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The map label for this gene is yyaL [H]

Identifier: 28210673

GI number: 28210673

Start: 1028996

End: 1031137

Strand: Direct

Name: yyaL [H]

Synonym: CTC00965

Alternate gene names: 28210673

Gene position: 1028996-1031137 (Clockwise)

Preceding gene: 28210672

Following gene: 28210674

Centisome position: 36.76

GC content: 28.85

Gene sequence:

>2142_bases
TTGAGGAATATTTTTAACCTATTGGTATTAGCAGCTTTTAAAATTTATAGTATCTTTTTTATTTTAGGGTATAATAACAT
AAAACAACTTATAAAAGGAAGTGATAGTATGACTAACTCAAATAGAGTACCAAATAGATTAGCTCAAGAAAAAAGTCCGT
ATCTATTACAACATGCCTATAATCCTGTAGATTGGTATCCATGGGGAGAAGAAGCTTTCCAAAAAGCAAAAGAAGAAGAT
AAACCAATATTTTTAAGCATAGGTTACTCTACATGCCATTGGTGCCATGTAATGGAGAGAGAATCTTTTGAAGATGAAGA
AGTAGCTAAAGTATTAAATGATAATTTTATTTCTATAAAAGTTGATAGAGAGGAAAGACCAGATATTGATAATATATACA
TGACCTTCTGTCAGGCAGTTACAGGAAGTGGAGGGTGGCCTTTAACTATAATAATGACTCCTGATAAAAAGCCTTTCTTT
GCTGGAACTTATTTTCCTAAGGAAGATAGATATGGAGTAAGGGGACTTATGTATATTTTAAAAGAAATGAGTAATCAATG
GAAGAATAATAGAGAACTCATATTAAATTCCTCTGAAAAACTATTAAAAGATATGAGTCAATATATATCAGTATCACAAA
GGGAAGATTTAAATAAAGAAGTTATAAAGGAATGTTTTGAAGTATTAAAGGAAAGCTATGATCCTATACACGGAGGATTT
TATGATGCACCTAAATTTCCTACAAGTCATAAACTTATGTTCCTTTTAAGATACTATAGATTATACAAAGATGAAGAGGC
TTTAAATATAGTAGAAAAAACTCTTAAATCTATGTATAAAGGTGGAATATTTGACCATATAGGATATGGTTTTTCTAGAT
ATTCTACAGATGATAAATGGTTAGTTCCCCATTTTGAAAAAATGTTATATGATAACGCAATGCTTACAATAGCTTATGCT
GAAATGTATCAAATAACTAAAGAGGAGTTATACAAAGAAATAATAGAAAAAACAATTTCTTACGTAATAAGAGATATGAA
AGATAAAAAAGGAGCTTTTTATTCAGCAGAAGATGCGGATTCAGAAGGAGTAGAAGGCAAATTTTATGTATGGACTTTAG
AAGAGATAGAAGATATTTTAGGCAAAGAGGATGCAAAACTTTTCTCAAAATATTATGGAATAACAGATAGAGGAAACTTT
GAGGGTGAAAATATACCTAATTTAATTGAGACACCTCTAGAGGATTTAGAGCCTGATGTAAAGGATAAATTAGAAAATAT
TCGGAAGACTCTTTTTATTAATAGAGAAAAAAGAATACATCCCCATAAGGATACTAAAATACTTACTTCTTGGAATGGAT
TGATGATAGCGGCTTTAGCTTATAGTGGTAGAGTGTTAAAAAGAAAGGACTACATAGAAAGTGCAGAAGAAGCAGTAAAG
TTTATAATGAAAAATTTAATAGATGAAAATGGAAGAATATATGTTCGATATAGAGATGGTGAAAGAGCACATAAAGGGCA
TCTTGAAGACTATTCCTTTTTAATATGGGCTCTTATAGAGCTTTATCAAAGTACCTTTAAAACTGAGTATATAGAAAAGG
CATTAAAGATTAATTATGATATGATTGAATTATTCTGGGATGAAGAAAATCATGGTTTTTTCCATACTGGAAAAGATGGA
GAAGAATTAATATTAAAACTTAAGGAAAGCTATGATTCTGCTATACCATCAGGAAATTCTGTGGCTATGTATAATATGGT
AAGACTTAGTAGAATTACAGGGGATAGCAAATTAGATGAAATAATTCAACAAAATCTAAATTATTTTTCAGGAAGGATAA
AAAGCACTTTAGAATCCCATACATTCTTTTTAATATCCTATATGCATTATGTTTTAGAAAGTGAAGAGATTGTTATAGTA
AAAGGAGAAGATGAGGATATATTTAAAGCTATGATTAAAGTAATAAATGAAAAATATCATCCTTTTTCTATGAATATTGT
AAAGGATGAAAAAGTGGAAAAATTAATGCCAGAATTAAAAGAAAAAAACAATATACAAAATAAAACCACAGTATATATAT
GTAAAAACTTTGCTTGTGGTAATCCTATAATTTCACTGGAAGATTTAATAGATAAGTATTGA

Upstream 100 bases:

>100_bases
ATCCCCCGTATGGGGATATAAAGATTATAACATATTATTTGGTAAAAAGCATTTGTTTGTGTATTTTTTCACTAGAAATC
TTTGATAAATAACTTGCTGA

Downstream 100 bases:

>100_bases
CAAATATGAAAATATAACACTATAATATAGTTTAGATTAATTTATAATATAATAAAATTCTAGGAAGAGGAAAGTAACTT
TTTCTTTCTTTTTAAGCGAG

Product: thymidylate kinase

Products: ADP; dTDP

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MRNIFNLLVLAAFKIYSIFFILGYNNIKQLIKGSDSMTNSNRVPNRLAQEKSPYLLQHAYNPVDWYPWGEEAFQKAKEED
KPIFLSIGYSTCHWCHVMERESFEDEEVAKVLNDNFISIKVDREERPDIDNIYMTFCQAVTGSGGWPLTIIMTPDKKPFF
AGTYFPKEDRYGVRGLMYILKEMSNQWKNNRELILNSSEKLLKDMSQYISVSQREDLNKEVIKECFEVLKESYDPIHGGF
YDAPKFPTSHKLMFLLRYYRLYKDEEALNIVEKTLKSMYKGGIFDHIGYGFSRYSTDDKWLVPHFEKMLYDNAMLTIAYA
EMYQITKEELYKEIIEKTISYVIRDMKDKKGAFYSAEDADSEGVEGKFYVWTLEEIEDILGKEDAKLFSKYYGITDRGNF
EGENIPNLIETPLEDLEPDVKDKLENIRKTLFINREKRIHPHKDTKILTSWNGLMIAALAYSGRVLKRKDYIESAEEAVK
FIMKNLIDENGRIYVRYRDGERAHKGHLEDYSFLIWALIELYQSTFKTEYIEKALKINYDMIELFWDEENHGFFHTGKDG
EELILKLKESYDSAIPSGNSVAMYNMVRLSRITGDSKLDEIIQQNLNYFSGRIKSTLESHTFFLISYMHYVLESEEIVIV
KGEDEDIFKAMIKVINEKYHPFSMNIVKDEKVEKLMPELKEKNNIQNKTTVYICKNFACGNPIISLEDLIDKY

Sequences:

>Translated_713_residues
MRNIFNLLVLAAFKIYSIFFILGYNNIKQLIKGSDSMTNSNRVPNRLAQEKSPYLLQHAYNPVDWYPWGEEAFQKAKEED
KPIFLSIGYSTCHWCHVMERESFEDEEVAKVLNDNFISIKVDREERPDIDNIYMTFCQAVTGSGGWPLTIIMTPDKKPFF
AGTYFPKEDRYGVRGLMYILKEMSNQWKNNRELILNSSEKLLKDMSQYISVSQREDLNKEVIKECFEVLKESYDPIHGGF
YDAPKFPTSHKLMFLLRYYRLYKDEEALNIVEKTLKSMYKGGIFDHIGYGFSRYSTDDKWLVPHFEKMLYDNAMLTIAYA
EMYQITKEELYKEIIEKTISYVIRDMKDKKGAFYSAEDADSEGVEGKFYVWTLEEIEDILGKEDAKLFSKYYGITDRGNF
EGENIPNLIETPLEDLEPDVKDKLENIRKTLFINREKRIHPHKDTKILTSWNGLMIAALAYSGRVLKRKDYIESAEEAVK
FIMKNLIDENGRIYVRYRDGERAHKGHLEDYSFLIWALIELYQSTFKTEYIEKALKINYDMIELFWDEENHGFFHTGKDG
EELILKLKESYDSAIPSGNSVAMYNMVRLSRITGDSKLDEIIQQNLNYFSGRIKSTLESHTFFLISYMHYVLESEEIVIV
KGEDEDIFKAMIKVINEKYHPFSMNIVKDEKVEKLMPELKEKNNIQNKTTVYICKNFACGNPIISLEDLIDKY
>Mature_713_residues
MRNIFNLLVLAAFKIYSIFFILGYNNIKQLIKGSDSMTNSNRVPNRLAQEKSPYLLQHAYNPVDWYPWGEEAFQKAKEED
KPIFLSIGYSTCHWCHVMERESFEDEEVAKVLNDNFISIKVDREERPDIDNIYMTFCQAVTGSGGWPLTIIMTPDKKPFF
AGTYFPKEDRYGVRGLMYILKEMSNQWKNNRELILNSSEKLLKDMSQYISVSQREDLNKEVIKECFEVLKESYDPIHGGF
YDAPKFPTSHKLMFLLRYYRLYKDEEALNIVEKTLKSMYKGGIFDHIGYGFSRYSTDDKWLVPHFEKMLYDNAMLTIAYA
EMYQITKEELYKEIIEKTISYVIRDMKDKKGAFYSAEDADSEGVEGKFYVWTLEEIEDILGKEDAKLFSKYYGITDRGNF
EGENIPNLIETPLEDLEPDVKDKLENIRKTLFINREKRIHPHKDTKILTSWNGLMIAALAYSGRVLKRKDYIESAEEAVK
FIMKNLIDENGRIYVRYRDGERAHKGHLEDYSFLIWALIELYQSTFKTEYIEKALKINYDMIELFWDEENHGFFHTGKDG
EELILKLKESYDSAIPSGNSVAMYNMVRLSRITGDSKLDEIIQQNLNYFSGRIKSTLESHTFFLISYMHYVLESEEIVIV
KGEDEDIFKAMIKVINEKYHPFSMNIVKDEKVEKLMPELKEKNNIQNKTTVYICKNFACGNPIISLEDLIDKY

Specific function: Unknown

COG id: COG1331

COG function: function code O; Highly conserved protein containing a thioredoxin domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To C.elegans B0495.5 [H]

Homologues:

Organism=Homo sapiens, GI31542723, Length=727, Percent_Identity=39.2022008253095, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25147430, Length=710, Percent_Identity=36.6197183098592, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI20129985, Length=730, Percent_Identity=37.5342465753425, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR012341
- InterPro:   IPR010819
- InterPro:   IPR004879
- InterPro:   IPR005198
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03190 DUF255; PF07221 GlcNAc_2-epim; PF03663 Glyco_hydro_76 [H]

EC number: 2.7.4.9

Molecular weight: Translated: 83743; Mature: 83743

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIFNLLVLAAFKIYSIFFILGYNNIKQLIKGSDSMTNSNRVPNRLAQEKSPYLLQHAY
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHCC
NPVDWYPWGEEAFQKAKEEDKPIFLSIGYSTCHWCHVMERESFEDEEVAKVLNDNFISIK
CCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCEEEEE
VDREERPDIDNIYMTFCQAVTGSGGWPLTIIMTPDKKPFFAGTYFPKEDRYGVRGLMYIL
ECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHH
KEMSNQWKNNRELILNSSEKLLKDMSQYISVSQREDLNKEVIKECFEVLKESYDPIHGGF
HHHHHHCCCCCEEEECCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
YDAPKFPTSHKLMFLLRYYRLYKDEEALNIVEKTLKSMYKGGIFDHIGYGFSRYSTDDKW
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCE
LVPHFEKMLYDNAMLTIAYAEMYQITKEELYKEIIEKTISYVIRDMKDKKGAFYSAEDAD
EHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
SEGVEGKFYVWTLEEIEDILGKEDAKLFSKYYGITDRGNFEGENIPNLIETPLEDLEPDV
CCCCCCEEEEEEHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHCCCCH
KDKLENIRKTLFINREKRIHPHKDTKILTSWNGLMIAALAYSGRVLKRKDYIESAEEAVK
HHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
FIMKNLIDENGRIYVRYRDGERAHKGHLEDYSFLIWALIELYQSTFKTEYIEKALKINYD
HHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
MIELFWDEENHGFFHTGKDGEELILKLKESYDSAIPSGNSVAMYNMVRLSRITGDSKLDE
EEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCHHHHH
IIQQNLNYFSGRIKSTLESHTFFLISYMHYVLESEEIVIVKGEDEDIFKAMIKVINEKYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCC
PFSMNIVKDEKVEKLMPELKEKNNIQNKTTVYICKNFACGNPIISLEDLIDKY
CEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEHHHHHCCC
>Mature Secondary Structure
MRNIFNLLVLAAFKIYSIFFILGYNNIKQLIKGSDSMTNSNRVPNRLAQEKSPYLLQHAY
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHCC
NPVDWYPWGEEAFQKAKEEDKPIFLSIGYSTCHWCHVMERESFEDEEVAKVLNDNFISIK
CCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCEEEEE
VDREERPDIDNIYMTFCQAVTGSGGWPLTIIMTPDKKPFFAGTYFPKEDRYGVRGLMYIL
ECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHH
KEMSNQWKNNRELILNSSEKLLKDMSQYISVSQREDLNKEVIKECFEVLKESYDPIHGGF
HHHHHHCCCCCEEEECCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
YDAPKFPTSHKLMFLLRYYRLYKDEEALNIVEKTLKSMYKGGIFDHIGYGFSRYSTDDKW
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCE
LVPHFEKMLYDNAMLTIAYAEMYQITKEELYKEIIEKTISYVIRDMKDKKGAFYSAEDAD
EHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
SEGVEGKFYVWTLEEIEDILGKEDAKLFSKYYGITDRGNFEGENIPNLIETPLEDLEPDV
CCCCCCEEEEEEHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHCCCCH
KDKLENIRKTLFINREKRIHPHKDTKILTSWNGLMIAALAYSGRVLKRKDYIESAEEAVK
HHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
FIMKNLIDENGRIYVRYRDGERAHKGHLEDYSFLIWALIELYQSTFKTEYIEKALKINYD
HHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
MIELFWDEENHGFFHTGKDGEELILKLKESYDSAIPSGNSVAMYNMVRLSRITGDSKLDE
EEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCHHHHH
IIQQNLNYFSGRIKSTLESHTFFLISYMHYVLESEEIVIVKGEDEDIFKAMIKVINEKYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCC
PFSMNIVKDEKVEKLMPELKEKNNIQNKTTVYICKNFACGNPIISLEDLIDKY
CEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dTMP

Specific reaction: ATP + dTMP = ADP + dTDP

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]