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The map label for this gene is cobD [H]

Identifier: 28210443

GI number: 28210443

Start: 748206

End: 749333

Strand: Direct

Name: cobD [H]

Synonym: CTC00722

Alternate gene names: 28210443

Gene position: 748206-749333 (Clockwise)

Preceding gene: 28210442

Following gene: 161486850

Centisome position: 26.73

GC content: 25.8

Gene sequence:

>1128_bases
GTGATGACATTGAGACATGGAGGAGATATATACACTGATGGAATATTAAAAGGAAGGAAACTTATAGATTTTAGCTCTAA
TATAAACCCCCTTGGTATACCAAAAAGTTTTACGGAGAATATACAAGAAGCAATAGATAATTTAAATAAATACCCTGATA
TAAAATATAGAACCTTAAAAGGAAATATAGTAGAATATATAAATAAAAGTAAAGTTTTGTTTCAAAGAGATGAAAAAGTT
ATAGAAAATGGTTATATTGAAATAGTGGATGAAAATTCTATAGTTTTGGGAAATGGAGCAGCAGAAATTATAGATTTAGT
TATTTCTACCTTAAAGAGAATAATGATAATAACACCATCCTTTGGTGAATATGAAGAAAACGCAGAAAAATATGGATGTG
AAATACTTTATGTAAATTCTACAAAAAATATGGACTATGATTATGAAAGTATACTAAACAACCTAAATAGAGTAGATGGA
ATTATATTAGGAAATCCCAACAATCCAGATGGAAGGATTTTAAAAGAGGAAGAATTTAAACCTATATTAGATTACTGTGA
AAAAAATAATAAGTTGGTTATTATAGATGAGGCTTTTATAGAATTCGTAGGAGATATGAGTAAAAGTTATGTAGAAAAAA
TAAAAAATTATAAATGCTTATTTATAATAAGAGCTTTGACAAAATTTTATTCTATGCCTGGAATAAGATTTGGATTTGGG
ATTAGCAGAGATAAAAAAGTTATAGAAGAGATTAAATCTCTGCAAAATCCTTGGAATATAAATGCTTTTGCAGAAGTGGC
AGCAAAATATGTATTAAAGGATAAAGAGTATATAAAAAAATCCCTACAATGGATAACAGAAGAAAGAGAAACTCTTTTAG
AAGAAATAAGAAAGCTAGGTTTTATAGAAAAAGCTTATAATAGCAATGGAAATTTTATACTTTGTAAATTAAAAAATATA
GATTGTGAAGAATTATATGATCTTTGCCTAAAAGAAGATATTGTCATAAGAAAATGTGATAATTACAAGGGATTAGATAA
GTCTTTTGTAAGAGTTGCAATAAAAGATAGACAAACCAATAAAATTTTAATAGATAAATTAAATAAAATATGGAGGGATT
TTAAATGA

Upstream 100 bases:

>100_bases
TACACCATGAACTTATAAACGACAGTGTAAAGCTTATGTATGCTTCAGAGACGCTTATGGTTATTATATATGCTCTTACA
GTTACTAGTTATAATTTGAG

Downstream 100 bases:

>100_bases
AAAAGAATCTAACTTTTTTCATGGTGATTGCACTACTATTTACAATTACCCCAAATGTTTATGCTATGCATATAGCGGAA
GGATTTTTACCACCTATGTG

Product: aminotransferase cobD

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MMTLRHGGDIYTDGILKGRKLIDFSSNINPLGIPKSFTENIQEAIDNLNKYPDIKYRTLKGNIVEYINKSKVLFQRDEKV
IENGYIEIVDENSIVLGNGAAEIIDLVISTLKRIMIITPSFGEYEENAEKYGCEILYVNSTKNMDYDYESILNNLNRVDG
IILGNPNNPDGRILKEEEFKPILDYCEKNNKLVIIDEAFIEFVGDMSKSYVEKIKNYKCLFIIRALTKFYSMPGIRFGFG
ISRDKKVIEEIKSLQNPWNINAFAEVAAKYVLKDKEYIKKSLQWITEERETLLEEIRKLGFIEKAYNSNGNFILCKLKNI
DCEELYDLCLKEDIVIRKCDNYKGLDKSFVRVAIKDRQTNKILIDKLNKIWRDFK

Sequences:

>Translated_375_residues
MMTLRHGGDIYTDGILKGRKLIDFSSNINPLGIPKSFTENIQEAIDNLNKYPDIKYRTLKGNIVEYINKSKVLFQRDEKV
IENGYIEIVDENSIVLGNGAAEIIDLVISTLKRIMIITPSFGEYEENAEKYGCEILYVNSTKNMDYDYESILNNLNRVDG
IILGNPNNPDGRILKEEEFKPILDYCEKNNKLVIIDEAFIEFVGDMSKSYVEKIKNYKCLFIIRALTKFYSMPGIRFGFG
ISRDKKVIEEIKSLQNPWNINAFAEVAAKYVLKDKEYIKKSLQWITEERETLLEEIRKLGFIEKAYNSNGNFILCKLKNI
DCEELYDLCLKEDIVIRKCDNYKGLDKSFVRVAIKDRQTNKILIDKLNKIWRDFK
>Mature_375_residues
MMTLRHGGDIYTDGILKGRKLIDFSSNINPLGIPKSFTENIQEAIDNLNKYPDIKYRTLKGNIVEYINKSKVLFQRDEKV
IENGYIEIVDENSIVLGNGAAEIIDLVISTLKRIMIITPSFGEYEENAEKYGCEILYVNSTKNMDYDYESILNNLNRVDG
IILGNPNNPDGRILKEEEFKPILDYCEKNNKLVIIDEAFIEFVGDMSKSYVEKIKNYKCLFIIRALTKFYSMPGIRFGFG
ISRDKKVIEEIKSLQNPWNINAFAEVAAKYVLKDKEYIKKSLQWITEERETLLEEIRKLGFIEKAYNSNGNFILCKLKNI
DCEELYDLCLKEDIVIRKCDNYKGLDKSFVRVAIKDRQTNKILIDKLNKIWRDFK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=331, Percent_Identity=23.8670694864048, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=23.7467018469657, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 43602; Mature: 43602

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLRHGGDIYTDGILKGRKLIDFSSNINPLGIPKSFTENIQEAIDNLNKYPDIKYRTLK
CCEECCCCCEEECHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEC
GNIVEYINKSKVLFQRDEKVIENGYIEIVDENSIVLGNGAAEIIDLVISTLKRIMIITPS
CHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHEEECCC
FGEYEENAEKYGCEILYVNSTKNMDYDYESILNNLNRVDGIILGNPNNPDGRILKEEEFK
CCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCEEEECCCCCCCCCEECHHCCH
PILDYCEKNNKLVIIDEAFIEFVGDMSKSYVEKIKNYKCLFIIRALTKFYSMPGIRFGFG
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCC
ISRDKKVIEEIKSLQNPWNINAFAEVAAKYVLKDKEYIKKSLQWITEERETLLEEIRKLG
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
FIEKAYNSNGNFILCKLKNIDCEELYDLCLKEDIVIRKCDNYKGLDKSFVRVAIKDRQTN
CHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHEEEEECCCCC
KILIDKLNKIWRDFK
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MMTLRHGGDIYTDGILKGRKLIDFSSNINPLGIPKSFTENIQEAIDNLNKYPDIKYRTLK
CCEECCCCCEEECHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEC
GNIVEYINKSKVLFQRDEKVIENGYIEIVDENSIVLGNGAAEIIDLVISTLKRIMIITPS
CHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHEEECCC
FGEYEENAEKYGCEILYVNSTKNMDYDYESILNNLNRVDGIILGNPNNPDGRILKEEEFK
CCCHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCEEEECCCCCCCCCEECHHCCH
PILDYCEKNNKLVIIDEAFIEFVGDMSKSYVEKIKNYKCLFIIRALTKFYSMPGIRFGFG
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCC
ISRDKKVIEEIKSLQNPWNINAFAEVAAKYVLKDKEYIKKSLQWITEERETLLEEIRKLG
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
FIEKAYNSNGNFILCKLKNIDCEELYDLCLKEDIVIRKCDNYKGLDKSFVRVAIKDRQTN
CHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHEEEEECCCCC
KILIDKLNKIWRDFK
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]