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The map label for this gene is hdc [H]

Identifier: 28211154

GI number: 28211154

Start: 1601044

End: 1602771

Strand: Direct

Name: hdc [H]

Synonym: CTC01478

Alternate gene names: 28211154

Gene position: 1601044-1602771 (Clockwise)

Preceding gene: 28211152

Following gene: 28211163

Centisome position: 57.2

GC content: 31.54

Gene sequence:

>1728_bases
ATGAAAAATCCAATGACACAACCTACAAAAGATCCTAATACAGTTTATCCAAAAGTTCCAGGAATAGATTATGATAAATT
CAAACTTTCGGAAGATAAGATGACTTCAAAACAAATTAATGATGCTTTAGAAGAATTACACAATTATATATCTAATCAAC
AAATAAATTTTCTAGGGTATCAAATTAATCAAAGCTTTAATTATATGAAGGATTTAAAAGAATATTTAAATGTTCATATG
AATAATATAGGAGACCCATTTGTATCAGGAAACTTCACGGTAAACACAAAGTTTTTAGAACGTGCTGTTCTTGATTATTT
CGCTTCTCTTTGGAATGCACAATGGCCCCATGAATCCAAGGGTGATTCTAATACAAATGATTGGAAAAATAGCTACTGGG
GATATGTAGTTTCCATGGGAAGTACAGAAGCTAACTTCTTTGGGATATGGAATGCTCGTGATTATTTATCTGGAAAAGCA
CTCTTACTTGACACAAGTACACATAAGCGAGCAAAGTCTGCAAGTATTAATGGAAATCCTCAATCTGTAGAACCAAGAGT
TTTAAACTATCAGGCAAAATCCTTAGAAGATAATCCTAATATGTATACACCTATTGCCTTTTACTCACAGGATACTCATT
ATTCTATTATAAAAGGAATGAGAATTCTTAACTTCACAACCTTTAATGAGGCTGGAAGTGGTAAATTTGAATGCCCATTA
AAATATCCAGAGGATTACCCAAAGGGGTTTTCAATTAATTACTTAGATGAAAATGGATGGCCCTTTGAAGTTCCCTCAAA
TAATGATGGATCAGTTTTCATACCTGCTTTGAAGAAACTAGTAGAAGCATTTGCAAGTAAAGGATATCCTATATTCGTAA
ACTTCAACTATGGAACTACCTTTAAAGGTTCTTATGATAATGTTGAAAAAGCTATTGATGAATTAGTGCCTATATTAAAA
AAATATAACTTATACGAAAGAGAAATTATTTTTGACAAAAATAATAAAAATTCAGATACTAGAACAGGTTTCTGGTTTCA
TGTAGATGGAGCATTGGGAGCTGCTTACATGCCATTTTTAGAAATGACTACTGACAATGAAGATTTCCCAGTTTTTGATT
TTAGATTAAAAGATGTTCATTCTATATCAATGAGTGGTCATAAATGGATTGGAGTACCTTGGCCTTGTGGAATATATATG
TCTAAAATAAAGTATCAACTTCTTCCACCAGATAATCCAAACTACATTGGATCTCCAGATAGCACCTTCGCAGGTTCTAG
AAATGCTTTCTCTTCCCTTATTTTATGGTACTATATAGCTACTCATTCCTATGAGGATTGCAAAAACATGATACTTGATT
GTCAGGATACTGCAAAATATACAGTAGAAAAACTAAATGAGCTTTCTAAAAAGTTAGGTATAGATTTATGGGTAGAATAT
TCATCTAAATCTCTAACAATTAGATTTAAAGAAGCTAATCCCGACATTGTATTTAAATACTCACTATCAGGAGAAATATT
ATATGTTAATGGAGAAAAAAGAGCATATTCGCACATATATATTATGCCTCATGTTACAAAGGATCTTATTGATAAATTCA
TAAAAGATTTGAGTAAACCTGGAGCATTTCCAGAACAGGTTTCACATTTAGAAAAGGATGGTGTGAATTTTAATTCAAAT
TCCCATAAAGGTATTTATGTCCCTCAAATAGGACGTGGATTTAAATAA

Upstream 100 bases:

>100_bases
TACAAAACATTCATATGTATATAGGGTGTAAACCTTTTAAACGTAAAACAAGTAGTTTTTACACTACTTACCAATATACT
TATAGAAAGGGTGATTTAAA

Downstream 100 bases:

>100_bases
AATTTAATAATGAAAAAGAAACCCTCCTTGTGTTTAAATGAAAGTGACCAAACAACCATGAACAAGAAGGGTTTCCTTTT
TAAACATTCCATATAAATGG

Product: putative histidine decarboxylase

Products: NA

Alternate protein names: HDC [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQINFLGYQINQSFNYMKDLKEYLNVHM
NNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESKGDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKA
LLLDTSTHKRAKSASINGNPQSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPL
KYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTTFKGSYDNVEKAIDELVPILK
KYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFLEMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYM
SKIKYQLLPPDNPNYIGSPDSTFAGSRNAFSSLILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGIDLWVEY
SSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIKDLSKPGAFPEQVSHLEKDGVNFNSN
SHKGIYVPQIGRGFK

Sequences:

>Translated_575_residues
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQINFLGYQINQSFNYMKDLKEYLNVHM
NNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESKGDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKA
LLLDTSTHKRAKSASINGNPQSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPL
KYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTTFKGSYDNVEKAIDELVPILK
KYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFLEMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYM
SKIKYQLLPPDNPNYIGSPDSTFAGSRNAFSSLILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGIDLWVEY
SSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIKDLSKPGAFPEQVSHLEKDGVNFNSN
SHKGIYVPQIGRGFK
>Mature_575_residues
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQINFLGYQINQSFNYMKDLKEYLNVHM
NNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESKGDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKA
LLLDTSTHKRAKSASINGNPQSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPL
KYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTTFKGSYDNVEKAIDELVPILK
KYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFLEMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYM
SKIKYQLLPPDNPNYIGSPDSTFAGSRNAFSSLILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGIDLWVEY
SSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIKDLSKPGAFPEQVSHLEKDGVNFNSN
SHKGIYVPQIGRGFK

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.22 [H]

Molecular weight: Translated: 65958; Mature: 65958

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQINFLGY
CCCCCCCCCCCCCEECCCCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
QINQSFNYMKDLKEYLNVHMNNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESK
EECCCHHHHHHHHHHHHHHHCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
GDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKALLLDTSTHKRAKSASINGNP
CCCCCCCCCCCCCEEEEEECCCCCCEEEEECCHHHCCCCEEEEECCCCCHHCCCCCCCCC
QSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPL
CCCCCCEEEEEHHCCCCCCCEEEEEEEECCCCCHHHHCCCEEEEEEECCCCCCCEEECCC
KYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTT
CCCCCCCCCCEEEEECCCCCEEECCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCC
FKGSYDNVEKAIDELVPILKKYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFL
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHCEE
EMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYMSKIKYQLLPPDNPNYIGSPD
EECCCCCCCCEEEEEECCEEEEECCCCEEECCCCCHHHHEEEEEEEECCCCCCCCCCCCC
STFAGSRNAFSSLILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGIDLWVEY
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIKDLSKP
CCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHCC
GAFPEQVSHLEKDGVNFNSNSHKGIYVPQIGRGFK
CCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQINFLGY
CCCCCCCCCCCCCEECCCCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
QINQSFNYMKDLKEYLNVHMNNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESK
EECCCHHHHHHHHHHHHHHHCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
GDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKALLLDTSTHKRAKSASINGNP
CCCCCCCCCCCCCEEEEEECCCCCCEEEEECCHHHCCCCEEEEECCCCCHHCCCCCCCCC
QSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPL
CCCCCCEEEEEHHCCCCCCCEEEEEEEECCCCCHHHHCCCEEEEEEECCCCCCCEEECCC
KYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTT
CCCCCCCCCCEEEEECCCCCEEECCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCC
FKGSYDNVEKAIDELVPILKKYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFL
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHCEE
EMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYMSKIKYQLLPPDNPNYIGSPD
EECCCCCCCCEEEEEECCEEEEECCCCEEECCCCCHHHHEEEEEEEECCCCCCCCCCCCC
STFAGSRNAFSSLILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGIDLWVEY
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIKDLSKP
CCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHCC
GAFPEQVSHLEKDGVNFNSNSHKGIYVPQIGRGFK
CCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]