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The map label for this gene is lytC [H]

Identifier: 28210246

GI number: 28210246

Start: 510000

End: 511778

Strand: Direct

Name: lytC [H]

Synonym: CTC00504

Alternate gene names: 28210246

Gene position: 510000-511778 (Clockwise)

Preceding gene: 28210245

Following gene: 28210248

Centisome position: 18.22

GC content: 29.74

Gene sequence:

>1779_bases
ATGAACAAAAAAAGAACAATTTTAAACTTACTTGCAACCATAACTATTTCAGTATTTTTATCAGGTGTATGTGTAGAGTC
AAAAGTATCAGCTGCTACTTACTCAAAAAGTGAAAGAATTTGGGGGAAAGATAGATATGAAACAGCAGTAAAGATATCAC
AAAATGGATGGAAAGACGGTGCAAACTGTGTAATATTATCCTCTGGTGAAGGATATGCAGACGCATTATGTGCAGCTCCA
TTAGCTAAAATTAAAGATGCACCTATACTTCTTACAAAAAAAGATACATTAGATTCAAATACTTTAGAAGAATTAAAAAG
ACTTGGAGTTAATAGAGTATATATTGTAGGGGGACAAGGCTCTGTTGCAAAAGAAGTAGAGAACAAAATAAAATCTGAAA
CAAATTCAAAAGTAGAAAGAATAGAAGGAAAAGATAGGTATGAAACATCTATAAAAATTGCAGAAAAATTGGGGACGGTT
AATAAAAATAACCAACCCAAAGAACTAATATTAGCTTCAGGAGAAAATTATGCAGATGCTTTATCAGCAGCACCAGTTGG
AGCTATAAGAGAGATTCCTATTATACTTACAAAATCAAATGAACTTCCAAGTAAAACAAAAGAATATATAAAAAAGTGCA
ATGCAAATAAAACATATGTAATAGGAGGACAAGCTTCTATTAGTAATTCTATAAAAAATTCACTACCAAGAAGTAAAAGA
ATATATGGTAATGATAGATTTGAAACCAATGTAGCTGTAGCAAAGGCATTTCCATCTGATTTTGAATTTAGAAAACCTTA
TGTAGCTCTAGGAGCAGGTTCTACAGGAAATGAATTTGCAGATGCACTTGCAGTATCAGCTTTGGCAGCTAAAAATTCAG
CACCAGTAATTTTAACAGGAAAAAACTTAAGTGATTCAACAGAAACTTTAGCTAAAGAAAACTTTTTACCTTCAAGTAAA
ATTACAGTTTTAGGTGGAATTAATAATGTACCAGAAAAGATAGTACAGGACATAAGAGCTGTAGCAGAACTTATGAATGA
AGAAGAGGGTTTATATGATCAAAATATAGAAGGAAATGCAGCAATTACTGCAAAAGATATAACAGTTAATTATATAACGA
TAAATGGAAACCTATATATAGAAGAAAAGGATGCAGAAATAGTAAAAGTAAAAGTAAATGGAACAATATTTATAAATCCA
GGTGAAAATGGAGAATGTAAATTAGAAGATGTAGAAGCAGATAAAGTAGTAATATTATCAGGAACAGAAAGAGGAATTTT
CTTTAAAGATGTTAGAGCAAATGAGTTAGAACTAAGAAATAAAAATAAAACAAGAGTTGTACTAGAAGAATTATCAAAAT
TTAATAAAACAGAAGTATTAACAGCAACAATTCTTCAAAATGTGGTAGGTTCCTTTGGAGAAGTTACTATAAAGGATACA
TTAAAAGATAAAGATGTAGAACTTCATGGATCATTTCATGAAAAAATAGTATTAGAAGGATCGGTTAACTTAAATGCATT
TCCAGCAAATTATATAGAAAAAATAGAAGTAAAAACAGAAAAAGGTGAAGATATAATGTTGGATGGAGATTGTAGGGAAG
TAGAAGTATATAGTGGAGTTAATATAAAGGTTACAAAAAACACTAAAGGAGACATAATAGCTAAAAGCTTAGAAGCAGAA
AACTATGCAACAATAGATATGCCTAAAAACTTAGATATAAAAGTGAAGAATTTTAAATTGGATAATATAAAAGGCCAAGG
CAAGGAACAGTTTATATAA

Upstream 100 bases:

>100_bases
AACTTAATGAAAATTCTTAAAAGAAAATGCAAATTTTGATTAACCGTCCCCATAGCTTATAATATAATAAAAATTATATA
ACAAAAAAAGGGGGAGAAAA

Downstream 100 bases:

>100_bases
GTTGAGTTTATAAATAAAGAAGAGTTATTAATTTTAAAATAGAAAAGGAGCTGTCTTTTGCATTGATTAAAAAATCATTC
CAAGAGAGCTCCTTTTATAT

Product: cwp66 homolog/N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MNKKRTILNLLATITISVFLSGVCVESKVSAATYSKSERIWGKDRYETAVKISQNGWKDGANCVILSSGEGYADALCAAP
LAKIKDAPILLTKKDTLDSNTLEELKRLGVNRVYIVGGQGSVAKEVENKIKSETNSKVERIEGKDRYETSIKIAEKLGTV
NKNNQPKELILASGENYADALSAAPVGAIREIPIILTKSNELPSKTKEYIKKCNANKTYVIGGQASISNSIKNSLPRSKR
IYGNDRFETNVAVAKAFPSDFEFRKPYVALGAGSTGNEFADALAVSALAAKNSAPVILTGKNLSDSTETLAKENFLPSSK
ITVLGGINNVPEKIVQDIRAVAELMNEEEGLYDQNIEGNAAITAKDITVNYITINGNLYIEEKDAEIVKVKVNGTIFINP
GENGECKLEDVEADKVVILSGTERGIFFKDVRANELELRNKNKTRVVLEELSKFNKTEVLTATILQNVVGSFGEVTIKDT
LKDKDVELHGSFHEKIVLEGSVNLNAFPANYIEKIEVKTEKGEDIMLDGDCREVEVYSGVNIKVTKNTKGDIIAKSLEAE
NYATIDMPKNLDIKVKNFKLDNIKGQGKEQFI

Sequences:

>Translated_592_residues
MNKKRTILNLLATITISVFLSGVCVESKVSAATYSKSERIWGKDRYETAVKISQNGWKDGANCVILSSGEGYADALCAAP
LAKIKDAPILLTKKDTLDSNTLEELKRLGVNRVYIVGGQGSVAKEVENKIKSETNSKVERIEGKDRYETSIKIAEKLGTV
NKNNQPKELILASGENYADALSAAPVGAIREIPIILTKSNELPSKTKEYIKKCNANKTYVIGGQASISNSIKNSLPRSKR
IYGNDRFETNVAVAKAFPSDFEFRKPYVALGAGSTGNEFADALAVSALAAKNSAPVILTGKNLSDSTETLAKENFLPSSK
ITVLGGINNVPEKIVQDIRAVAELMNEEEGLYDQNIEGNAAITAKDITVNYITINGNLYIEEKDAEIVKVKVNGTIFINP
GENGECKLEDVEADKVVILSGTERGIFFKDVRANELELRNKNKTRVVLEELSKFNKTEVLTATILQNVVGSFGEVTIKDT
LKDKDVELHGSFHEKIVLEGSVNLNAFPANYIEKIEVKTEKGEDIMLDGDCREVEVYSGVNIKVTKNTKGDIIAKSLEAE
NYATIDMPKNLDIKVKNFKLDNIKGQGKEQFI
>Mature_592_residues
MNKKRTILNLLATITISVFLSGVCVESKVSAATYSKSERIWGKDRYETAVKISQNGWKDGANCVILSSGEGYADALCAAP
LAKIKDAPILLTKKDTLDSNTLEELKRLGVNRVYIVGGQGSVAKEVENKIKSETNSKVERIEGKDRYETSIKIAEKLGTV
NKNNQPKELILASGENYADALSAAPVGAIREIPIILTKSNELPSKTKEYIKKCNANKTYVIGGQASISNSIKNSLPRSKR
IYGNDRFETNVAVAKAFPSDFEFRKPYVALGAGSTGNEFADALAVSALAAKNSAPVILTGKNLSDSTETLAKENFLPSSK
ITVLGGINNVPEKIVQDIRAVAELMNEEEGLYDQNIEGNAAITAKDITVNYITINGNLYIEEKDAEIVKVKVNGTIFINP
GENGECKLEDVEADKVVILSGTERGIFFKDVRANELELRNKNKTRVVLEELSKFNKTEVLTATILQNVVGSFGEVTIKDT
LKDKDVELHGSFHEKIVLEGSVNLNAFPANYIEKIEVKTEKGEDIMLDGDCREVEVYSGVNIKVTKNTKGDIIAKSLEAE
NYATIDMPKNLDIKVKNFKLDNIKGQGKEQFI

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 64775; Mature: 64775

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKRTILNLLATITISVFLSGVCVESKVSAATYSKSERIWGKDRYETAVKISQNGWKDG
CCCHHHHHHHHHHHHHHHHHHCCEECCCCCHHHCCCCCCCCCCCCCEEEEEEECCCCCCC
ANCVILSSGEGYADALCAAPLAKIKDAPILLTKKDTLDSNTLEELKRLGVNRVYIVGGQG
CCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCC
SVAKEVENKIKSETNSKVERIEGKDRYETSIKIAEKLGTVNKNNQPKELILASGENYADA
CHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHH
LSAAPVGAIREIPIILTKSNELPSKTKEYIKKCNANKTYVIGGQASISNSIKNSLPRSKR
HHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCC
IYGNDRFETNVAVAKAFPSDFEFRKPYVALGAGSTGNEFADALAVSALAAKNSAPVILTG
CCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEC
KNLSDSTETLAKENFLPSSKITVLGGINNVPEKIVQDIRAVAELMNEEEGLYDQNIEGNA
CCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
AITAKDITVNYITINGNLYIEEKDAEIVKVKVNGTIFINPGENGECKLEDVEADKVVILS
EEEEEEEEEEEEEEECEEEEEECCCEEEEEEECEEEEECCCCCCCEEEEECCCCEEEEEE
GTERGIFFKDVRANELELRNKNKTRVVLEELSKFNKTEVLTATILQNVVGSFGEVTIKDT
CCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEC
LKDKDVELHGSFHEKIVLEGSVNLNAFPANYIEKIEVKTEKGEDIMLDGDCREVEVYSGV
CCCCCEEECCCCCEEEEEECCCCCEECCCCHHEEEEEEECCCCEEEECCCCCEEEEECCC
NIKVTKNTKGDIIAKSLEAENYATIDMPKNLDIKVKNFKLDNIKGQGKEQFI
EEEEECCCCCCEEEEECCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNKKRTILNLLATITISVFLSGVCVESKVSAATYSKSERIWGKDRYETAVKISQNGWKDG
CCCHHHHHHHHHHHHHHHHHHCCEECCCCCHHHCCCCCCCCCCCCCEEEEEEECCCCCCC
ANCVILSSGEGYADALCAAPLAKIKDAPILLTKKDTLDSNTLEELKRLGVNRVYIVGGQG
CCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCC
SVAKEVENKIKSETNSKVERIEGKDRYETSIKIAEKLGTVNKNNQPKELILASGENYADA
CHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHH
LSAAPVGAIREIPIILTKSNELPSKTKEYIKKCNANKTYVIGGQASISNSIKNSLPRSKR
HHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCC
IYGNDRFETNVAVAKAFPSDFEFRKPYVALGAGSTGNEFADALAVSALAAKNSAPVILTG
CCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEC
KNLSDSTETLAKENFLPSSKITVLGGINNVPEKIVQDIRAVAELMNEEEGLYDQNIEGNA
CCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
AITAKDITVNYITINGNLYIEEKDAEIVKVKVNGTIFINPGENGECKLEDVEADKVVILS
EEEEEEEEEEEEEEECEEEEEECCCEEEEEEECEEEEECCCCCCCEEEEECCCCEEEEEE
GTERGIFFKDVRANELELRNKNKTRVVLEELSKFNKTEVLTATILQNVVGSFGEVTIKDT
CCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEC
LKDKDVELHGSFHEKIVLEGSVNLNAFPANYIEKIEVKTEKGEDIMLDGDCREVEVYSGV
CCCCCEEECCCCCEEEEEECCCCCEECCCCHHEEEEEEECCCCEEEECCCCCEEEEECCC
NIKVTKNTKGDIIAKSLEAENYATIDMPKNLDIKVKNFKLDNIKGQGKEQFI
EEEEECCCCCCEEEEECCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]