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The map label for this gene is norM [H]

Identifier: 28211443

GI number: 28211443

Start: 1909434

End: 1910801

Strand: Direct

Name: norM [H]

Synonym: CTC01799

Alternate gene names: 28211443

Gene position: 1909434-1910801 (Clockwise)

Preceding gene: 28211442

Following gene: 28211453

Centisome position: 68.21

GC content: 33.04

Gene sequence:

>1368_bases
TTGAATAAAAAAGCTATTAAAGAAGTACTCTCCATAGCTTTGCCCGCTGTTGGAGAAATGTTTCTTTATGTAATGATTTG
GTTTTTCGACACCGCTATGGTAGGTAAATACGGTGGACAGGTTGCTGTAAGCACTGTTGGATTATGCTCCGAAATGATGG
CTGGTATTATTAATATTTTTATAATACTTGGTATATGTGTAGGGTCTATATCTTTAATTTCTAGAAGCTTAGGTGGAAAT
AACTTTGATTTAGCAGAAGAGTATACATCTATCTCATTTTTTATAGGCATTATGCTCTCATTTTTAATTTCTACAATGGC
ATACACATTTGCACCTAAACTTTTGCATTTTGCAGGAGCTAAAGATCAGGTATTGAGTTTAGGTATAGTATATTTACGAA
TAACCTCTATAGGCTTATTTTTTAATATGCTTATGAATGTTCTAAATTCTGTATTAAGGGGAACAAAAAATACTAAAACT
CCCTTATTTGCCTCGGCTATTGTAAACGTAGTAAACATATTTCTAGATTGGGCTATGATATTTGGGAAAGCTGGTTTTCC
AGAGCTTGGTGTAAAGGGTGCTGCTATAGCTACATCCATAGCACACTTTACTGGATTTTTATTTATCGTTATATATACAT
TTAAGTATTCTCCCTTAAAACCTAGGCTTATACATATAAAGAATATGTCACTACCAAAATTAAAAAATCTTATTAAACTA
TCAATTCCATCTTCTTTGCAAGAAGCTGCTTATAGTATAGCAAGAATATGGGGGATTTTTGTAATGATGGGATTAGGTGA
AGCTTCTTTTGCCGCTAACCAAATAGCTACAACTGTTGAATCCATATCCTACATGCCTGGAACTGGATTTGGAGTAGCTT
GTACCGCATTAGTTGGTCATAAAATAGGAGAAGGAAAGTTTAAAGAAGCTAATGAATATGCTAAAACCTGTGCTTTCTTA
AGTCTTATATTTATGAGCCTTTGTTCAGCTACCTTCTTAATATTTCCTAAATTTATAGTTTCACTATTTATTAATAAAAA
TGAAGTTGAGGTTATAAAATTAGGAATGCTATGTATTATGGTAGCGGCCGCAGAGCAACCTTTTATGGCTCTTTATTTAG
TTTTCGGTGGAGCATTGAAGGGAGCAGGGGATACAAAAACTCCTTTTTATATTTCTCTTATAGCTGCTTGGGCAATTAGA
GTTCCATTTATGCTCTATTTTATAGGTCATCTAAAAGTCTCCGTACACTACAATTGGTGGATTACAGCAGGTCAATGGGC
TTTTCAAGGAATAGCTATATACTTAGTATTTAAAAAGAGATTTTCCCATCCTAAAAAATTACAAGATAATTATTTAGTAA
ATGGATAA

Upstream 100 bases:

>100_bases
CATTTCCATTTAAAAATATGCAATTTTCATTCATTTTATGTTATTATAGGTTTGTTGCAGAAATTTATATATTATTTTAT
TAGTAAAGGGTGATTGATAT

Downstream 100 bases:

>100_bases
TAGCTATTAATTAAAAAAGTAGGCAAAAGCCTACTTTTTATCTTCTCAATATATTTTCCATTATAGAATCTTTCTTATTT
AAAAAATCAGGAATAGATGG

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNKKAIKEVLSIALPAVGEMFLYVMIWFFDTAMVGKYGGQVAVSTVGLCSEMMAGIINIFIILGICVGSISLISRSLGGN
NFDLAEEYTSISFFIGIMLSFLISTMAYTFAPKLLHFAGAKDQVLSLGIVYLRITSIGLFFNMLMNVLNSVLRGTKNTKT
PLFASAIVNVVNIFLDWAMIFGKAGFPELGVKGAAIATSIAHFTGFLFIVIYTFKYSPLKPRLIHIKNMSLPKLKNLIKL
SIPSSLQEAAYSIARIWGIFVMMGLGEASFAANQIATTVESISYMPGTGFGVACTALVGHKIGEGKFKEANEYAKTCAFL
SLIFMSLCSATFLIFPKFIVSLFINKNEVEVIKLGMLCIMVAAAEQPFMALYLVFGGALKGAGDTKTPFYISLIAAWAIR
VPFMLYFIGHLKVSVHYNWWITAGQWAFQGIAIYLVFKKRFSHPKKLQDNYLVNG

Sequences:

>Translated_455_residues
MNKKAIKEVLSIALPAVGEMFLYVMIWFFDTAMVGKYGGQVAVSTVGLCSEMMAGIINIFIILGICVGSISLISRSLGGN
NFDLAEEYTSISFFIGIMLSFLISTMAYTFAPKLLHFAGAKDQVLSLGIVYLRITSIGLFFNMLMNVLNSVLRGTKNTKT
PLFASAIVNVVNIFLDWAMIFGKAGFPELGVKGAAIATSIAHFTGFLFIVIYTFKYSPLKPRLIHIKNMSLPKLKNLIKL
SIPSSLQEAAYSIARIWGIFVMMGLGEASFAANQIATTVESISYMPGTGFGVACTALVGHKIGEGKFKEANEYAKTCAFL
SLIFMSLCSATFLIFPKFIVSLFINKNEVEVIKLGMLCIMVAAAEQPFMALYLVFGGALKGAGDTKTPFYISLIAAWAIR
VPFMLYFIGHLKVSVHYNWWITAGQWAFQGIAIYLVFKKRFSHPKKLQDNYLVNG
>Mature_455_residues
MNKKAIKEVLSIALPAVGEMFLYVMIWFFDTAMVGKYGGQVAVSTVGLCSEMMAGIINIFIILGICVGSISLISRSLGGN
NFDLAEEYTSISFFIGIMLSFLISTMAYTFAPKLLHFAGAKDQVLSLGIVYLRITSIGLFFNMLMNVLNSVLRGTKNTKT
PLFASAIVNVVNIFLDWAMIFGKAGFPELGVKGAAIATSIAHFTGFLFIVIYTFKYSPLKPRLIHIKNMSLPKLKNLIKL
SIPSSLQEAAYSIARIWGIFVMMGLGEASFAANQIATTVESISYMPGTGFGVACTALVGHKIGEGKFKEANEYAKTCAFL
SLIFMSLCSATFLIFPKFIVSLFINKNEVEVIKLGMLCIMVAAAEQPFMALYLVFGGALKGAGDTKTPFYISLIAAWAIR
VPFMLYFIGHLKVSVHYNWWITAGQWAFQGIAIYLVFKKRFSHPKKLQDNYLVNG

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=400, Percent_Identity=23.25, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI48994890, Length=409, Percent_Identity=23.7163814180929, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49988; Mature: 49988

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKAIKEVLSIALPAVGEMFLYVMIWFFDTAMVGKYGGQVAVSTVGLCSEMMAGIINIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHH
IILGICVGSISLISRSLGGNNFDLAEEYTSISFFIGIMLSFLISTMAYTFAPKLLHFAGA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KDQVLSLGIVYLRITSIGLFFNMLMNVLNSVLRGTKNTKTPLFASAIVNVVNIFLDWAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGKAGFPELGVKGAAIATSIAHFTGFLFIVIYTFKYSPLKPRLIHIKNMSLPKLKNLIKL
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHH
SIPSSLQEAAYSIARIWGIFVMMGLGEASFAANQIATTVESISYMPGTGFGVACTALVGH
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
KIGEGKFKEANEYAKTCAFLSLIFMSLCSATFLIFPKFIVSLFINKNEVEVIKLGMLCIM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VAAAEQPFMALYLVFGGALKGAGDTKTPFYISLIAAWAIRVPFMLYFIGHLKVSVHYNWW
HHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEE
ITAGQWAFQGIAIYLVFKKRFSHPKKLQDNYLVNG
EECCCHHHHHHHHHEEEHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure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EECCCHHHHHHHHHEEEHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]