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The map label for this gene is prpC [H]

Identifier: 28210912

GI number: 28210912

Start: 1311558

End: 1312367

Strand: Direct

Name: prpC [H]

Synonym: CTC01224

Alternate gene names: 28210912

Gene position: 1311558-1312367 (Clockwise)

Preceding gene: 28210911

Following gene: 28210913

Centisome position: 46.85

GC content: 30.37

Gene sequence:

>810_bases
ATGCAGCCTGTGGACAGCTTCGAAGAAGATATGTTAAAAATAATAGTAAAGAGGTGTAAATCTATGGTGGGTATGATAAC
AGATGTTGGGAATTTTAGAAAGATAAATGAAGATTATGTTGGATACTATATAGATGAGACAAAAGAAATATATATAGTTG
CTGATGGCATGGGAGGACATAATGCAGGAGAAGTTGCTAGTGAATTGGCAGTTAATACTGTAATAGAGTACTTGAATAAT
ATGGAAGATACAGAAGATATAGATTGGCAACTTACAAAAGCCATAAAGAAAGCTAATGAGAATATATTTAAGCTGGCATG
TACAAAAAAGGAATATGAAGGTATGGGAACTACTATAACAGCGGCTTTTATAAAAAAAGAAAAAATAGTAGTTGCAAATG
TAGGAGATAGTAGTTGTTATATTATTGACAAAGATGATAAAATACTTAAAGTAACTAAAGACCACTCATTAGTTCAACAA
TTAATTGATAATGGAAGTATAACAGAAGAAGAAGCTCTTATACATCCAAATAAAAATGTTATAACAAGAGCCTTAGGTAC
AAGTGACTTAGTTATAGTAGATACATTCTTATTAGATTTAAAAGAAATAAAAAAGGCAATACTTTGTACTGATGGACTAA
CAAATGATATTACACCAAAAGAAATGTATGATATAATAATAACCAATAATAACGAAAATGCTTGCAGAATTTTACTAGAA
TCCTGCAAAGAAAAAGGTGGGAAAGATAACATATCAGTCATTGTATTTGAAGGAGAGTGTAGTGATGATAGGCACATTGC
TAGGAAATAG

Upstream 100 bases:

>100_bases
TTTAAAAGTTCTTCCACCAATAGGATTAAAAACTTTAGTAATATATTACTAAAAAGTGGCATACAAACTACTATAAGAAG
AGAAATGGGCTCGGACATAA

Downstream 100 bases:

>100_bases
ATATGAATTATTAGAAAAAGTTGGAGAAGGTGGAATGGCAGAGGTCTATAAAGCAAAATGCCATTTTCTTAACAGATATG
TAGCAGTAAAGATTTTAAAA

Product: phosphoprotein phosphatase 2C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MQPVDSFEEDMLKIIVKRCKSMVGMITDVGNFRKINEDYVGYYIDETKEIYIVADGMGGHNAGEVASELAVNTVIEYLNN
MEDTEDIDWQLTKAIKKANENIFKLACTKKEYEGMGTTITAAFIKKEKIVVANVGDSSCYIIDKDDKILKVTKDHSLVQQ
LIDNGSITEEEALIHPNKNVITRALGTSDLVIVDTFLLDLKEIKKAILCTDGLTNDITPKEMYDIIITNNNENACRILLE
SCKEKGGKDNISVIVFEGECSDDRHIARK

Sequences:

>Translated_269_residues
MQPVDSFEEDMLKIIVKRCKSMVGMITDVGNFRKINEDYVGYYIDETKEIYIVADGMGGHNAGEVASELAVNTVIEYLNN
MEDTEDIDWQLTKAIKKANENIFKLACTKKEYEGMGTTITAAFIKKEKIVVANVGDSSCYIIDKDDKILKVTKDHSLVQQ
LIDNGSITEEEALIHPNKNVITRALGTSDLVIVDTFLLDLKEIKKAILCTDGLTNDITPKEMYDIIITNNNENACRILLE
SCKEKGGKDNISVIVFEGECSDDRHIARK
>Mature_269_residues
MQPVDSFEEDMLKIIVKRCKSMVGMITDVGNFRKINEDYVGYYIDETKEIYIVADGMGGHNAGEVASELAVNTVIEYLNN
MEDTEDIDWQLTKAIKKANENIFKLACTKKEYEGMGTTITAAFIKKEKIVVANVGDSSCYIIDKDDKILKVTKDHSLVQQ
LIDNGSITEEEALIHPNKNVITRALGTSDLVIVDTFLLDLKEIKKAILCTDGLTNDITPKEMYDIIITNNNENACRILLE
SCKEKGGKDNISVIVFEGECSDDRHIARK

Specific function: Protein phosphatase that dephosphorylates prkC and fusA (elongation factor G). PrpC and prkC are cotranscribed, which suggests that they form a functional couple in vivo, prpC's primary role being possibly to counter the action of prkC. May be involved in

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 30128; Mature: 30128

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPVDSFEEDMLKIIVKRCKSMVGMITDVGNFRKINEDYVGYYIDETKEIYIVADGMGGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEECCCEEEEEEEECCCCC
NAGEVASELAVNTVIEYLNNMEDTEDIDWQLTKAIKKANENIFKLACTKKEYEGMGTTIT
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHCCCCCEEE
AAFIKKEKIVVANVGDSSCYIIDKDDKILKVTKDHSLVQQLIDNGSITEEEALIHPNKNV
EEEEECCEEEEEECCCCEEEEEECCCCEEEEECHHHHHHHHHCCCCCCCCCEEECCCCHH
ITRALGTSDLVIVDTFLLDLKEIKKAILCTDGLTNDITPKEMYDIIITNNNENACRILLE
EEHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECCCCHHHHHHHH
SCKEKGGKDNISVIVFEGECSDDRHIARK
HHHHCCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MQPVDSFEEDMLKIIVKRCKSMVGMITDVGNFRKINEDYVGYYIDETKEIYIVADGMGGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEECCCEEEEEEEECCCCC
NAGEVASELAVNTVIEYLNNMEDTEDIDWQLTKAIKKANENIFKLACTKKEYEGMGTTIT
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHCCCCCEEE
AAFIKKEKIVVANVGDSSCYIIDKDDKILKVTKDHSLVQQLIDNGSITEEEALIHPNKNV
EEEEECCEEEEEECCCCEEEEEECCCCEEEEECHHHHHHHHHCCCCCCCCCEEECCCCHH
ITRALGTSDLVIVDTFLLDLKEIKKAILCTDGLTNDITPKEMYDIIITNNNENACRILLE
EEHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECCCCHHHHHHHH
SCKEKGGKDNISVIVFEGECSDDRHIARK
HHHHCCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]