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The map label for this gene is iscS [H]

Identifier: 28210752

GI number: 28210752

Start: 1119134

End: 1120336

Strand: Direct

Name: iscS [H]

Synonym: CTC01050

Alternate gene names: 28210752

Gene position: 1119134-1120336 (Clockwise)

Preceding gene: 28210751

Following gene: 28210753

Centisome position: 39.98

GC content: 33.0

Gene sequence:

>1203_bases
ATGGACAGAAAAGTTGTATATATGGATTACTCAGCTACTACATATACAAAGCCAGAGGTTTTAGAAGAAATGCTTCCTTA
TTTTACAGGTAAATTTGGAAATCCATCTTCAAAATTTTACTCAGTTTCTCAAGACCCAATTGAAGCTATTGATAGTGCAA
GGGAAAGAGTAGCTAAGGGTATTAATTCAGAAAAAGATGAGATTTACTTTACTAGCGGAGGTTCTGAGGCAGATAACTGG
GCAATTAAAGGAGTGGCTTTTGCAAATAAAAATAAAGGAAATCATATAATAACTACAGCTATAGAACATCATGCAGTACT
TCACAGTTGTGAGTTTCTAAAGAGGAATGGTTTTGAAATAACATATTTACCAGTAAACGATGAAGGATTAATTAGTTTAG
AAGATTTAAAAAATGCTATAAAAGACAATACAATCCTTGTAACTATAATGTTTGCTAATAACGAAATTGGAGCTATCCAA
TCTATAAAAGAAATTGGGAAAATATGCAGAGAAAGAAAGGTTTTATTCCATACAGATGCAGTTCAAGCAATGGGGCATGT
TCCTATAGATGTAAAAGATATGAATATAGATATGTTATCCATGGCTGGGCATAAATTTTATGGACCAAAAGGAATAGGGG
CTTTATATATAAGAAAAGGTGTTAGAATTGAAAACTTAATTCATGGTGGTGGGCAAGAAAAAGGAAAAAGAGGTACAACA
GAAAATGTTCCAGGTATAGTAGGTATTGGTAAGGCCATAGAATTAGCTACAGAACATCTTTATGAAGAAAAAGAAAGACT
AACTAAAATGAGAGATAGACTTATAGAGGGATTAATGAATAAAATACCTCATACAAAATTAAATGGACCAACAGGAGATA
AGAGATTACCAAACAACGTAAATTTGAGCTTTATAGGTATAGAGGGAGAAACTCTATTACTAGATTTAGATTTTGAAGGA
GTATGTGCATCCACAGGAAGTGCCTGTGCTTCAGGTTCTTTAGATCCTTCCCATGTCTTATTATCCATTGGTTTAAGTCA
TGGAATTGCCCATGGATCTTTAAGGCTTACTCTAGGAGAAGGTAGTACAGAAGAAGATGTAGATTATATATTAAATACGC
TTCCAGATATAGTAAAAAGAAGACGTGAAATGTCACCTTATTGGGAAGATTATTTAAAAAGTCTAAAGGAAGGGGAGAAA
TAA

Upstream 100 bases:

>100_bases
TTAAAGAAAGTATTGATAATGTAACAAAGACTACAACACTTCAAGATATGGTAGATGACTATTATAAATTAAACAGTTGT
AAAGGAAAGGGGAAATAAAA

Downstream 100 bases:

>100_bases
TTATGATGCCATATAGTGATAAAGTTATGGAACATTTTAGAAATCCAAGAAATGTAGGAGAAATTTCAGATGCAAATGGA
GTTGGAGAAGTTGGAAATCC

Product: cysteine desulfhydrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDRKVVYMDYSATTYTKPEVLEEMLPYFTGKFGNPSSKFYSVSQDPIEAIDSARERVAKGINSEKDEIYFTSGGSEADNW
AIKGVAFANKNKGNHIITTAIEHHAVLHSCEFLKRNGFEITYLPVNDEGLISLEDLKNAIKDNTILVTIMFANNEIGAIQ
SIKEIGKICRERKVLFHTDAVQAMGHVPIDVKDMNIDMLSMAGHKFYGPKGIGALYIRKGVRIENLIHGGGQEKGKRGTT
ENVPGIVGIGKAIELATEHLYEEKERLTKMRDRLIEGLMNKIPHTKLNGPTGDKRLPNNVNLSFIGIEGETLLLDLDFEG
VCASTGSACASGSLDPSHVLLSIGLSHGIAHGSLRLTLGEGSTEEDVDYILNTLPDIVKRRREMSPYWEDYLKSLKEGEK

Sequences:

>Translated_400_residues
MDRKVVYMDYSATTYTKPEVLEEMLPYFTGKFGNPSSKFYSVSQDPIEAIDSARERVAKGINSEKDEIYFTSGGSEADNW
AIKGVAFANKNKGNHIITTAIEHHAVLHSCEFLKRNGFEITYLPVNDEGLISLEDLKNAIKDNTILVTIMFANNEIGAIQ
SIKEIGKICRERKVLFHTDAVQAMGHVPIDVKDMNIDMLSMAGHKFYGPKGIGALYIRKGVRIENLIHGGGQEKGKRGTT
ENVPGIVGIGKAIELATEHLYEEKERLTKMRDRLIEGLMNKIPHTKLNGPTGDKRLPNNVNLSFIGIEGETLLLDLDFEG
VCASTGSACASGSLDPSHVLLSIGLSHGIAHGSLRLTLGEGSTEEDVDYILNTLPDIVKRRREMSPYWEDYLKSLKEGEK
>Mature_400_residues
MDRKVVYMDYSATTYTKPEVLEEMLPYFTGKFGNPSSKFYSVSQDPIEAIDSARERVAKGINSEKDEIYFTSGGSEADNW
AIKGVAFANKNKGNHIITTAIEHHAVLHSCEFLKRNGFEITYLPVNDEGLISLEDLKNAIKDNTILVTIMFANNEIGAIQ
SIKEIGKICRERKVLFHTDAVQAMGHVPIDVKDMNIDMLSMAGHKFYGPKGIGALYIRKGVRIENLIHGGGQEKGKRGTT
ENVPGIVGIGKAIELATEHLYEEKERLTKMRDRLIEGLMNKIPHTKLNGPTGDKRLPNNVNLSFIGIEGETLLLDLDFEG
VCASTGSACASGSLDPSHVLLSIGLSHGIAHGSLRLTLGEGSTEEDVDYILNTLPDIVKRRREMSPYWEDYLKSLKEGEK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=47.4226804123711, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI156713448, Length=417, Percent_Identity=37.410071942446, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI48994898, Length=390, Percent_Identity=46.1538461538462, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1789175, Length=389, Percent_Identity=24.9357326478149, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787970, Length=309, Percent_Identity=25.8899676375405, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=389, Percent_Identity=45.7583547557841, Blast_Score=347, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17533177, Length=322, Percent_Identity=31.6770186335404, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319831, Length=388, Percent_Identity=47.1649484536082, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI20129463, Length=390, Percent_Identity=46.6666666666667, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44242; Mature: 44242

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKVVYMDYSATTYTKPEVLEEMLPYFTGKFGNPSSKFYSVSQDPIEAIDSARERVAKG
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
INSEKDEIYFTSGGSEADNWAIKGVAFANKNKGNHIITTAIEHHAVLHSCEFLKRNGFEI
CCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEE
TYLPVNDEGLISLEDLKNAIKDNTILVTIMFANNEIGAIQSIKEIGKICRERKVLFHTDA
EEEEECCCCCEEHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEHH
VQAMGHVPIDVKDMNIDMLSMAGHKFYGPKGIGALYIRKGVRIENLIHGGGQEKGKRGTT
HHHHCCCCEEEEECCEEEEHHCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCCCCCC
ENVPGIVGIGKAIELATEHLYEEKERLTKMRDRLIEGLMNKIPHTKLNGPTGDKRLPNNV
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NLSFIGIEGETLLLDLDFEGVCASTGSACASGSLDPSHVLLSIGLSHGIAHGSLRLTLGE
CEEEEEECCCEEEEEECCCCCCCCCCCHHCCCCCCHHHHHEEEHHHHCCCCCEEEEEECC
GSTEEDVDYILNTLPDIVKRRREMSPYWEDYLKSLKEGEK
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDRKVVYMDYSATTYTKPEVLEEMLPYFTGKFGNPSSKFYSVSQDPIEAIDSARERVAKG
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
INSEKDEIYFTSGGSEADNWAIKGVAFANKNKGNHIITTAIEHHAVLHSCEFLKRNGFEI
CCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEE
TYLPVNDEGLISLEDLKNAIKDNTILVTIMFANNEIGAIQSIKEIGKICRERKVLFHTDA
EEEEECCCCCEEHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEHH
VQAMGHVPIDVKDMNIDMLSMAGHKFYGPKGIGALYIRKGVRIENLIHGGGQEKGKRGTT
HHHHCCCCEEEEECCEEEEHHCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCCCCCC
ENVPGIVGIGKAIELATEHLYEEKERLTKMRDRLIEGLMNKIPHTKLNGPTGDKRLPNNV
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NLSFIGIEGETLLLDLDFEGVCASTGSACASGSLDPSHVLLSIGLSHGIAHGSLRLTLGE
CEEEEEECCCEEEEEECCCCCCCCCCCHHCCCCCCHHHHHEEEHHHHCCCCCEEEEEECC
GSTEEDVDYILNTLPDIVKRRREMSPYWEDYLKSLKEGEK
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA