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The map label for this gene is vanR [H]

Identifier: 28210522

GI number: 28210522

Start: 849627

End: 850328

Strand: Direct

Name: vanR [H]

Synonym: CTC00805

Alternate gene names: 28210522

Gene position: 849627-850328 (Clockwise)

Preceding gene: 28210515

Following gene: 28210523

Centisome position: 30.35

GC content: 27.78

Gene sequence:

>702_bases
GTGAATAAAAATACTATCATTGTAGTAGATGATGAAAAAGAAATAAGGGACTTAATATGTATATATTTAGAAAATGAAGG
CTATAGAGTAATTAAAGCAGAAAATGGTATAAAAGCATTAGAATTATTAGAGAAAGAAAAGGTAGATTTAATAATACTTG
ATATAATGATGCCAAATATGGATGGAATTGAAGCATGTACTAAAATTAGAGAAGAAAAAAACATGCCTATAATAATGTTA
TCAGCTAAAACAGAAGATATGGATAAAATATGGGGACTTACTGCAGGAGCAGATGACTATATGACAAAACCATTTAACCC
TTTAGAACTTATAGCAAGGGTAAAATCTCAATTAAGAAGATATAAAAAGTTTAATGTTCAAAATGGTTATATTAATGATG
ATATAATAGAAATAGATGAACTTACAATTAATACCGCAACCCACGAGGTTCAGGTTGGAGAAAAAAAAGTTAGACTTACT
CCTAGAGAGTTTGATATATTAGAATTACTAGCTAGAAATAAAGGAATAGTATTTAGTATAGAAAAAATATATGAAAGAGT
TTGGAAAGAAGAGTTTTTTAAATCAGATAATACAGTTATGGTACACATAAGAAAACTAAGAGAAAAGATAGAGGAAAATC
CTAGAAAACCTAAGTATGTAAAGACTGTATGGGGTGTAGGCTATAAGGTAGAAAAGTTATAA

Upstream 100 bases:

>100_bases
TCAACGGATTAAGAAAATATTAAGAATAAAATTAGTAAATTATTATAAATTTATGATATTATAAAGGTTATAGGGAGTAT
GAATGAGGAGTTGAAAAGTA

Downstream 100 bases:

>100_bases
AATTAAAGAGGTAAATATGATAAGAAAATTGATAAAATTTATATGGAGAGTTATTACCAAACCTTTTAGATATATATTTG
GTAAAATAGGTATTAGATTA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MNKNTIIVVDDEKEIRDLICIYLENEGYRVIKAENGIKALELLEKEKVDLIILDIMMPNMDGIEACTKIREEKNMPIIML
SAKTEDMDKIWGLTAGADDYMTKPFNPLELIARVKSQLRRYKKFNVQNGYINDDIIEIDELTINTATHEVQVGEKKVRLT
PREFDILELLARNKGIVFSIEKIYERVWKEEFFKSDNTVMVHIRKLREKIEENPRKPKYVKTVWGVGYKVEKL

Sequences:

>Translated_233_residues
MNKNTIIVVDDEKEIRDLICIYLENEGYRVIKAENGIKALELLEKEKVDLIILDIMMPNMDGIEACTKIREEKNMPIIML
SAKTEDMDKIWGLTAGADDYMTKPFNPLELIARVKSQLRRYKKFNVQNGYINDDIIEIDELTINTATHEVQVGEKKVRLT
PREFDILELLARNKGIVFSIEKIYERVWKEEFFKSDNTVMVHIRKLREKIEENPRKPKYVKTVWGVGYKVEKL
>Mature_233_residues
MNKNTIIVVDDEKEIRDLICIYLENEGYRVIKAENGIKALELLEKEKVDLIILDIMMPNMDGIEACTKIREEKNMPIIML
SAKTEDMDKIWGLTAGADDYMTKPFNPLELIARVKSQLRRYKKFNVQNGYINDDIIEIDELTINTATHEVQVGEKKVRLT
PREFDILELLARNKGIVFSIEKIYERVWKEEFFKSDNTVMVHIRKLREKIEENPRKPKYVKTVWGVGYKVEKL

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=36.5638766519824, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=36.6071428571429, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=35.3982300884956, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790860, Length=234, Percent_Identity=32.4786324786325, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=34.375, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=35.8407079646018, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=33.920704845815, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=30.9322033898305, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=31.6964285714286, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=28.9473684210526, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=31.140350877193, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=29.646017699115, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=30, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=36.5853658536585, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=32.8671328671329, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=159, Percent_Identity=29.559748427673, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=173, Percent_Identity=30.635838150289, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=35, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=34, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=101, Percent_Identity=33.6633663366337, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27353; Mature: 27353

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNTIIVVDDEKEIRDLICIYLENEGYRVIKAENGIKALELLEKEKVDLIILDIMMPNM
CCCCEEEEEECCHHHCEEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCC
DGIEACTKIREEKNMPIIMLSAKTEDMDKIWGLTAGADDYMTKPFNPLELIARVKSQLRR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YKKFNVQNGYINDDIIEIDELTINTATHEVQVGEKKVRLTPREFDILELLARNKGIVFSI
HHHCCCCCCCCCCCEEEEEEEEEECCCEEEEECCEEEEECCCHHHHHHHHHCCCCEEEEH
EKIYERVWKEEFFKSDNTVMVHIRKLREKIEENPRKPKYVKTVWGVGYKVEKL
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHCCCEEEECC
>Mature Secondary Structure
MNKNTIIVVDDEKEIRDLICIYLENEGYRVIKAENGIKALELLEKEKVDLIILDIMMPNM
CCCCEEEEEECCHHHCEEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCC
DGIEACTKIREEKNMPIIMLSAKTEDMDKIWGLTAGADDYMTKPFNPLELIARVKSQLRR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YKKFNVQNGYINDDIIEIDELTINTATHEVQVGEKKVRLTPREFDILELLARNKGIVFSI
HHHCCCCCCCCCCCEEEEEEEEEECCCEEEEECCEEEEECCCHHHHHHHHHCCCCEEEEH
EKIYERVWKEEFFKSDNTVMVHIRKLREKIEENPRKPKYVKTVWGVGYKVEKL
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]