Click here to switch to the map view.

The map label for this gene is glsA

Identifier: 28210302

GI number: 28210302

Start: 584870

End: 585790

Strand: Direct

Name: glsA

Synonym: CTC00566

Alternate gene names: 28210302

Gene position: 584870-585790 (Clockwise)

Preceding gene: 28210301

Following gene: 28210303

Centisome position: 20.89

GC content: 31.27

Gene sequence:

>921_bases
GTGATGCAAAGTAAAATAGAAAGCATAATTGAAGAGTGTAGAAAATATACAAGAGAAGGTGAAGTGGCTTCATATATACC
AGAACTTAAAAAAGCGGATAAAGATGCATTGGGTATATATATAGATAAATTAGATGGTAATGAATTTTGTGCAGGAGACT
ATGATACAAAATTCACAATACAAAGTATATCTAAGATTATCGCTTTAATTATAGCTATAATGGATAATGGCATGGAAAAA
GTATTATCAAAGGTTGGAGTAGAGCCTTCAGCATATTCATTTAATTCAATTGTTACATTAGAAGTAAAAAATGCTAATAA
ACCTTTAAATCCAATGATAAATGCCGGAGCTATAGCTACAGTATCTTTGATAAAAGGAAATAGTCCTGAAGAAATTATAG
AAAGAATATTAGAATTTACAAGGAAAGTTACAGGCAATAAAAACATAAAAGTAAATGAAGAAGTATATCAATCAGAAAAG
AAAACTGGGGATAGGAATAGATCATTAGCATACTTTATGAAGGGAACTGGTATTATTGAAAAGGATGTTGAAAAGGTTTT
AGATGCATATTTCCAACAATGTTCAATAGAAGTCACTTGTAAAGATATAGCTAAAATAGCTTCTTTTTTAGCTAATGATG
GAGTACTTCCTTCTACGGGAGAAAGAATTATACCAGCAGAAGTAGCAAAAATAGTAAAGGCAGTTATGGTTACTTGTGGA
ATGTATGATGCTTCAGGAAGTTTTGCAGTTAAAGTAGGCATACCTTCAAAATCTGGAGTAGGTGGAGGGATACTTGCAAC
AGTTCCTGGAGTAATGGGAATAGGTGTATTTGGTCCAGCTTTAGATAAAAAAGGTAATAGTATAGCAGGAGTTAAGATTT
TAGAGAGACTATCTGAAGAGTTAAATTTAAGCATATTTTAA

Upstream 100 bases:

>100_bases
AAAGTTAAGTATTAACATATAAATAATTTTGAAAATTTGTTTAACCGCATATATGCATATATAATAAAGTTAATAAATAT
GAAGAGTTCGAGGAGGACAA

Downstream 100 bases:

>100_bases
AAAGTTCTTGCTAAAATGAAAAATAAATGATATACTTTGTTTTAAACATAGATACAAGTGAATATAGAAAGGTAGAGGCG
CGGTATTTAATAGTATCTGT

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MMQSKIESIIEECRKYTREGEVASYIPELKKADKDALGIYIDKLDGNEFCAGDYDTKFTIQSISKIIALIIAIMDNGMEK
VLSKVGVEPSAYSFNSIVTLEVKNANKPLNPMINAGAIATVSLIKGNSPEEIIERILEFTRKVTGNKNIKVNEEVYQSEK
KTGDRNRSLAYFMKGTGIIEKDVEKVLDAYFQQCSIEVTCKDIAKIASFLANDGVLPSTGERIIPAEVAKIVKAVMVTCG
MYDASGSFAVKVGIPSKSGVGGGILATVPGVMGIGVFGPALDKKGNSIAGVKILERLSEELNLSIF

Sequences:

>Translated_306_residues
MMQSKIESIIEECRKYTREGEVASYIPELKKADKDALGIYIDKLDGNEFCAGDYDTKFTIQSISKIIALIIAIMDNGMEK
VLSKVGVEPSAYSFNSIVTLEVKNANKPLNPMINAGAIATVSLIKGNSPEEIIERILEFTRKVTGNKNIKVNEEVYQSEK
KTGDRNRSLAYFMKGTGIIEKDVEKVLDAYFQQCSIEVTCKDIAKIASFLANDGVLPSTGERIIPAEVAKIVKAVMVTCG
MYDASGSFAVKVGIPSKSGVGGGILATVPGVMGIGVFGPALDKKGNSIAGVKILERLSEELNLSIF
>Mature_306_residues
MMQSKIESIIEECRKYTREGEVASYIPELKKADKDALGIYIDKLDGNEFCAGDYDTKFTIQSISKIIALIIAIMDNGMEK
VLSKVGVEPSAYSFNSIVTLEVKNANKPLNPMINAGAIATVSLIKGNSPEEIIERILEFTRKVTGNKNIKVNEEVYQSEK
KTGDRNRSLAYFMKGTGIIEKDVEKVLDAYFQQCSIEVTCKDIAKIASFLANDGVLPSTGERIIPAEVAKIVKAVMVTCG
MYDASGSFAVKVGIPSKSGVGGGILATVPGVMGIGVFGPALDKKGNSIAGVKILERLSEELNLSIF

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=306, Percent_Identity=40.5228758169935, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI20336214, Length=305, Percent_Identity=38.6885245901639, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1787804, Length=303, Percent_Identity=39.9339933993399, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI1786693, Length=287, Percent_Identity=39.7212543554007, Blast_Score=225, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17532727, Length=306, Percent_Identity=41.1764705882353, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17507019, Length=306, Percent_Identity=38.8888888888889, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI193204073, Length=309, Percent_Identity=38.8349514563107, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI193204075, Length=311, Percent_Identity=38.5852090032154, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24653162, Length=308, Percent_Identity=39.6103896103896, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281363239, Length=308, Percent_Identity=39.6103896103896, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281363241, Length=308, Percent_Identity=39.6103896103896, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24653164, Length=308, Percent_Identity=39.6103896103896, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24653156, Length=308, Percent_Identity=39.6103896103896, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI116008307, Length=308, Percent_Identity=39.6103896103896, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24653158, Length=308, Percent_Identity=39.6103896103896, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24653166, Length=308, Percent_Identity=39.6103896103896, Blast_Score=231, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_CLOTE (Q898A3)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781246.1
- ProteinModelPortal:   Q898A3
- SMR:   Q898A3
- GeneID:   1060847
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00566
- NMPDR:   fig|212717.1.peg.468
- HOGENOM:   HBG512335
- OMA:   RNASIAY
- PhylomeDB:   Q898A3
- ProtClustDB:   PRK00971
- BioCyc:   CTET212717:CTC_00566-MONOMER
- BRENDA:   3.5.1.2
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33065; Mature: 33065

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQSKIESIIEECRKYTREGEVASYIPELKKADKDALGIYIDKLDGNEFCAGDYDTKFTI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCHHH
QSISKIIALIIAIMDNGMEKVLSKVGVEPSAYSFNSIVTLEVKNANKPLNPMINAGAIAT
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHE
VSLIKGNSPEEIIERILEFTRKVTGNKNIKVNEEVYQSEKKTGDRNRSLAYFMKGTGIIE
EEECCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCCCCEEEEECCCCCHH
KDVEKVLDAYFQQCSIEVTCKDIAKIASFLANDGVLPSTGERIIPAEVAKIVKAVMVTCG
HHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHC
MYDASGSFAVKVGIPSKSGVGGGILATVPGVMGIGVFGPALDKKGNSIAGVKILERLSEE
CEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCHHHHHHHHHHHHH
LNLSIF
CCCCCC
>Mature Secondary Structure
MMQSKIESIIEECRKYTREGEVASYIPELKKADKDALGIYIDKLDGNEFCAGDYDTKFTI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCHHH
QSISKIIALIIAIMDNGMEKVLSKVGVEPSAYSFNSIVTLEVKNANKPLNPMINAGAIAT
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHE
VSLIKGNSPEEIIERILEFTRKVTGNKNIKVNEEVYQSEKKTGDRNRSLAYFMKGTGIIE
EEECCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCCCCEEEEECCCCCHH
KDVEKVLDAYFQQCSIEVTCKDIAKIASFLANDGVLPSTGERIIPAEVAKIVKAVMVTCG
HHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHC
MYDASGSFAVKVGIPSKSGVGGGILATVPGVMGIGVFGPALDKKGNSIAGVKILERLSEE
CEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCHHHHHHHHHHHHH
LNLSIF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129