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The map label for this gene is argH

Identifier: 28210300

GI number: 28210300

Start: 581425

End: 582741

Strand: Direct

Name: argH

Synonym: CTC00562

Alternate gene names: 28210300

Gene position: 581425-582741 (Clockwise)

Preceding gene: 28210299

Following gene: 28210301

Centisome position: 20.77

GC content: 28.17

Gene sequence:

>1317_bases
ATGAAACTTTGGGGTGGAAGATTCAAAGGCGAAGAAAATAAACTTATGGAGGATTTTAATAGTTCTCTAAGTTTTGATAA
AAGACTTTATAAAGAAGATATATTAGGAAGTAAAGCTCATGTAAAAATGCTTGGAAATTGTAATATATTAAAAGATTATG
AAGTTGAAGAAATAATAAAAGGTTTAGATAGTATACTAAAGGATATAGAAGATGATAAGCTGAAAATACAAGGAGAATAT
GAGGATATCCATAGCTTTATTGAAAGTAATTTAATACAAAGAATTGGAGATGTAGGGAAGAAGTTACATACTGCTAGAAG
TAGAAATGACCAAGTAGCAGTAGATTTTAAATTATACGCAAAAAATATTTCCCTAAAAATAATAGAAAGTATAGAAACTC
TTCAAAATACAATAAAAAATTTAGCAGAAAAAAATAATGTTATAATGCCAGGATATACTCATCTTCAAAGAGCCCAAGTA
GTTACCTTTAAACATCACATTATGGCATATTATAATATGCTTAAAAGAGATAAAAAGAGGATAGAAAATTCTATAGAAAA
TATGGATGAAAGCCCACTTGGATGCTGTGCTTTAGCAGGGACAACCTATGAAACAGATAGAAAATTTACTGCAAAAAAAT
TAGGGTTCAGAAAAGAAGTAGATAATTTTCTAGATGGTGTTAGTGATAGAGATTTTGTAATAGAATTTATATCTGATTTT
TCTATAATAATGATGCATTTAAGTAGATTAAGTGAAGAACTTATTTTATGGAGTAGTAAAGAATTTGATTTTATAGAAAT
AAGTGATGAGTTTTCTACCGGAAGTTCAATAATGCCACAAAAGAAGAATCCAGATGCAGCTGAGCTTATAAGAGGTAAAA
CAGGTAGAGTGTATGGAGATTTAATAGCAATATTAACTGTTATGAAAGGAATTCCTCTAGCCTATAATAAGGATATGCAA
GAAGATAAGGAAAGTTTTTTTGATGCTTCAGATACGGTTTTAAGTTGTATTAAAGTTATGGAAGGTATGCTTTCATCGTT
AAAAGTGAAAAAAGGGAACACATTAAGAGCTGTAAAAATGGGATTTTTAAACGCTACAGAGTCAGCGGATTATTTGGTTT
TAAAAGGAGTTCCCTTTAGAGACGCTCATAAAATTATAGGGGAAATTGTACTTTATTGTGAAGAAAAGGACAAATCTATA
GAAGAACTAAATATAAATGAATTAAAAAAATTTAGTACTTTTTTTAATGAAGATATATATGAATTTATAGATTATGAAAA
TGCTTTGAATAGAGGAATAAAAAAGGAGATAAAATAG

Upstream 100 bases:

>100_bases
ATAATATTAAAAATTAAAGGGGCGGTCCTATTAAAAATTAAAAGTTAAAGGATTGTCCCTTATAAAATTAAATAAAAATG
TAATATAAAGGAGGGGTCTT

Downstream 100 bases:

>100_bases
ATAAGACAAGACTTATGCTAAGGTATTGCCATAAGTCTTGTCGTTTCATGTAAACAATTAAATGTTTAATAATTTAATTT
ATTTAGGCAATATCAAAATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKLWGGRFKGEENKLMEDFNSSLSFDKRLYKEDILGSKAHVKMLGNCNILKDYEVEEIIKGLDSILKDIEDDKLKIQGEY
EDIHSFIESNLIQRIGDVGKKLHTARSRNDQVAVDFKLYAKNISLKIIESIETLQNTIKNLAEKNNVIMPGYTHLQRAQV
VTFKHHIMAYYNMLKRDKKRIENSIENMDESPLGCCALAGTTYETDRKFTAKKLGFRKEVDNFLDGVSDRDFVIEFISDF
SIIMMHLSRLSEELILWSSKEFDFIEISDEFSTGSSIMPQKKNPDAAELIRGKTGRVYGDLIAILTVMKGIPLAYNKDMQ
EDKESFFDASDTVLSCIKVMEGMLSSLKVKKGNTLRAVKMGFLNATESADYLVLKGVPFRDAHKIIGEIVLYCEEKDKSI
EELNINELKKFSTFFNEDIYEFIDYENALNRGIKKEIK

Sequences:

>Translated_438_residues
MKLWGGRFKGEENKLMEDFNSSLSFDKRLYKEDILGSKAHVKMLGNCNILKDYEVEEIIKGLDSILKDIEDDKLKIQGEY
EDIHSFIESNLIQRIGDVGKKLHTARSRNDQVAVDFKLYAKNISLKIIESIETLQNTIKNLAEKNNVIMPGYTHLQRAQV
VTFKHHIMAYYNMLKRDKKRIENSIENMDESPLGCCALAGTTYETDRKFTAKKLGFRKEVDNFLDGVSDRDFVIEFISDF
SIIMMHLSRLSEELILWSSKEFDFIEISDEFSTGSSIMPQKKNPDAAELIRGKTGRVYGDLIAILTVMKGIPLAYNKDMQ
EDKESFFDASDTVLSCIKVMEGMLSSLKVKKGNTLRAVKMGFLNATESADYLVLKGVPFRDAHKIIGEIVLYCEEKDKSI
EELNINELKKFSTFFNEDIYEFIDYENALNRGIKKEIK
>Mature_438_residues
MKLWGGRFKGEENKLMEDFNSSLSFDKRLYKEDILGSKAHVKMLGNCNILKDYEVEEIIKGLDSILKDIEDDKLKIQGEY
EDIHSFIESNLIQRIGDVGKKLHTARSRNDQVAVDFKLYAKNISLKIIESIETLQNTIKNLAEKNNVIMPGYTHLQRAQV
VTFKHHIMAYYNMLKRDKKRIENSIENMDESPLGCCALAGTTYETDRKFTAKKLGFRKEVDNFLDGVSDRDFVIEFISDF
SIIMMHLSRLSEELILWSSKEFDFIEISDEFSTGSSIMPQKKNPDAAELIRGKTGRVYGDLIAILTVMKGIPLAYNKDMQ
EDKESFFDASDTVLSCIKVMEGMLSSLKVKKGNTLRAVKMGFLNATESADYLVLKGVPFRDAHKIIGEIVLYCEEKDKSI
EELNINELKKFSTFFNEDIYEFIDYENALNRGIKKEIK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=431, Percent_Identity=40.8352668213457, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI68303542, Length=431, Percent_Identity=40.8352668213457, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI68303549, Length=431, Percent_Identity=39.2111368909513, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI68303547, Length=431, Percent_Identity=38.7470997679814, Blast_Score=321, Evalue=1e-87,
Organism=Escherichia coli, GI1790398, Length=437, Percent_Identity=47.8260869565217, Blast_Score=434, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321806, Length=434, Percent_Identity=43.0875576036866, Blast_Score=356, Evalue=4e-99,
Organism=Drosophila melanogaster, GI221473854, Length=427, Percent_Identity=40.7494145199063, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI78706858, Length=427, Percent_Identity=40.7494145199063, Blast_Score=342, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CLOTE (P59616)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781244.1
- ProteinModelPortal:   P59616
- SMR:   P59616
- GeneID:   1058756
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00562
- NMPDR:   fig|212717.1.peg.466
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   P59616
- ProtClustDB:   PRK00855
- BioCyc:   CTET212717:CTC_00562-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50297; Mature: 50297

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFKGEENKLMEDFNSSLSFDKRLYKEDILGSKAHVKMLGNCNILKDYEVEEIIK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCEECCCCHHHHHH
GLDSILKDIEDDKLKIQGEYEDIHSFIESNLIQRIGDVGKKLHTARSRNDQVAVDFKLYA
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
KNISLKIIESIETLQNTIKNLAEKNNVIMPGYTHLQRAQVVTFKHHIMAYYNMLKRDKKR
CCCHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IENSIENMDESPLGCCALAGTTYETDRKFTAKKLGFRKEVDNFLDGVSDRDFVIEFISDF
HHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
SIIMMHLSRLSEELILWSSKEFDFIEISDEFSTGSSIMPQKKNPDAAELIRGKTGRVYGD
HHHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHH
LIAILTVMKGIPLAYNKDMQEDKESFFDASDTVLSCIKVMEGMLSSLKVKKGNTLRAVKM
HHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
GFLNATESADYLVLKGVPFRDAHKIIGEIVLYCEEKDKSIEELNINELKKFSTFFNEDIY
HHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHH
EFIDYENALNRGIKKEIK
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLWGGRFKGEENKLMEDFNSSLSFDKRLYKEDILGSKAHVKMLGNCNILKDYEVEEIIK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCEECCCCHHHHHH
GLDSILKDIEDDKLKIQGEYEDIHSFIESNLIQRIGDVGKKLHTARSRNDQVAVDFKLYA
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
KNISLKIIESIETLQNTIKNLAEKNNVIMPGYTHLQRAQVVTFKHHIMAYYNMLKRDKKR
CCCHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IENSIENMDESPLGCCALAGTTYETDRKFTAKKLGFRKEVDNFLDGVSDRDFVIEFISDF
HHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
SIIMMHLSRLSEELILWSSKEFDFIEISDEFSTGSSIMPQKKNPDAAELIRGKTGRVYGD
HHHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHH
LIAILTVMKGIPLAYNKDMQEDKESFFDASDTVLSCIKVMEGMLSSLKVKKGNTLRAVKM
HHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
GFLNATESADYLVLKGVPFRDAHKIIGEIVLYCEEKDKSIEELNINELKKFSTFFNEDIY
HHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHH
EFIDYENALNRGIKKEIK
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129