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The map label for this gene is yrbE [H]

Identifier: 28210253

GI number: 28210253

Start: 518780

End: 519802

Strand: Direct

Name: yrbE [H]

Synonym: CTC00511

Alternate gene names: 28210253

Gene position: 518780-519802 (Clockwise)

Preceding gene: 28210252

Following gene: 28210254

Centisome position: 18.53

GC content: 31.18

Gene sequence:

>1023_bases
ATGAAGGTAATGATTAATTTAGGAGTTATTGGATTTGGAAGAATAGGTAAGGTACATGCAGAAAGTTTAACTAAATATGT
TCCTAATGTATCACTTAAAGCTGTAGCAGATCCATTTATGAACGAAGAAGGTATAAATTGTGCAAAATCCATGGGAGTTG
AGAATGCATACAAAGATTATAAGGAAGTATTAAATGATCCAGAAATAGATGCTGTTTTAGTATGTTCATCTACAGATACT
CATTCAAAGATATCTATTGAGGCATTAAAAGCAGGTAAACATGTATTTTGTGAAAAACCAATTGATCATGATATTGAAAG
AATAAAAGAGGTATTAAAGGAAGTTGAAAAATCTAATCTTAAATTTCAAGTAGGTTTTAATAGAAGATTTGATCATAACT
TTAAAACTATTAAGAATACTATAAAAGCGGGTAAAATTGGAGAACCTCATATAATAAAAATAACATCAAGGGACCCAGAA
GCACCTCCAATAGAATATGTAAAAGTTTCAGGTGGAATTTTTTTAGATATGAGCATACATGATTTTGATATGGTTCGTTA
TCTATCTGGAAGTGAGGTAGAAGAAGTATATGCTATAGGGGATGCACTTATAAATCCAGATATAAAGAAGGAAGGGGATG
TAGATACTGCAATAATAACATTAAAATTAGCAAATGGAGCTTTAGGTGTTATAGATAATAGCAGAGAGGCAGCTTATGGC
TACGATCAAAGAGCAGAAGTATTTGGTTCAAAAGGATCAGTTCAAATAAGTAATGATGCTAATTCTACAGCTGTGGTTAG
TACAAAAGATGGTGTAACTGGAGAGAAACCATTATATTTTTTCCTAGAAAGATATATGCAATCTTTTGCTGATGAAATAA
AAGAATTTGTAAAAGCTATAGAAGAAGACAAAGAAGTTCCTGTAACGGCTATAGATGGACTTAATGCAGTATTAATAGGA
ATTGCTGCTACAAAGTCATTAAAAGAAGGAAGAGCAGTTAAGATCTCTGAAATAGGTTTATAA

Upstream 100 bases:

>100_bases
ATCCTAAAATAAATAAAGCGTATGAAAGTAAAATAAACCATTTAGCCAAAGCTAGAAAATATTAAATCAATAATAATTTA
ATTCAAAGATAAAAAAGGGG

Downstream 100 bases:

>100_bases
CAAATCAGATTAAAGGATTGGGGGAAAATTTATGTTTAATAAAGATAAAGTGAAAATTGGAATAGCGCCTATAGCATGGA
CTAATGATGATATGCCAGAA

Product: myo-inositol 2-dehydrogenase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKVMINLGVIGFGRIGKVHAESLTKYVPNVSLKAVADPFMNEEGINCAKSMGVENAYKDYKEVLNDPEIDAVLVCSSTDT
HSKISIEALKAGKHVFCEKPIDHDIERIKEVLKEVEKSNLKFQVGFNRRFDHNFKTIKNTIKAGKIGEPHIIKITSRDPE
APPIEYVKVSGGIFLDMSIHDFDMVRYLSGSEVEEVYAIGDALINPDIKKEGDVDTAIITLKLANGALGVIDNSREAAYG
YDQRAEVFGSKGSVQISNDANSTAVVSTKDGVTGEKPLYFFLERYMQSFADEIKEFVKAIEEDKEVPVTAIDGLNAVLIG
IAATKSLKEGRAVKISEIGL

Sequences:

>Translated_340_residues
MKVMINLGVIGFGRIGKVHAESLTKYVPNVSLKAVADPFMNEEGINCAKSMGVENAYKDYKEVLNDPEIDAVLVCSSTDT
HSKISIEALKAGKHVFCEKPIDHDIERIKEVLKEVEKSNLKFQVGFNRRFDHNFKTIKNTIKAGKIGEPHIIKITSRDPE
APPIEYVKVSGGIFLDMSIHDFDMVRYLSGSEVEEVYAIGDALINPDIKKEGDVDTAIITLKLANGALGVIDNSREAAYG
YDQRAEVFGSKGSVQISNDANSTAVVSTKDGVTGEKPLYFFLERYMQSFADEIKEFVKAIEEDKEVPVTAIDGLNAVLIG
IAATKSLKEGRAVKISEIGL
>Mature_340_residues
MKVMINLGVIGFGRIGKVHAESLTKYVPNVSLKAVADPFMNEEGINCAKSMGVENAYKDYKEVLNDPEIDAVLVCSSTDT
HSKISIEALKAGKHVFCEKPIDHDIERIKEVLKEVEKSNLKFQVGFNRRFDHNFKTIKNTIKAGKIGEPHIIKITSRDPE
APPIEYVKVSGGIFLDMSIHDFDMVRYLSGSEVEEVYAIGDALINPDIKKEGDVDTAIITLKLANGALGVIDNSREAAYG
YDQRAEVFGSKGSVQISNDANSTAVVSTKDGVTGEKPLYFFLERYMQSFADEIKEFVKAIEEDKEVPVTAIDGLNAVLIG
IAATKSLKEGRAVKISEIGL

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=268, Percent_Identity=27.9850746268657, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1789848, Length=144, Percent_Identity=34.0277777777778, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081947, Length=144, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 37320; Mature: 37320

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVMINLGVIGFGRIGKVHAESLTKYVPNVSLKAVADPFMNEEGINCAKSMGVENAYKDY
CEEEEEECEEECCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHCCCCHHHHHH
KEVLNDPEIDAVLVCSSTDTHSKISIEALKAGKHVFCEKPIDHDIERIKEVLKEVEKSNL
HHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCC
KFQVGFNRRFDHNFKTIKNTIKAGKIGEPHIIKITSRDPEAPPIEYVKVSGGIFLDMSIH
EEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEEEC
DFDMVRYLSGSEVEEVYAIGDALINPDIKKEGDVDTAIITLKLANGALGVIDNSREAAYG
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCC
YDQRAEVFGSKGSVQISNDANSTAVVSTKDGVTGEKPLYFFLERYMQSFADEIKEFVKAI
CCCHHHHCCCCCCEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EEDKEVPVTAIDGLNAVLIGIAATKSLKEGRAVKISEIGL
HCCCCCCEEEECCCCEEEEEHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure
MKVMINLGVIGFGRIGKVHAESLTKYVPNVSLKAVADPFMNEEGINCAKSMGVENAYKDY
CEEEEEECEEECCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHCCCCHHHHHH
KEVLNDPEIDAVLVCSSTDTHSKISIEALKAGKHVFCEKPIDHDIERIKEVLKEVEKSNL
HHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCC
KFQVGFNRRFDHNFKTIKNTIKAGKIGEPHIIKITSRDPEAPPIEYVKVSGGIFLDMSIH
EEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEEEC
DFDMVRYLSGSEVEEVYAIGDALINPDIKKEGDVDTAIITLKLANGALGVIDNSREAAYG
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCC
YDQRAEVFGSKGSVQISNDANSTAVVSTKDGVTGEKPLYFFLERYMQSFADEIKEFVKAI
CCCHHHHCCCCCCEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EEDKEVPVTAIDGLNAVLIGIAATKSLKEGRAVKISEIGL
HCCCCCCEEEECCCCEEEEEHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]