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The map label for this gene is isdE [H]

Identifier: 28210884

GI number: 28210884

Start: 1278532

End: 1279422

Strand: Direct

Name: isdE [H]

Synonym: CTC01195

Alternate gene names: 28210884

Gene position: 1278532-1279422 (Clockwise)

Preceding gene: 28210883

Following gene: 28210885

Centisome position: 45.67

GC content: 28.51

Gene sequence:

>891_bases
ATGAAGAAAATTTTAACTTTAATAATAACTGTTTTAATGGGTGTAATGCTAACTTCCTGTGATAGAGGTAGTAGTGTAAA
TCAAAAAGAAAACCCTTCAAATAAAAAAAGCGAAGATGCAAGAATAATAGGTGGAAGCGTTGCAATAGCTGAAATGCTTT
CAAAACTAGATATTAAAATGATAGGAAGAGCAAGCACTCAATATGAAATATCAGATAAAATAAAAGACCTTCCAGAAATA
TGTCTTCCAATGAGCCCGGATTTAGAGAAAATTAAAACTTTAACACCAGATGTATACATAACCTCTGGTGCATTACAAGA
GATGATAGGAGATAAACTTAAAGAAAGTGGAATGGAAACCATTTATGCTAATTTAGATTCCTATGATTCTGTAAAAGATA
CTATAAAAGAGTTATCTAAGAAGTTTGGAAAAGAAGAAAATGGAATAAAGCTTGTTAAAGAAATTGAAGAAAGTGAAAGA
CAAATTTTAAAAGAGGTTGATACTAATAAAAAAGTAAAAGTTATGATTTTATTTGGAGCACCAGGGCACTTTATGCTAGC
TAGTGAAAATTCTTTTGTAGGAAGCCTTATTACAAAATTAGGAGCAGAAAATATTGCATCTAAAATTAAATTTAAAGGTC
AATATGTACCTTTTTCATTAGAAACTGCATTAAAGGAAGATCCTGATGTAATTCTTAGAATGTATCATGGATATATAGAT
GAAGCAAAAAAGCAAGTAGATGATGAATTTAAAAATAATCCTCAGTGGAAAAATTTCAAGGCAATAAGAGAAAATAAAGT
ATATGACTTAGATCCTAAATATTTTGGAGTTACAGGAGACATAAAACAAGTAGAGTCATTAAAAATGATGAAAGATTATT
TATATAAATAA

Upstream 100 bases:

>100_bases
AATAATAAAAACAAAATTTAATTAAACTAAAGTTCAGATGGAATTTTAATTCTATCTGAACTAAGTTTTACTCCAGAACA
GGAATAGGAGGAAATTAGGT

Downstream 100 bases:

>100_bases
AGTAAGGAAATGATTAATGATATGAAAAATATGAAAGAAATAAATAAGATAATTATTATATTACTCTCTTTTTTATTATT
AATAAGTTTAATAGTTATAA

Product: iron(III) dicitrate-binding periplasmic protein

Products: NA

Alternate protein names: Iron-regulated surface determinant protein E; Staphylococcal iron-regulated protein F [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKKILTLIITVLMGVMLTSCDRGSSVNQKENPSNKKSEDARIIGGSVAIAEMLSKLDIKMIGRASTQYEISDKIKDLPEI
CLPMSPDLEKIKTLTPDVYITSGALQEMIGDKLKESGMETIYANLDSYDSVKDTIKELSKKFGKEENGIKLVKEIEESER
QILKEVDTNKKVKVMILFGAPGHFMLASENSFVGSLITKLGAENIASKIKFKGQYVPFSLETALKEDPDVILRMYHGYID
EAKKQVDDEFKNNPQWKNFKAIRENKVYDLDPKYFGVTGDIKQVESLKMMKDYLYK

Sequences:

>Translated_296_residues
MKKILTLIITVLMGVMLTSCDRGSSVNQKENPSNKKSEDARIIGGSVAIAEMLSKLDIKMIGRASTQYEISDKIKDLPEI
CLPMSPDLEKIKTLTPDVYITSGALQEMIGDKLKESGMETIYANLDSYDSVKDTIKELSKKFGKEENGIKLVKEIEESER
QILKEVDTNKKVKVMILFGAPGHFMLASENSFVGSLITKLGAENIASKIKFKGQYVPFSLETALKEDPDVILRMYHGYID
EAKKQVDDEFKNNPQWKNFKAIRENKVYDLDPKYFGVTGDIKQVESLKMMKDYLYK
>Mature_296_residues
MKKILTLIITVLMGVMLTSCDRGSSVNQKENPSNKKSEDARIIGGSVAIAEMLSKLDIKMIGRASTQYEISDKIKDLPEI
CLPMSPDLEKIKTLTPDVYITSGALQEMIGDKLKESGMETIYANLDSYDSVKDTIKELSKKFGKEENGIKLVKEIEESER
QILKEVDTNKKVKVMILFGAPGHFMLASENSFVGSLITKLGAENIASKIKFKGQYVPFSLETALKEDPDVILRMYHGYID
EAKKQVDDEFKNNPQWKNFKAIRENKVYDLDPKYFGVTGDIKQVESLKMMKDYLYK

Specific function: Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors t

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019957
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 33448; Mature: 33448

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILTLIITVLMGVMLTSCDRGSSVNQKENPSNKKSEDARIIGGSVAIAEMLSKLDIKM
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCHHH
IGRASTQYEISDKIKDLPEICLPMSPDLEKIKTLTPDVYITSGALQEMIGDKLKESGMET
HCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHH
IYANLDSYDSVKDTIKELSKKFGKEENGIKLVKEIEESERQILKEVDTNKKVKVMILFGA
HHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
PGHFMLASENSFVGSLITKLGAENIASKIKFKGQYVPFSLETALKEDPDVILRMYHGYID
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCHHHHHHHHHHHHH
EAKKQVDDEFKNNPQWKNFKAIRENKVYDLDPKYFGVTGDIKQVESLKMMKDYLYK
HHHHHHHHHHCCCCCCCCHHHHHCCCCEECCCCEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKILTLIITVLMGVMLTSCDRGSSVNQKENPSNKKSEDARIIGGSVAIAEMLSKLDIKM
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCHHH
IGRASTQYEISDKIKDLPEICLPMSPDLEKIKTLTPDVYITSGALQEMIGDKLKESGMET
HCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHH
IYANLDSYDSVKDTIKELSKKFGKEENGIKLVKEIEESERQILKEVDTNKKVKVMILFGA
HHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
PGHFMLASENSFVGSLITKLGAENIASKIKFKGQYVPFSLETALKEDPDVILRMYHGYID
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCHHHHHHHHHHHHH
EAKKQVDDEFKNNPQWKNFKAIRENKVYDLDPKYFGVTGDIKQVESLKMMKDYLYK
HHHHHHHHHHCCCCCCCCHHHHHCCCCEECCCCEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA