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The map label for this gene is pyrC [H]

Identifier: 28210638

GI number: 28210638

Start: 985778

End: 987043

Strand: Direct

Name: pyrC [H]

Synonym: CTC00927

Alternate gene names: 28210638

Gene position: 985778-987043 (Clockwise)

Preceding gene: 28210637

Following gene: 28210639

Centisome position: 35.22

GC content: 30.88

Gene sequence:

>1266_bases
ATGATACTTATTAAAGATGGTAGATTAATAGATCCTAAAACTAATAAAGATGAAATTTTAGATTTAATTATTAAAGATAA
TAAAATTTATAAGATAGGTAAGTTTCAATCAAGTGATAAGTATGAAACTGTTATAGATGCAAAAGGAAAAATAGTGGCAC
CAGGATTAATTGATGTTCATGTACACTTTAGAGACCCAGGCTTTACTTATAAGGAAGATATACAAACGGGTTCTGATTCA
GCAGCAAGAGGTGGATTTACTACTGTTGTTTGTATGGCAAATACTAATCCTATAGTGGACAATGAAGAAACCCTTAATTA
CATAAAAAAAGAGAGTGAAAAATCTAAAATAAATGTATTGCAAGTAGGAGCAATAACAAAAGGATTTAAAGGAAAAGAAT
TAGTAGATATGGAGTATTTAAAATCAATAGGTGCTGTTGGATTTAGTGATGATGGAGTTCCAATAATGGATAGCAAATTA
GTTATGGAAGCTATGATTAAAGCTAAAGAACTTAACGTACCATTAAGTTTTCACGAAGAGGATCCTGCATTAATTGGAAG
TTCTGGAATAAATCAAGGAAAAATATCAGATAAACTTTGTGGTAAAGGAGCACCTAATGTAGCTGAGGATACTATGGTAG
CAAGAGACTGTATATTAGCTTTAAAAACCGGAGCAAAAGTAAATATACAGCATATAAGTTCGGGGATATCCGTGGACATC
GTAAGATTTGTTAAATCTTTAGGAGCTAATGTAGTGGCAGAAGCTACTCCTCACCATTTTTCATTAACTGAAGAAGCAGT
ATTAGAGCATAAGACTTATGCTAAAATGAATCCTCCACTTAGGACTGAGGAAGATAAGTATAAAATAATACAGGGGTTAA
AAGATGACATTATAGAAATAATAGCTACAGATCATGCTCCTCATAGTATAGAAGAAAAAGAAAAAGAGTTAACAAAAGCT
CCTAGTGGAATAATAGGGCTTGAAACATCCTTAGCATTAGGTATATCTAATTTAGTTAGAAAAGGACATCTTACTATAAT
GAAATTAATAGAGAAAATGACTATAAATCCAGCTAAATTATATAACTTAGACACAGGATTTATTGCTGAAGGAGCAATTG
CAGATATAGTAATATTTGATCCATCAGAAAATTGGGTGGTTTCAGGTTTTGCCTCAAAATCTTCAAATTCTCCTTTTAAG
GGACAAAATCTTTATGGAAAAATAAAATATACCATATGTAAAGGAAATATAGTTTACAAAGATTAA

Upstream 100 bases:

>100_bases
CTAAGGGCATAAGTCATAATAAAAATGAGTTCACGTCTTTAGAGAGCATTCTTGATGGAACCAAAGTTATGTATGAATAT
TTGAAGGGAGAAATATATAA

Downstream 100 bases:

>100_bases
GGATGAATTAAAAATGTTATAAAAATCAAAATATTTTTAAAGAATTATTTTATCTTAAAAAGGGGGAAAAATATGAATAA
TAAATTAATATTAAGCATAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MILIKDGRLIDPKTNKDEILDLIIKDNKIYKIGKFQSSDKYETVIDAKGKIVAPGLIDVHVHFRDPGFTYKEDIQTGSDS
AARGGFTTVVCMANTNPIVDNEETLNYIKKESEKSKINVLQVGAITKGFKGKELVDMEYLKSIGAVGFSDDGVPIMDSKL
VMEAMIKAKELNVPLSFHEEDPALIGSSGINQGKISDKLCGKGAPNVAEDTMVARDCILALKTGAKVNIQHISSGISVDI
VRFVKSLGANVVAEATPHHFSLTEEAVLEHKTYAKMNPPLRTEEDKYKIIQGLKDDIIEIIATDHAPHSIEEKEKELTKA
PSGIIGLETSLALGISNLVRKGHLTIMKLIEKMTINPAKLYNLDTGFIAEGAIADIVIFDPSENWVVSGFASKSSNSPFK
GQNLYGKIKYTICKGNIVYKD

Sequences:

>Translated_421_residues
MILIKDGRLIDPKTNKDEILDLIIKDNKIYKIGKFQSSDKYETVIDAKGKIVAPGLIDVHVHFRDPGFTYKEDIQTGSDS
AARGGFTTVVCMANTNPIVDNEETLNYIKKESEKSKINVLQVGAITKGFKGKELVDMEYLKSIGAVGFSDDGVPIMDSKL
VMEAMIKAKELNVPLSFHEEDPALIGSSGINQGKISDKLCGKGAPNVAEDTMVARDCILALKTGAKVNIQHISSGISVDI
VRFVKSLGANVVAEATPHHFSLTEEAVLEHKTYAKMNPPLRTEEDKYKIIQGLKDDIIEIIATDHAPHSIEEKEKELTKA
PSGIIGLETSLALGISNLVRKGHLTIMKLIEKMTINPAKLYNLDTGFIAEGAIADIVIFDPSENWVVSGFASKSSNSPFK
GQNLYGKIKYTICKGNIVYKD
>Mature_421_residues
MILIKDGRLIDPKTNKDEILDLIIKDNKIYKIGKFQSSDKYETVIDAKGKIVAPGLIDVHVHFRDPGFTYKEDIQTGSDS
AARGGFTTVVCMANTNPIVDNEETLNYIKKESEKSKINVLQVGAITKGFKGKELVDMEYLKSIGAVGFSDDGVPIMDSKL
VMEAMIKAKELNVPLSFHEEDPALIGSSGINQGKISDKLCGKGAPNVAEDTMVARDCILALKTGAKVNIQHISSGISVDI
VRFVKSLGANVVAEATPHHFSLTEEAVLEHKTYAKMNPPLRTEEDKYKIIQGLKDDIIEIIATDHAPHSIEEKEKELTKA
PSGIIGLETSLALGISNLVRKGHLTIMKLIEKMTINPAKLYNLDTGFIAEGAIADIVIFDPSENWVVSGFASKSSNSPFK
GQNLYGKIKYTICKGNIVYKD

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=26.8229166666667, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=25.1111111111111, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503051, Length=452, Percent_Identity=26.3274336283186, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI62422571, Length=452, Percent_Identity=26.3274336283186, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786722, Length=439, Percent_Identity=27.7904328018223, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082175, Length=444, Percent_Identity=25.6756756756757, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193204318, Length=396, Percent_Identity=29.040404040404, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI86575075, Length=439, Percent_Identity=25.9681093394077, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=404, Percent_Identity=26.4851485148515, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24642586, Length=374, Percent_Identity=29.6791443850267, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18859883, Length=475, Percent_Identity=24.2105263157895, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137462, Length=450, Percent_Identity=23.7777777777778, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46022; Mature: 46022

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIKDGRLIDPKTNKDEILDLIIKDNKIYKIGKFQSSDKYETVIDAKGKIVAPGLIDVH
CEEECCCEEECCCCCHHHEEEEEECCCEEEEEECCCCCCCCEEEECCCCCEECCCEEEEE
VHFRDPGFTYKEDIQTGSDSAARGGFTTVVCMANTNPIVDNEETLNYIKKESEKSKINVL
EEEECCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEE
QVGAITKGFKGKELVDMEYLKSIGAVGFSDDGVPIMDSKLVMEAMIKAKELNVPLSFHEE
EECCCCCCCCCCEEECHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEECCC
DPALIGSSGINQGKISDKLCGKGAPNVAEDTMVARDCILALKTGAKVNIQHISSGISVDI
CCCEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCHHH
VRFVKSLGANVVAEATPHHFSLTEEAVLEHKTYAKMNPPLRTEEDKYKIIQGLKDDIIEI
HHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IATDHAPHSIEEKEKELTKAPSGIIGLETSLALGISNLVRKGHLTIMKLIEKMTINPAKL
HCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHE
YNLDTGFIAEGAIADIVIFDPSENWVVSGFASKSSNSPFKGQNLYGKIKYTICKGNIVYK
EECCCCCEECCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEECEEEEC
D
C
>Mature Secondary Structure
MILIKDGRLIDPKTNKDEILDLIIKDNKIYKIGKFQSSDKYETVIDAKGKIVAPGLIDVH
CEEECCCEEECCCCCHHHEEEEEECCCEEEEEECCCCCCCCEEEECCCCCEECCCEEEEE
VHFRDPGFTYKEDIQTGSDSAARGGFTTVVCMANTNPIVDNEETLNYIKKESEKSKINVL
EEEECCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEE
QVGAITKGFKGKELVDMEYLKSIGAVGFSDDGVPIMDSKLVMEAMIKAKELNVPLSFHEE
EECCCCCCCCCCEEECHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEECCC
DPALIGSSGINQGKISDKLCGKGAPNVAEDTMVARDCILALKTGAKVNIQHISSGISVDI
CCCEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCHHH
VRFVKSLGANVVAEATPHHFSLTEEAVLEHKTYAKMNPPLRTEEDKYKIIQGLKDDIIEI
HHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IATDHAPHSIEEKEKELTKAPSGIIGLETSLALGISNLVRKGHLTIMKLIEKMTINPAKL
HCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHE
YNLDTGFIAEGAIADIVIFDPSENWVVSGFASKSSNSPFKGQNLYGKIKYTICKGNIVYK
EECCCCCEECCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEECEEEEC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA