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The map label for this gene is yisQ [H]

Identifier: 28210196

GI number: 28210196

Start: 440378

End: 441748

Strand: Direct

Name: yisQ [H]

Synonym: CTC00443

Alternate gene names: 28210196

Gene position: 440378-441748 (Clockwise)

Preceding gene: 28210195

Following gene: 28210197

Centisome position: 15.73

GC content: 30.2

Gene sequence:

>1371_bases
TTGGAAAACACATTGAAAGGAAAAGTTAACAATAGTGAATTTTATAAGGTTTTAGGTAGACTAGCCCTACCAATAATAAT
TCAAAATTTCATAACAGCTTTTTTAAATATGGTAGATACAGTTATGGTTGGAAAATTGGGAGAAGTTGAAATAGCATCTG
TAGGTGTAGCAAACCAATATTTCTTTTTCTTTAACCTTCTCGCACTTGGAATATCTAGTGGTGGAGGAATATTTATCTCT
CAGTTTTGGGGAAAAAGAGATGAAAAGAACATAAGAAAAATATTAGGAGTAAATGTTATAGCAGGTGTTACAATATCATT
GTTAATGACTTTAATAGCTTTATTAATGCCAGAAACTATAATATCTTTATTTAATAAAGATCCTCAAGTTATACACTTTG
GAGCAAAGTATTTAAAAACTATAGCTATAAGCTATATACTTACTGCTATAACTTTAGCATATAGTATATCATTAAGATGT
ATTGGAGAAGCCATAATACCAATGGCTATAAGCGGAATTGCATTAATAACTAACATATTCTTTAACTATGGATTAATATT
TGGTAATTTTGGATTACCAGCATTAGGAGTTAAGGGAGCGGCTTTAGCCACTGTAATTGCCAGATTAGTGGAATGTGTAG
CACTTTTAATATATGTATACAGTAAAAAAGGTGTTTTAGCAGCATCCATAAAAGAAATGACAGATATAAATATGAAATTT
ATAAATAAAATATATAGAACTATAGCTAGCGTACTATTTAATGAAGCTTGTTGGGGACTAGCCATGGTTATGTATGCAGC
TATATATGGAAGGATAGGTACAAAGGCAATTGCATCAATACAAATATGTACTACAGTACAAAATTTATTTATGGTAGTAA
CATTAGGAGTAGCAAATGCTTCAGCAGTTATGATAGGAAATAAAATAGGCGAAGGAAAAGAAGAAGAAGGAAAGGAATAT
GCTAAAAAGTTTACCAAAATGGGTATAATACTTGGGATAATATTAGGTGTTTCCATGGCAATAAGTGCACCATTTATACT
AAATTTATTTAATGTATCACAAGAAGTAATGAGATCCTCTTTACTTATACTATATATAACCTCCATCATAATGGTAATGA
GAGTATTTAATGCTGTTATGATAGTAGGAGTTCTAAGAGGTGGAGGAGACGCAAAATATGCATTAATCTCAGAAGCGGTA
ACTATGTGGCTTGTAGGACTTCCTTTAACTTTAATAGCAGCTTTTATAATAAAATTACCTGTTTATGTAGTAGCTGGTAT
GGCAGGCATAGAGGAATTTGGAAAGTTTATATTAAGTTATAAGAGAGTTAAATCAAATAAATGGATAAAAAACGTAATTT
ATAATCTATAA

Upstream 100 bases:

>100_bases
CAAAAATATATAGATTAGTGATGAAGCGAACCACTTTGAAAAACTTCTAGGGGTTTGCTTTTAATTTTCAGATATATTTT
AGGAGAAAGGAGAGATTTTA

Downstream 100 bases:

>100_bases
ATTTTGTTTTGTAGGCTCGTTTGCTTCGCTAAACATCGCTGTTTTAGTTAAGAACTACTTAATATATAAATCAGATAATT
AAAATTTTTTCGTAATGATA

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MENTLKGKVNNSEFYKVLGRLALPIIIQNFITAFLNMVDTVMVGKLGEVEIASVGVANQYFFFFNLLALGISSGGGIFIS
QFWGKRDEKNIRKILGVNVIAGVTISLLMTLIALLMPETIISLFNKDPQVIHFGAKYLKTIAISYILTAITLAYSISLRC
IGEAIIPMAISGIALITNIFFNYGLIFGNFGLPALGVKGAALATVIARLVECVALLIYVYSKKGVLAASIKEMTDINMKF
INKIYRTIASVLFNEACWGLAMVMYAAIYGRIGTKAIASIQICTTVQNLFMVVTLGVANASAVMIGNKIGEGKEEEGKEY
AKKFTKMGIILGIILGVSMAISAPFILNLFNVSQEVMRSSLLILYITSIIMVMRVFNAVMIVGVLRGGGDAKYALISEAV
TMWLVGLPLTLIAAFIIKLPVYVVAGMAGIEEFGKFILSYKRVKSNKWIKNVIYNL

Sequences:

>Translated_456_residues
MENTLKGKVNNSEFYKVLGRLALPIIIQNFITAFLNMVDTVMVGKLGEVEIASVGVANQYFFFFNLLALGISSGGGIFIS
QFWGKRDEKNIRKILGVNVIAGVTISLLMTLIALLMPETIISLFNKDPQVIHFGAKYLKTIAISYILTAITLAYSISLRC
IGEAIIPMAISGIALITNIFFNYGLIFGNFGLPALGVKGAALATVIARLVECVALLIYVYSKKGVLAASIKEMTDINMKF
INKIYRTIASVLFNEACWGLAMVMYAAIYGRIGTKAIASIQICTTVQNLFMVVTLGVANASAVMIGNKIGEGKEEEGKEY
AKKFTKMGIILGIILGVSMAISAPFILNLFNVSQEVMRSSLLILYITSIIMVMRVFNAVMIVGVLRGGGDAKYALISEAV
TMWLVGLPLTLIAAFIIKLPVYVVAGMAGIEEFGKFILSYKRVKSNKWIKNVIYNL
>Mature_456_residues
MENTLKGKVNNSEFYKVLGRLALPIIIQNFITAFLNMVDTVMVGKLGEVEIASVGVANQYFFFFNLLALGISSGGGIFIS
QFWGKRDEKNIRKILGVNVIAGVTISLLMTLIALLMPETIISLFNKDPQVIHFGAKYLKTIAISYILTAITLAYSISLRC
IGEAIIPMAISGIALITNIFFNYGLIFGNFGLPALGVKGAALATVIARLVECVALLIYVYSKKGVLAASIKEMTDINMKF
INKIYRTIASVLFNEACWGLAMVMYAAIYGRIGTKAIASIQICTTVQNLFMVVTLGVANASAVMIGNKIGEGKEEEGKEY
AKKFTKMGIILGIILGVSMAISAPFILNLFNVSQEVMRSSLLILYITSIIMVMRVFNAVMIVGVLRGGGDAKYALISEAV
TMWLVGLPLTLIAAFIIKLPVYVVAGMAGIEEFGKFILSYKRVKSNKWIKNVIYNL

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=412, Percent_Identity=23.0582524271845, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38261960, Length=441, Percent_Identity=22.4489795918367, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI226510954, Length=414, Percent_Identity=26.0869565217391, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI48994890, Length=440, Percent_Identity=24.3181818181818, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49674; Mature: 49674

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTLKGKVNNSEFYKVLGRLALPIIIQNFITAFLNMVDTVMVGKLGEVEIASVGVANQY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
FFFFNLLALGISSGGGIFISQFWGKRDEKNIRKILGVNVIAGVTISLLMTLIALLMPETI
HHHHHHHHHHCCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISLFNKDPQVIHFGAKYLKTIAISYILTAITLAYSISLRCIGEAIIPMAISGIALITNIF
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNYGLIFGNFGLPALGVKGAALATVIARLVECVALLIYVYSKKGVLAASIKEMTDINMKF
HHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHH
INKIYRTIASVLFNEACWGLAMVMYAAIYGRIGTKAIASIQICTTVQNLFMVVTLGVANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAVMIGNKIGEGKEEEGKEYAKKFTKMGIILGIILGVSMAISAPFILNLFNVSQEVMRSS
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLILYITSIIMVMRVFNAVMIVGVLRGGGDAKYALISEAVTMWLVGLPLTLIAAFIIKLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYVVAGMAGIEEFGKFILSYKRVKSNKWIKNVIYNL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MENTLKGKVNNSEFYKVLGRLALPIIIQNFITAFLNMVDTVMVGKLGEVEIASVGVANQY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
FFFFNLLALGISSGGGIFISQFWGKRDEKNIRKILGVNVIAGVTISLLMTLIALLMPETI
HHHHHHHHHHCCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISLFNKDPQVIHFGAKYLKTIAISYILTAITLAYSISLRCIGEAIIPMAISGIALITNIF
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNYGLIFGNFGLPALGVKGAALATVIARLVECVALLIYVYSKKGVLAASIKEMTDINMKF
HHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHH
INKIYRTIASVLFNEACWGLAMVMYAAIYGRIGTKAIASIQICTTVQNLFMVVTLGVANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAVMIGNKIGEGKEEEGKEYAKKFTKMGIILGIILGVSMAISAPFILNLFNVSQEVMRSS
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLILYITSIIMVMRVFNAVMIVGVLRGGGDAKYALISEAVTMWLVGLPLTLIAAFIIKLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYVVAGMAGIEEFGKFILSYKRVKSNKWIKNVIYNL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]