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The map label for this gene is yqgN [H]

Identifier: 28210716

GI number: 28210716

Start: 1080834

End: 1081385

Strand: Direct

Name: yqgN [H]

Synonym: CTC01011

Alternate gene names: 28210716

Gene position: 1080834-1081385 (Clockwise)

Preceding gene: 28210715

Following gene: 28210717

Centisome position: 38.61

GC content: 27.54

Gene sequence:

>552_bases
ATGATTGATAAAAAAGAACTAAGGGAAAAGAGTATGGTAAAAAGAGATGGTTTATCTAAAGATAAAATAAATGAATATGA
TGGAAATATATTTGAAAGAGTTATAGAAAGTAAATATTACAAAGAAGCAAATTGTATATTTATATTTGTGAGTTATAAAT
CAGAAGTACATACTCATGAAATTATAAAAAGAGCCCTAAAAGATAATAAAAGAGTATGTGTACCTAAAATAATATCTTTA
AAAGATGGAATGGAAGTAATAGAAATAAAGAGTTTTTCAGAATTGAAGCCAGGGGAAAAAGGAATATTAGAGCCTGTAGA
TTTTTCTCGAAAAGTAGATCCTATGGAAATAGATATAGTTTTCACACCGGGATTAGCTTTTGATAATAAAGGGGGAAGAC
TAGGATATGGAGGGGGCTTTTATGATAAGTTTTTTAAAAGACTTAAAAAAGATACTCCTAAAGTTGGGTTAGCCTATTCT
TTTCAAATTGTAGATTTTGTACCTATGTATGAATGGGATGTAAGAATTAATGATATAATAGTAAATGAGTAA

Upstream 100 bases:

>100_bases
CAGATATAATCTAAATTCTAATAGTAGCCCAGTAGACACCATAGGAGCTAGAATGAAAGAAGAGAATCTCAAGAATAAAT
AAAAGTTAGGATGAAGTAGC

Downstream 100 bases:

>100_bases
ATTTAAACCTAAATATATAAATGGAGGTGAATACTCTAATTAATTAGAGTGCGGATATGAAACAAAATATTTTAGAAAAA
AAATATAATTATGTTTGGAA

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MIDKKELREKSMVKRDGLSKDKINEYDGNIFERVIESKYYKEANCIFIFVSYKSEVHTHEIIKRALKDNKRVCVPKIISL
KDGMEVIEIKSFSELKPGEKGILEPVDFSRKVDPMEIDIVFTPGLAFDNKGGRLGYGGGFYDKFFKRLKKDTPKVGLAYS
FQIVDFVPMYEWDVRINDIIVNE

Sequences:

>Translated_183_residues
MIDKKELREKSMVKRDGLSKDKINEYDGNIFERVIESKYYKEANCIFIFVSYKSEVHTHEIIKRALKDNKRVCVPKIISL
KDGMEVIEIKSFSELKPGEKGILEPVDFSRKVDPMEIDIVFTPGLAFDNKGGRLGYGGGFYDKFFKRLKKDTPKVGLAYS
FQIVDFVPMYEWDVRINDIIVNE
>Mature_183_residues
MIDKKELREKSMVKRDGLSKDKINEYDGNIFERVIESKYYKEANCIFIFVSYKSEVHTHEIIKRALKDNKRVCVPKIISL
KDGMEVIEIKSFSELKPGEKGILEPVDFSRKVDPMEIDIVFTPGLAFDNKGGRLGYGGGFYDKFFKRLKKDTPKVGLAYS
FQIVDFVPMYEWDVRINDIIVNE

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=188, Percent_Identity=27.1276595744681, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1789278, Length=171, Percent_Identity=29.2397660818713, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17510857, Length=188, Percent_Identity=30.3191489361702, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI161077430, Length=179, Percent_Identity=27.3743016759777, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 21262; Mature: 21262

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKKELREKSMVKRDGLSKDKINEYDGNIFERVIESKYYKEANCIFIFVSYKSEVHTHE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHH
IIKRALKDNKRVCVPKIISLKDGMEVIEIKSFSELKPGEKGILEPVDFSRKVDPMEIDIV
HHHHHHHCCCCEECCEEEECCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCCCEEEEEE
FTPGLAFDNKGGRLGYGGGFYDKFFKRLKKDTPKVGLAYSFQIVDFVPMYEWDVRINDII
EECCEEECCCCCEECCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEECEEEEEEE
VNE
ECC
>Mature Secondary Structure
MIDKKELREKSMVKRDGLSKDKINEYDGNIFERVIESKYYKEANCIFIFVSYKSEVHTHE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHH
IIKRALKDNKRVCVPKIISLKDGMEVIEIKSFSELKPGEKGILEPVDFSRKVDPMEIDIV
HHHHHHHCCCCEECCEEEECCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCCCEEEEEE
FTPGLAFDNKGGRLGYGGGFYDKFFKRLKKDTPKVGLAYSFQIVDFVPMYEWDVRINDII
EECCEEECCCCCEECCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEECEEEEEEE
VNE
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]