGKNLYVLSLLRGSFMFTSDLVRYITVPTRIGFMTTSSYGHGEVST
GKVKVVNDIPDDIKGMDVLIVDDIVDTGITMDFVKNHVKSLGANSVKSCVLLDKPERRKLDLVPEYCCFSIPDVFVVGYG
LNYGDFYRNIPYIFNWEE

Sequences:

>Translated_178_residues
MEVAMEEKARNILITKEEIQQKVEAMGKKISKDYEGKNLYVLSLLRGSFMFTSDLVRYITVPTRIGFMTTSSYGHGEVST
GKVKVVNDIPDDIKGMDVLIVDDIVDTGITMDFVKNHVKSLGANSVKSCVLLDKPERRKLDLVPEYCCFSIPDVFVVGYG
LNYGDFYRNIPYIFNWEE
>Mature_178_residues
MEVAMEEKARNILITKEEIQQKVEAMGKKISKDYEGKNLYVLSLLRGSFMFTSDLVRYITVPTRIGFMTTSSYGHGEVST
GKVKVVNDIPDDIKGMDVLIVDDIVDTGITMDFVKNHVKSLGANSVKSCVLLDKPERRKLDLVPEYCCFSIPDVFVVGYG
LNYGDFYRNIPYIFNWEE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=177, Percent_Identity=31.638418079096, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI9910262, Length=172, Percent_Identity=31.3953488372093, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI87081689, Length=165, Percent_Identity=43.6363636363636, Blast_Score=150, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17510817, Length=171, Percent_Identity=30.4093567251462, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20213; Mature: 20213

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVAMEEKARNILITKEEIQQKVEAMGKKISKDYEGKNLYVLSLLRGSFMFTSDLVRYIT
CCCCHHHHHCEEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHHHHHHHHH
VPTRIGFMTTSSYGHGEVSTGKVKVVNDIPDDIKGMDVLIVDDIVDTGITMDFVKNHVKS
CCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECHHHCCCCHHHHHHHHHH
LGANSVKSCVLLDKPERRKLDLVPEYCCFSIPDVFVVGYGLNYGDFYRNIPYIFNWEE
CCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHCCCCEEEECCC
>Mature Secondary Structure
MEVAMEEKARNILITKEEIQQKVEAMGKKISKDYEGKNLYVLSLLRGSFMFTSDLVRYIT
CCCCHHHHHCEEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHHHHHHHHH
VPTRIGFMTTSSYGHGEVSTGKVKVVNDIPDDIKGMDVLIVDDIVDTGITMDFVKNHVKS
CCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECHHHCCCCHHHHHHHHHH
LGANSVKSCVLLDKPERRKLDLVPEYCCFSIPDVFVVGYGLNYGDFYRNIPYIFNWEE
CCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]