Click here to switch to the map view.

The map label for this gene is panF [H]

Identifier: 28210639

GI number: 28210639

Start: 987337

End: 988797

Strand: Direct

Name: panF [H]

Synonym: CTC00928

Alternate gene names: 28210639

Gene position: 987337-988797 (Clockwise)

Preceding gene: 28210638

Following gene: 28210640

Centisome position: 35.27

GC content: 31.49

Gene sequence:

>1461_bases
ATGAATACAGGATTATTAAGTTTTTTTATAATAGTTATATATTTAGCATTAATGCTTGGAATAACAATTCATAGTTCAAG
AAAAAGTAAAGCTAGTAATGCAGAAGGATTTTTTCTTGCTAACAGAGGAGTAAACTCATTTTTACTGCCCCTTACAATGA
TAGCCGCTATGCAAAGTACATTTGCTTTTTTAGGAGCACCAGGAATGTATTATACTCATGGTATTTCATACATGGTATTA
GTTTTAAGCCAGGTATGGGTTGCACTAATGGTAATTTATTTTGGAAATAAGATATGTAAATTAGGTAAAAAATACGGATA
TATGTCCATAGGAGATTATTTTCAGGACAGATATGAGAGTGATTATTTAAAGGTATTAGCATCTTGTATATCTGTACTTA
TGACTATAGTGTTTTTATCCATGCAATATGTTGGAAATGCAAGGGCGATATCTGTTATAAGTGGTGGTATGATATCTTAT
AAGTCTGCTATATTAGTATCTGCAATATTTTCATTATTATATGTTGTAATAGGAGGAGCAAGTAGTGTAGTTTTAATAGA
TGCTATACAAGCAGTAATACTTTTAGTAGGTATGGTTTTAGCAGCAGCAGTTGCTATAGTACCAGCAGGAGGAGTTGAGA
ATCTATTTAAAACAGCAATAGAGACTACTCCGGAGTTATTATCTAGACCAGGTCCAAAGGGTTTATATAATAGTAAATAT
TGGATAATGCAGTTTATAGTTTTACCTTTTGGTATATGGTTATGTCCACATGTATGGATAAAATCATTAATGGCAAAGGA
TGAAAAAGCTTTATCAAGATCAGCTTTAAGTATACCAGTTTCACAAGTATTAATATATGGATTTGCTACATTATTTATAG
GACTAGCAGGTCATCAATTAATAGGGAAAGTAGATGCGGCAGATAACGTATTACCAATATTAATGAATAATCATGCAAAT
TGGTTTTTAGCTGCTCTTATAATGGCGGCTGCTGTAGCTGCAGGTATGTCTACAATAAACTCTATGATACTAGTTACATC
ACAAATAGTATCTCAAGATTTAATCCTTATGAAGAAAAAGGACAAGGTTACAGACAAACAAAACTTAATATTATCAAGAA
TAATAATATTGACAATAGTTATTATAGGATCATTAATAGCTCTAAGACCCCCTAAAACTTTAGTTCAGGTTGTACAGGAT
GTTGCTTATACTGGACTTGCTCAAATGGCACCAGCTTTTGTATTAGGACTATACTGGAAAAATGCAAGAAAAGAAGGGGC
AATAGTTGGAATGACTGTAGGAACAATAATATTGTTTGCAACAAGAATATTAAATGTAACACCATTAGGAATTCCAGGAT
TTTTATGGGGGTTCTTTATAAATATATTATGTTTAATGGTAATCTCCATAGCATTTAAATGCAAAGATAATACAAGAGCA
GAAGAAAGATTCTTTGCTTAA

Upstream 100 bases:

>100_bases
ATTGGTGGATACTTATGTTTGTAAACCTTATTTTTATACTTTGGGTATGTAGTTGTTTTGTAAAGAGTGCTCAAAAGGAT
AAAAAGGAGGAAGTAAAATA

Downstream 100 bases:

>100_bases
TATAAAACTAAATTTAAAGTATTGGAGGAGAATAATTTGTCGAAGATAATTTATAATAAACAACTATCAAAAGATTTTTA
TATTATGAAAGTTGAAGGAA

Product: sodium/pantothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNTGLLSFFIIVIYLALMLGITIHSSRKSKASNAEGFFLANRGVNSFLLPLTMIAAMQSTFAFLGAPGMYYTHGISYMVL
VLSQVWVALMVIYFGNKICKLGKKYGYMSIGDYFQDRYESDYLKVLASCISVLMTIVFLSMQYVGNARAISVISGGMISY
KSAILVSAIFSLLYVVIGGASSVVLIDAIQAVILLVGMVLAAAVAIVPAGGVENLFKTAIETTPELLSRPGPKGLYNSKY
WIMQFIVLPFGIWLCPHVWIKSLMAKDEKALSRSALSIPVSQVLIYGFATLFIGLAGHQLIGKVDAADNVLPILMNNHAN
WFLAALIMAAAVAAGMSTINSMILVTSQIVSQDLILMKKKDKVTDKQNLILSRIIILTIVIIGSLIALRPPKTLVQVVQD
VAYTGLAQMAPAFVLGLYWKNARKEGAIVGMTVGTIILFATRILNVTPLGIPGFLWGFFINILCLMVISIAFKCKDNTRA
EERFFA

Sequences:

>Translated_486_residues
MNTGLLSFFIIVIYLALMLGITIHSSRKSKASNAEGFFLANRGVNSFLLPLTMIAAMQSTFAFLGAPGMYYTHGISYMVL
VLSQVWVALMVIYFGNKICKLGKKYGYMSIGDYFQDRYESDYLKVLASCISVLMTIVFLSMQYVGNARAISVISGGMISY
KSAILVSAIFSLLYVVIGGASSVVLIDAIQAVILLVGMVLAAAVAIVPAGGVENLFKTAIETTPELLSRPGPKGLYNSKY
WIMQFIVLPFGIWLCPHVWIKSLMAKDEKALSRSALSIPVSQVLIYGFATLFIGLAGHQLIGKVDAADNVLPILMNNHAN
WFLAALIMAAAVAAGMSTINSMILVTSQIVSQDLILMKKKDKVTDKQNLILSRIIILTIVIIGSLIALRPPKTLVQVVQD
VAYTGLAQMAPAFVLGLYWKNARKEGAIVGMTVGTIILFATRILNVTPLGIPGFLWGFFINILCLMVISIAFKCKDNTRA
EERFFA
>Mature_486_residues
MNTGLLSFFIIVIYLALMLGITIHSSRKSKASNAEGFFLANRGVNSFLLPLTMIAAMQSTFAFLGAPGMYYTHGISYMVL
VLSQVWVALMVIYFGNKICKLGKKYGYMSIGDYFQDRYESDYLKVLASCISVLMTIVFLSMQYVGNARAISVISGGMISY
KSAILVSAIFSLLYVVIGGASSVVLIDAIQAVILLVGMVLAAAVAIVPAGGVENLFKTAIETTPELLSRPGPKGLYNSKY
WIMQFIVLPFGIWLCPHVWIKSLMAKDEKALSRSALSIPVSQVLIYGFATLFIGLAGHQLIGKVDAADNVLPILMNNHAN
WFLAALIMAAAVAAGMSTINSMILVTSQIVSQDLILMKKKDKVTDKQNLILSRIIILTIVIIGSLIALRPPKTLVQVVQD
VAYTGLAQMAPAFVLGLYWKNARKEGAIVGMTVGTIILFATRILNVTPLGIPGFLWGFFINILCLMVISIAFKCKDNTRA
EERFFA

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=513, Percent_Identity=26.1208576998051, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI14140236, Length=470, Percent_Identity=20.2127659574468, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI109659836, Length=492, Percent_Identity=22.9674796747967, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082237, Length=446, Percent_Identity=29.5964125560538, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787251, Length=477, Percent_Identity=23.6897274633124, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790503, Length=455, Percent_Identity=23.2967032967033, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790113, Length=397, Percent_Identity=22.9219143576826, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52910; Mature: 52910

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTGLLSFFIIVIYLALMLGITIHSSRKSKASNAEGFFLANRGVNSFLLPLTMIAAMQST
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
FAFLGAPGMYYTHGISYMVLVLSQVWVALMVIYFGNKICKLGKKYGYMSIGDYFQDRYES
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCH
DYLKVLASCISVLMTIVFLSMQYVGNARAISVISGGMISYKSAILVSAIFSLLYVVIGGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SSVVLIDAIQAVILLVGMVLAAAVAIVPAGGVENLFKTAIETTPELLSRPGPKGLYNSKY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCHH
WIMQFIVLPFGIWLCPHVWIKSLMAKDEKALSRSALSIPVSQVLIYGFATLFIGLAGHQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IGKVDAADNVLPILMNNHANWFLAALIMAAAVAAGMSTINSMILVTSQIVSQDLILMKKK
HHCCCCCCCEEEHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DKVTDKQNLILSRIIILTIVIIGSLIALRPPKTLVQVVQDVAYTGLAQMAPAFVLGLYWK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NARKEGAIVGMTVGTIILFATRILNVTPLGIPGFLWGFFINILCLMVISIAFKCKDNTRA
CCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EERFFA
HHHCCC
>Mature Secondary Structure
MNTGLLSFFIIVIYLALMLGITIHSSRKSKASNAEGFFLANRGVNSFLLPLTMIAAMQST
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
FAFLGAPGMYYTHGISYMVLVLSQVWVALMVIYFGNKICKLGKKYGYMSIGDYFQDRYES
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCH
DYLKVLASCISVLMTIVFLSMQYVGNARAISVISGGMISYKSAILVSAIFSLLYVVIGGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
SSVVLIDAIQAVILLVGMVLAAAVAIVPAGGVENLFKTAIETTPELLSRPGPKGLYNSKY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCHH
WIMQFIVLPFGIWLCPHVWIKSLMAKDEKALSRSALSIPVSQVLIYGFATLFIGLAGHQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IGKVDAADNVLPILMNNHANWFLAALIMAAAVAAGMSTINSMILVTSQIVSQDLILMKKK
HHCCCCCCCEEEHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DKVTDKQNLILSRIIILTIVIIGSLIALRPPKTLVQVVQDVAYTGLAQMAPAFVLGLYWK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NARKEGAIVGMTVGTIILFATRILNVTPLGIPGFLWGFFINILCLMVISIAFKCKDNTRA
CCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EERFFA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]