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The map label for this gene is lytC [H]

Identifier: 28210890

GI number: 28210890

Start: 1285902

End: 1287380

Strand: Direct

Name: lytC [H]

Synonym: CTC01202

Alternate gene names: 28210890

Gene position: 1285902-1287380 (Clockwise)

Preceding gene: 28210889

Following gene: 28210891

Centisome position: 45.94

GC content: 30.97

Gene sequence:

>1479_bases
GTGAAAAAAAGAAATTTAAGTATTATTATTGCATTAACATTAGGAGTAACAATCATATTTAAATCACAAGTTAATGCAGC
AAAATTAGGAAAGAGATTATCGGGAACCAACAGATATGAAACTGGCTCTAAAATAGTAAGGGAAGGATGGACAAGTTCAG
ATTATGCAATAATAGCTAGCGGAGAGGATTTTGCTGATGCACTTTGTGCAGCGCCTTTAGCTAAAAAATACAATGCACCA
ATTTTACTAACTGGAAAATTCCACTTAGACTTAAATACAGAAAATGAATTAAAAAGACTTAATGTAAAAAATGTATTTAT
AGTAGGGGGAACTGGAGTTGTGTCAGAGAATATCAAAGATAAATTAACAAATATGAATATTAAAACTACTAGAATATATG
GACAAAATAGATTTGAAACATCTGTACAAGTAGCTAAAAATTTAGATGATTCTAATGGAGTGATAATTACAAATGGATTT
GGTTTTGCAGATGCCTTGTCAATAGCACCAGTAGCTGCACAAAAAGAAATGCCAATATTACTTACTGATAAGAAGGATTT
ACCACAAGAAGTTAAAGTATTTTTAAAGAATAAAGCTTATAGTATAAGTTATATAGTTGGTGGAAGCGGAGTTGTAAGTA
ATAAAATAGCTTCAAATTTAAAAAATAACATAAGACTTGAAGGGAAAAGCAGATATGCTACAAATGCATCAGTATTAAAT
CATTTTAATAGTGAATTTAACTATGATAAGGTTTATATAGCTTCAGGAGAAAACTATCCAGATGCCTTGTCAGGAAGCGC
TCTAGCAGCTTTAAGTAATTCTTTCTTAGTTTTAGTAGGAAATTCCGTTGATCCTCTAGTAATGGATTCAGTAGATTTAA
TACATAATAAGATTAAGGATTTAATGGTATTAGGTGGAAAAAGTGTGGTTTCTGATACAGTAGTAAATAATATTTTAGAT
GGAAAAGAAACTGTACCAGTAATTCCACTTTTGGGAGAATCAAAGGTTACTTTAGAAACTATGAAAAATTGGGCTAAAAG
CAGAGGGGCTACTGAAGAATTTATTAACAATGCTGATTTATATTTTAAATATGGTAAATTAACAGGTATAAGGTCAGATA
TATTATATGCTCAATCTGCAAAGGAAACTGGGTTCGGTAAATTCGGTGGAGCGGTTACAGAGGATATGAATAACTTTGCT
GGAATTAAAATTAAAGATGCCACGGGAGATAAAAAAGAGGACCATGAAACTTTTTCTACTCCAGAAGATGGGGTTAGAGC
ACATTTTAATCATATAGCTGCTTATTGTGGTGTTAATCCTATAGGACAACCTCACCCGCGTTATTTTGTAGTAAAATCTT
GTAGCTGGTCAGGAAAAATAAAAACAGTAGGAGAATTAGCAGGAAAGTATTGTCCAAACCCTAGATACTCTAGAGATTTA
ATAAATAATTTTTTAAATGATTTATTAAAGTTTAAATAA

Upstream 100 bases:

>100_bases
ATCAGCTAAAAATCAAGTCTTTTTTTATTTTCTAAAATTATGTATTATAATATTAGATTTTGTCATTTTATGATATTATT
TAAGAGATTGGAGGATTATT

Downstream 100 bases:

>100_bases
AAAAATACAGAGTGTGAAGTGAATAAGGGGTGGATTAAAATGAATACAAAACAATTAATTGAATTTATGTCTATTGCAGA
AAAATTAAAAAACAATACAC

Product: N-acetylmuramoyl-L-alanine amidase-like protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKKRNLSIIIALTLGVTIIFKSQVNAAKLGKRLSGTNRYETGSKIVREGWTSSDYAIIASGEDFADALCAAPLAKKYNAP
ILLTGKFHLDLNTENELKRLNVKNVFIVGGTGVVSENIKDKLTNMNIKTTRIYGQNRFETSVQVAKNLDDSNGVIITNGF
GFADALSIAPVAAQKEMPILLTDKKDLPQEVKVFLKNKAYSISYIVGGSGVVSNKIASNLKNNIRLEGKSRYATNASVLN
HFNSEFNYDKVYIASGENYPDALSGSALAALSNSFLVLVGNSVDPLVMDSVDLIHNKIKDLMVLGGKSVVSDTVVNNILD
GKETVPVIPLLGESKVTLETMKNWAKSRGATEEFINNADLYFKYGKLTGIRSDILYAQSAKETGFGKFGGAVTEDMNNFA
GIKIKDATGDKKEDHETFSTPEDGVRAHFNHIAAYCGVNPIGQPHPRYFVVKSCSWSGKIKTVGELAGKYCPNPRYSRDL
INNFLNDLLKFK

Sequences:

>Translated_492_residues
MKKRNLSIIIALTLGVTIIFKSQVNAAKLGKRLSGTNRYETGSKIVREGWTSSDYAIIASGEDFADALCAAPLAKKYNAP
ILLTGKFHLDLNTENELKRLNVKNVFIVGGTGVVSENIKDKLTNMNIKTTRIYGQNRFETSVQVAKNLDDSNGVIITNGF
GFADALSIAPVAAQKEMPILLTDKKDLPQEVKVFLKNKAYSISYIVGGSGVVSNKIASNLKNNIRLEGKSRYATNASVLN
HFNSEFNYDKVYIASGENYPDALSGSALAALSNSFLVLVGNSVDPLVMDSVDLIHNKIKDLMVLGGKSVVSDTVVNNILD
GKETVPVIPLLGESKVTLETMKNWAKSRGATEEFINNADLYFKYGKLTGIRSDILYAQSAKETGFGKFGGAVTEDMNNFA
GIKIKDATGDKKEDHETFSTPEDGVRAHFNHIAAYCGVNPIGQPHPRYFVVKSCSWSGKIKTVGELAGKYCPNPRYSRDL
INNFLNDLLKFK
>Mature_492_residues
MKKRNLSIIIALTLGVTIIFKSQVNAAKLGKRLSGTNRYETGSKIVREGWTSSDYAIIASGEDFADALCAAPLAKKYNAP
ILLTGKFHLDLNTENELKRLNVKNVFIVGGTGVVSENIKDKLTNMNIKTTRIYGQNRFETSVQVAKNLDDSNGVIITNGF
GFADALSIAPVAAQKEMPILLTDKKDLPQEVKVFLKNKAYSISYIVGGSGVVSNKIASNLKNNIRLEGKSRYATNASVLN
HFNSEFNYDKVYIASGENYPDALSGSALAALSNSFLVLVGNSVDPLVMDSVDLIHNKIKDLMVLGGKSVVSDTVVNNILD
GKETVPVIPLLGESKVTLETMKNWAKSRGATEEFINNADLYFKYGKLTGIRSDILYAQSAKETGFGKFGGAVTEDMNNFA
GIKIKDATGDKKEDHETFSTPEDGVRAHFNHIAAYCGVNPIGQPHPRYFVVKSCSWSGKIKTVGELAGKYCPNPRYSRDL
INNFLNDLLKFK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 53722; Mature: 53722

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRNLSIIIALTLGVTIIFKSQVNAAKLGKRLSGTNRYETGSKIVREGWTSSDYAIIAS
CCCCCEEEEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEC
GEDFADALCAAPLAKKYNAPILLTGKFHLDLNTENELKRLNVKNVFIVGGTGVVSENIKD
CCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHCCCCEEEEECCCCHHHCCHHH
KLTNMNIKTTRIYGQNRFETSVQVAKNLDDSNGVIITNGFGFADALSIAPVAAQKEMPIL
HHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCEE
LTDKKDLPQEVKVFLKNKAYSISYIVGGSGVVSNKIASNLKNNIRLEGKSRYATNASVLN
EECCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCHHHHH
HFNSEFNYDKVYIASGENYPDALSGSALAALSNSFLVLVGNSVDPLVMDSVDLIHNKIKD
HHCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
LMVLGGKSVVSDTVVNNILDGKETVPVIPLLGESKVTLETMKNWAKSRGATEEFINNADL
HEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHCCCCE
YFKYGKLTGIRSDILYAQSAKETGFGKFGGAVTEDMNNFAGIKIKDATGDKKEDHETFST
EEEECCCCCCHHHHHEECCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
PEDGVRAHFNHIAAYCGVNPIGQPHPRYFVVKSCSWSGKIKTVGELAGKYCPNPRYSRDL
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHH
INNFLNDLLKFK
HHHHHHHHHCCC
>Mature Secondary Structure
MKKRNLSIIIALTLGVTIIFKSQVNAAKLGKRLSGTNRYETGSKIVREGWTSSDYAIIAS
CCCCCEEEEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEC
GEDFADALCAAPLAKKYNAPILLTGKFHLDLNTENELKRLNVKNVFIVGGTGVVSENIKD
CCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHCCCCEEEEECCCCHHHCCHHH
KLTNMNIKTTRIYGQNRFETSVQVAKNLDDSNGVIITNGFGFADALSIAPVAAQKEMPIL
HHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCEE
LTDKKDLPQEVKVFLKNKAYSISYIVGGSGVVSNKIASNLKNNIRLEGKSRYATNASVLN
EECCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCHHHHH
HFNSEFNYDKVYIASGENYPDALSGSALAALSNSFLVLVGNSVDPLVMDSVDLIHNKIKD
HHCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
LMVLGGKSVVSDTVVNNILDGKETVPVIPLLGESKVTLETMKNWAKSRGATEEFINNADL
HEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHCCCCE
YFKYGKLTGIRSDILYAQSAKETGFGKFGGAVTEDMNNFAGIKIKDATGDKKEDHETFST
EEEECCCCCCHHHHHEECCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
PEDGVRAHFNHIAAYCGVNPIGQPHPRYFVVKSCSWSGKIKTVGELAGKYCPNPRYSRDL
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHH
INNFLNDLLKFK
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]