Click here to switch to the map view.

The map label for this gene is dhaT [H]

Identifier: 28210248

GI number: 28210248

Start: 512896

End: 514050

Strand: Direct

Name: dhaT [H]

Synonym: CTC00506

Alternate gene names: 28210248

Gene position: 512896-514050 (Clockwise)

Preceding gene: 28210246

Following gene: 28210249

Centisome position: 18.32

GC content: 30.91

Gene sequence:

>1155_bases
ATGGCATATAAAATTAATATTCCTGGAAATATTATATATGGAAAGAATGCTCTGAAGGAATCATCAAAAAACATAAAAGA
GCTAGGAGGAAAAGCTTTAATAGTTACTGATAAAATAATGATTGAAATAGGTAATGTTAAAAAAGTCAGTGAAGTTCTTG
ATGATATTGGTATAAAATATGAAATATATGACGGAATTAATTCAGAACCTACAGACGTAATGGTAGATAAAGGAATAGAA
ATATATAATAATTCTCATTGTGATTTTTTAATTGCTATAGGAGGAGGAAGTCCTATAGATGCTTCAAAGGCAATTGGAGC
TATGATAACAAATTTAGGAAATATAAATGACTACATGGGAAAAATAATAGAAAATGCCTCGCCAAGCATTGTAGCAATTC
CAACCACTGCTGGAACAGGATCAGAAGCAACCGAATTTACAATCATATCAAATACAAAAGACAACATAAAAATGTTGCTA
AAAGGAAAAAGTTTAATTCCTACTTTGGCAATAGTTGACCCGCAATTTTCTATAACAGTACCCCAAAACATTACGGCAAC
TACAGGAATAGATGCTTTGACGCACGCCATTGAATCATATACATCAAAACATGCAAATTCATTTTCAGATACCTTCGCAC
TATCAGCAGTAAAGCGTATTTTTAATAATTTAATAAAAGCATATAAAGATGGGAAGAATTTTGAAGCTAGAAATGAAATG
GCTCTAGGTGCCTTAGAAGCAGGAATTGCTTTTAATAATTCTTCGGTAACTATAGTTCATGGAATGAGTAGACCAATTGG
AGCTTTATTTAAAGTACCACATGGGCTTTCTAATGCAGTACTTTTACCCAAATGTTTAGAATTTGCAATTCAAGGGGAAG
AAAAAAGATTTGCAGATATTGCAAAAGCAATAGAAATATGTAAAGAAGAAACATCAGATAAAGAAGCTGCAGAAAAACTT
GTAAAAGAAATTGAAAGTTTGTGCAAAGATATTAATATACCAACCTTGGAGGAGTACGGTATAGAAAAAAATGAATTTTA
TGAAGAAATAAATAAGATGGCAGAAGATGCATTAAATAGTGGAAGTCCTGCAAATACTAGACGACAACCTACTAAAGAAG
ATATTGTTAATATATATAAACAGTTGTATATATAA

Upstream 100 bases:

>100_bases
AATTAAATGATAGAATGTAATCAAAAGTTAACCATAAGATGGGAATATATAATCATAAATGTATCAATATGTACTATTGA
TTTGAAATGGAGGGGGATTA

Downstream 100 bases:

>100_bases
AGAATTGAGAAGTTAAAGTTCTTATATTCCTAATATGGTTTTGAGAAAAAGGAGTAAATATCATGTCGATTGTAAAAATG
AAACAACTTTTAAAAAATGC

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MAYKINIPGNIIYGKNALKESSKNIKELGGKALIVTDKIMIEIGNVKKVSEVLDDIGIKYEIYDGINSEPTDVMVDKGIE
IYNNSHCDFLIAIGGGSPIDASKAIGAMITNLGNINDYMGKIIENASPSIVAIPTTAGTGSEATEFTIISNTKDNIKMLL
KGKSLIPTLAIVDPQFSITVPQNITATTGIDALTHAIESYTSKHANSFSDTFALSAVKRIFNNLIKAYKDGKNFEARNEM
ALGALEAGIAFNNSSVTIVHGMSRPIGALFKVPHGLSNAVLLPKCLEFAIQGEEKRFADIAKAIEICKEETSDKEAAEKL
VKEIESLCKDINIPTLEEYGIEKNEFYEEINKMAEDALNSGSPANTRRQPTKEDIVNIYKQLYI

Sequences:

>Translated_384_residues
MAYKINIPGNIIYGKNALKESSKNIKELGGKALIVTDKIMIEIGNVKKVSEVLDDIGIKYEIYDGINSEPTDVMVDKGIE
IYNNSHCDFLIAIGGGSPIDASKAIGAMITNLGNINDYMGKIIENASPSIVAIPTTAGTGSEATEFTIISNTKDNIKMLL
KGKSLIPTLAIVDPQFSITVPQNITATTGIDALTHAIESYTSKHANSFSDTFALSAVKRIFNNLIKAYKDGKNFEARNEM
ALGALEAGIAFNNSSVTIVHGMSRPIGALFKVPHGLSNAVLLPKCLEFAIQGEEKRFADIAKAIEICKEETSDKEAAEKL
VKEIESLCKDINIPTLEEYGIEKNEFYEEINKMAEDALNSGSPANTRRQPTKEDIVNIYKQLYI
>Mature_383_residues
AYKINIPGNIIYGKNALKESSKNIKELGGKALIVTDKIMIEIGNVKKVSEVLDDIGIKYEIYDGINSEPTDVMVDKGIEI
YNNSHCDFLIAIGGGSPIDASKAIGAMITNLGNINDYMGKIIENASPSIVAIPTTAGTGSEATEFTIISNTKDNIKMLLK
GKSLIPTLAIVDPQFSITVPQNITATTGIDALTHAIESYTSKHANSFSDTFALSAVKRIFNNLIKAYKDGKNFEARNEMA
LGALEAGIAFNNSSVTIVHGMSRPIGALFKVPHGLSNAVLLPKCLEFAIQGEEKRFADIAKAIEICKEETSDKEAAEKLV
KEIESLCKDINIPTLEEYGIEKNEFYEEINKMAEDALNSGSPANTRRQPTKEDIVNIYKQLYI

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=364, Percent_Identity=28.8461538461538, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=37.037037037037, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1789163, Length=391, Percent_Identity=35.5498721227622, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=31.7460317460317, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1787493, Length=409, Percent_Identity=30.3178484107579, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789386, Length=377, Percent_Identity=24.1379310344828, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17537053, Length=390, Percent_Identity=27.9487179487179, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=382, Percent_Identity=37.434554973822, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24657991, Length=345, Percent_Identity=30.4347826086957, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41775; Mature: 41644

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKINIPGNIIYGKNALKESSKNIKELGGKALIVTDKIMIEIGNVKKVSEVLDDIGIKY
CEEEEECCCEEEECCHHHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHHHCCCEE
EIYDGINSEPTDVMVDKGIEIYNNSHCDFLIAIGGGSPIDASKAIGAMITNLGNINDYMG
EEECCCCCCCCCEEECCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHH
KIIENASPSIVAIPTTAGTGSEATEFTIISNTKDNIKMLLKGKSLIPTLAIVDPQFSITV
HHHCCCCCCEEEEECCCCCCCCCEEEEEEECCCHHHHEEECCCCCCCEEEEECCCEEEEC
PQNITATTGIDALTHAIESYTSKHANSFSDTFALSAVKRIFNNLIKAYKDGKNFEARNEM
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALGALEAGIAFNNSSVTIVHGMSRPIGALFKVPHGLSNAVLLPKCLEFAIQGEEKRFADI
HHHHHHHCEEECCCCEEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHH
AKAIEICKEETSDKEAAEKLVKEIESLCKDINIPTLEEYGIEKNEFYEEINKMAEDALNS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
GSPANTRRQPTKEDIVNIYKQLYI
CCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AYKINIPGNIIYGKNALKESSKNIKELGGKALIVTDKIMIEIGNVKKVSEVLDDIGIKY
EEEEECCCEEEECCHHHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHHHCCCEE
EIYDGINSEPTDVMVDKGIEIYNNSHCDFLIAIGGGSPIDASKAIGAMITNLGNINDYMG
EEECCCCCCCCCEEECCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHH
KIIENASPSIVAIPTTAGTGSEATEFTIISNTKDNIKMLLKGKSLIPTLAIVDPQFSITV
HHHCCCCCCEEEEECCCCCCCCCEEEEEEECCCHHHHEEECCCCCCCEEEEECCCEEEEC
PQNITATTGIDALTHAIESYTSKHANSFSDTFALSAVKRIFNNLIKAYKDGKNFEARNEM
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALGALEAGIAFNNSSVTIVHGMSRPIGALFKVPHGLSNAVLLPKCLEFAIQGEEKRFADI
HHHHHHHCEEECCCCEEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHH
AKAIEICKEETSDKEAAEKLVKEIESLCKDINIPTLEEYGIEKNEFYEEINKMAEDALNS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
GSPANTRRQPTKEDIVNIYKQLYI
CCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]