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The map label for this gene is cbiC [H]

Identifier: 28210453

GI number: 28210453

Start: 758813

End: 759469

Strand: Direct

Name: cbiC [H]

Synonym: CTC00732

Alternate gene names: 28210453

Gene position: 758813-759469 (Clockwise)

Preceding gene: 28210452

Following gene: 28210454

Centisome position: 27.11

GC content: 30.9

Gene sequence:

>657_bases
ATGGTTATGAAAGAAGGGATTAAAGTGATTGAATATATAAAAAAACCTATGGCAATAGAAGAAAAAAGTTTTGAAATAAT
AGGAAGCGAAATGAAAAGAAAAGATTTTACAAAAGAAGAATTAAAAATAGTTAAAAGAACCATACATACGACAGGGGACT
TTGATTATGAAAATATAGTTTATATAAGAGAAGATGCAATAGAAGAAGCTTTAAAGATACTGAAAAAGGGAGTAACTATT
TATACTGATACTAATATGGCTAAATCAGGAATTAACAAAGCAGCTTTAAAAAAATTAAACTGTACAGTAGAGTGTTTTGT
TTCCAATGAAGAAGTAGCCCAAATTGCTAAGGAAAGAGGAATAACTCGTTCTATGGCAGGAGTTGAAAAGGCAGTAGAAG
ATGGTGTAGAGTTTTTCGTTTTTGGAAATGCACCTACAGCATTATTTAAACTTATAGAATTAACTAAAGAGGGGAAAGCT
AATCCTAAATTTATAATAGGCTCTCCAGTAGGATTTGTTGGGGCAGCAGAATCAAAAGAAGAATTAGAAAAATCATTAGA
TCTACCAATAATTACAGTAAGAGGCAGAAAAGGAGGAAGTAATGTAGCAGCAGCTATTGTAAATGCTCTTATGTATATGA
TAGTAGACAGAGATTAA

Upstream 100 bases:

>100_bases
GGAATTGCGGATATATAAAGGGTAATACCATAGCAGCCTATGCCCATGTAAATTTCCTAGGAAATATAGAATTTTTAAAA
GCTTTATTAGAAAAATAAAA

Downstream 100 bases:

>100_bases
GTAGGTGGAATTTATGTTAGATATGTACGTAATGGTTGATGGTAAAAAATTAAGATGTGGATATACAACAGGATCTTGTG
CTACAGCAGCAGCAAAGGCT

Product: precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MVMKEGIKVIEYIKKPMAIEEKSFEIIGSEMKRKDFTKEELKIVKRTIHTTGDFDYENIVYIREDAIEEALKILKKGVTI
YTDTNMAKSGINKAALKKLNCTVECFVSNEEVAQIAKERGITRSMAGVEKAVEDGVEFFVFGNAPTALFKLIELTKEGKA
NPKFIIGSPVGFVGAAESKEELEKSLDLPIITVRGRKGGSNVAAAIVNALMYMIVDRD

Sequences:

>Translated_218_residues
MVMKEGIKVIEYIKKPMAIEEKSFEIIGSEMKRKDFTKEELKIVKRTIHTTGDFDYENIVYIREDAIEEALKILKKGVTI
YTDTNMAKSGINKAALKKLNCTVECFVSNEEVAQIAKERGITRSMAGVEKAVEDGVEFFVFGNAPTALFKLIELTKEGKA
NPKFIIGSPVGFVGAAESKEELEKSLDLPIITVRGRKGGSNVAAAIVNALMYMIVDRD
>Mature_218_residues
MVMKEGIKVIEYIKKPMAIEEKSFEIIGSEMKRKDFTKEELKIVKRTIHTTGDFDYENIVYIREDAIEEALKILKKGVTI
YTDTNMAKSGINKAALKKLNCTVECFVSNEEVAQIAKERGITRSMAGVEKAVEDGVEFFVFGNAPTALFKLIELTKEGKA
NPKFIIGSPVGFVGAAESKEELEKSLDLPIITVRGRKGGSNVAAAIVNALMYMIVDRD

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 24191; Mature: 24191

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMKEGIKVIEYIKKPMAIEEKSFEIIGSEMKRKDFTKEELKIVKRTIHTTGDFDYENIV
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEE
YIREDAIEEALKILKKGVTIYTDTNMAKSGINKAALKKLNCTVECFVSNEEVAQIAKERG
EEHHHHHHHHHHHHHCCCEEEECCCHHHHCCCHHHHHHHCCEEEEEECCHHHHHHHHHCC
ITRSMAGVEKAVEDGVEFFVFGNAPTALFKLIELTKEGKANPKFIIGSPVGFVGAAESKE
CHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHH
ELEKSLDLPIITVRGRKGGSNVAAAIVNALMYMIVDRD
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVMKEGIKVIEYIKKPMAIEEKSFEIIGSEMKRKDFTKEELKIVKRTIHTTGDFDYENIV
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEE
YIREDAIEEALKILKKGVTIYTDTNMAKSGINKAALKKLNCTVECFVSNEEVAQIAKERG
EEHHHHHHHHHHHHHCCCEEEECCCHHHHCCCHHHHHHHCCEEEEEECCHHHHHHHHHCC
ITRSMAGVEKAVEDGVEFFVFGNAPTALFKLIELTKEGKANPKFIIGSPVGFVGAAESKE
CHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHH
ELEKSLDLPIITVRGRKGGSNVAAAIVNALMYMIVDRD
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8501034; 11677609; 1451790 [H]