Click here to switch to the map view.

The map label for this gene is manR [H]

Identifier: 28210040

GI number: 28210040

Start: 254876

End: 256828

Strand: Direct

Name: manR [H]

Synonym: CTC00277

Alternate gene names: 28210040

Gene position: 254876-256828 (Clockwise)

Preceding gene: 28210039

Following gene: 28210041

Centisome position: 9.11

GC content: 25.81

Gene sequence:

>1953_bases
ATGCCTATTATAAAGAAAAAATATGGAGAGGGTATAAAGATAGATTTAACTAAAAATCAAATAGATTTATTAGCCACTAA
AGAATCCATATATAGAAATTATTTAGGCTTTGAGAATAAATATAGATTAATATTATATCTGTTAAAAAGTCACTATTCTA
GAACACTTCAAGAGATATCTAATTTTCTAGGAGTTAGTAGGTCAACTACATCAAAATATCTAGATGAAATAGAGGGATAT
CTTAGAGAAAAAGGTGTACAGTTAGTAAGAAGAAGGAATAAAGGCATTTATATTGTAGGTAGAGAACTGCAAAAAAGAAG
AATCATATATGATATAATTTTACACAGTTACGATTACTCTAGAATACACGGATTATTACAACCAGAAACTATATATGATC
TTATGATATGGAATTACTTTTATGGTATAGATATAAAGCATATATGGGAGCTTTTAATAGATACATTGAAGGCTATAAAT
ATATCTGTATCAGATATGGCTTTTTATAATATTATTATAAATACATGTATAATGATAAAAAGAATACAACAAGATTTTAT
AGCGGATATAGAATACGAAAAAATGGACTATATATCAGAGACTTTTGAATATGACGAAGCCAAAAATTATTGTAATGAAT
TATCTAAAAGATATAATATTATTATACCTAAAACGGAAATAATATGGATAAGTATGCATTTTCTTGGAGCTAATCCTATA
AAGTTTTTAGAAGATGATATTTTTTCAAATATAAAAGAAAGACATAAATTAGTAAATTCTATAGAAAAGATGGTTTCCCA
ATTTGAAAAAGAAGTAGATATAGCTTTAGAAAATAAAGATGAAATCATAAATGGACTTTTTGTTCATTTAATGCCTGCCA
TTAATAGAGCTAAATATAGCATAAAAATAAAAAACTCTTATAAAGAAGATATTAAAAATTCCTATAATGAATTTTATACA
ATTACTGCTAATTTAGTGAGAATAATAAATAACGAGTTTAATGTGGAATTAGGTAGCGATGAAATATCTTATGTTTGCCT
TCATTTTGTAGCTGCAATTGAAAAAATGAATAAAAGTTACGCTACTAAAAAAAGAATTATAGTGGTCTGCTCCACAGGAG
TAGGGACTTCTAAGCTTTTAGCAAATAAACTAAGAAATAGCTATGATGATATAGAAATTATAGACATATTATCTTATAAT
CAGTTTATTTCTAGAAATACCTTTGATATAGATTATGTAATAAGTACAGTAGCTTTAAAAGAGGCTAATGTTCCAGTTAT
AGTAGTAAATCCTCTAATAAATGACGAAGATAAAAAACAGCTTTCTAAGATATTTTCACCAAAAGTAAAAGAAAAGATTA
TAAATGTAGAAAGTATTATAAATGTAGTACAAAAGCATTGCGTAATAAAAGATTTAACCGCACTAAAAAAAGATTTAAAG
AAGAACATAATTGGGGAAATACAAGATGAAATGTTACATATTCGGGATTTGCTAGTATGTGAGGCTATTATTACCAATGT
AGAAGTTACAGATGCAAAAGAGGCTATAAAAATATCAGGTAATGCATTAAAACAATTAGGATACGTTAATGATAATTATG
TAAAGAGTTTAGTAAATTGTTTAAATAAAAGAGGTAAAAATGGCCCTTATATAGTAATATCACATGGTATAGCATTGCCT
CATGCTAAACCAGAAGATGGTGTATATAAAACTGGATTTTCAATGGTTATATTAAAAGAACCAGTAAAATTTAATCATAA
AAAGCATGACCCAGTTCAAGTAATAATAAGTTTTGCAACCAAAAATAATCAAGAGCATGTAAAAGCTCTTGAGGAGATTA
CAAGTTTTATTATGTTAAGAAAAAACTTTAAAAATTTAATTCAATGTAAAGATTCAAAAGAAGTAATATTGTTATTAGAA
AATTTTAAGGAGGAAGGAGAATGCTCAATATAG

Upstream 100 bases:

>100_bases
CAAATATCAAATAAAACAAATATCAAATAAAGTAAATATTAGCGAAAGAACGGTTAGGTATGCTATAGATAATATAAATT
ATATATTAAAGAGAAATAAT

Downstream 100 bases:

>100_bases
TTATTGTATGTAGCTTAGGATTGGGCAGCAGCTTTATAATAGAAGCTAATGTTAAAAGATATTTTAAAAATAAAAAATTA
AAGCATAATATAATTAGATG

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MPIIKKKYGEGIKIDLTKNQIDLLATKESIYRNYLGFENKYRLILYLLKSHYSRTLQEISNFLGVSRSTTSKYLDEIEGY
LREKGVQLVRRRNKGIYIVGRELQKRRIIYDIILHSYDYSRIHGLLQPETIYDLMIWNYFYGIDIKHIWELLIDTLKAIN
ISVSDMAFYNIIINTCIMIKRIQQDFIADIEYEKMDYISETFEYDEAKNYCNELSKRYNIIIPKTEIIWISMHFLGANPI
KFLEDDIFSNIKERHKLVNSIEKMVSQFEKEVDIALENKDEIINGLFVHLMPAINRAKYSIKIKNSYKEDIKNSYNEFYT
ITANLVRIINNEFNVELGSDEISYVCLHFVAAIEKMNKSYATKKRIIVVCSTGVGTSKLLANKLRNSYDDIEIIDILSYN
QFISRNTFDIDYVISTVALKEANVPVIVVNPLINDEDKKQLSKIFSPKVKEKIINVESIINVVQKHCVIKDLTALKKDLK
KNIIGEIQDEMLHIRDLLVCEAIITNVEVTDAKEAIKISGNALKQLGYVNDNYVKSLVNCLNKRGKNGPYIVISHGIALP
HAKPEDGVYKTGFSMVILKEPVKFNHKKHDPVQVIISFATKNNQEHVKALEEITSFIMLRKNFKNLIQCKDSKEVILLLE
NFKEEGECSI

Sequences:

>Translated_650_residues
MPIIKKKYGEGIKIDLTKNQIDLLATKESIYRNYLGFENKYRLILYLLKSHYSRTLQEISNFLGVSRSTTSKYLDEIEGY
LREKGVQLVRRRNKGIYIVGRELQKRRIIYDIILHSYDYSRIHGLLQPETIYDLMIWNYFYGIDIKHIWELLIDTLKAIN
ISVSDMAFYNIIINTCIMIKRIQQDFIADIEYEKMDYISETFEYDEAKNYCNELSKRYNIIIPKTEIIWISMHFLGANPI
KFLEDDIFSNIKERHKLVNSIEKMVSQFEKEVDIALENKDEIINGLFVHLMPAINRAKYSIKIKNSYKEDIKNSYNEFYT
ITANLVRIINNEFNVELGSDEISYVCLHFVAAIEKMNKSYATKKRIIVVCSTGVGTSKLLANKLRNSYDDIEIIDILSYN
QFISRNTFDIDYVISTVALKEANVPVIVVNPLINDEDKKQLSKIFSPKVKEKIINVESIINVVQKHCVIKDLTALKKDLK
KNIIGEIQDEMLHIRDLLVCEAIITNVEVTDAKEAIKISGNALKQLGYVNDNYVKSLVNCLNKRGKNGPYIVISHGIALP
HAKPEDGVYKTGFSMVILKEPVKFNHKKHDPVQVIISFATKNNQEHVKALEEITSFIMLRKNFKNLIQCKDSKEVILLLE
NFKEEGECSI
>Mature_649_residues
PIIKKKYGEGIKIDLTKNQIDLLATKESIYRNYLGFENKYRLILYLLKSHYSRTLQEISNFLGVSRSTTSKYLDEIEGYL
REKGVQLVRRRNKGIYIVGRELQKRRIIYDIILHSYDYSRIHGLLQPETIYDLMIWNYFYGIDIKHIWELLIDTLKAINI
SVSDMAFYNIIINTCIMIKRIQQDFIADIEYEKMDYISETFEYDEAKNYCNELSKRYNIIIPKTEIIWISMHFLGANPIK
FLEDDIFSNIKERHKLVNSIEKMVSQFEKEVDIALENKDEIINGLFVHLMPAINRAKYSIKIKNSYKEDIKNSYNEFYTI
TANLVRIINNEFNVELGSDEISYVCLHFVAAIEKMNKSYATKKRIIVVCSTGVGTSKLLANKLRNSYDDIEIIDILSYNQ
FISRNTFDIDYVISTVALKEANVPVIVVNPLINDEDKKQLSKIFSPKVKEKIINVESIINVVQKHCVIKDLTALKKDLKK
NIIGEIQDEMLHIRDLLVCEAIITNVEVTDAKEAIKISGNALKQLGYVNDNYVKSLVNCLNKRGKNGPYIVISHGIALPH
AKPEDGVYKTGFSMVILKEPVKFNHKKHDPVQVIISFATKNNQEHVKALEEITSFIMLRKNFKNLIQCKDSKEVILLLEN
FKEEGECSI

Specific function: May regulate the expression of the mannose operon [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI2367359, Length=151, Percent_Identity=33.7748344370861, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1790755, Length=111, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789302, Length=101, Percent_Identity=31.6831683168317, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790027, Length=285, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF00359 PTS_EIIA_2 [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 75420; Mature: 75289

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIKKKYGEGIKIDLTKNQIDLLATKESIYRNYLGFENKYRLILYLLKSHYSRTLQEIS
CCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
NFLGVSRSTTSKYLDEIEGYLREKGVQLVRRRNKGIYIVGRELQKRRIIYDIILHSYDYS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCHH
RIHGLLQPETIYDLMIWNYFYGIDIKHIWELLIDTLKAINISVSDMAFYNIIINTCIMIK
HHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RIQQDFIADIEYEKMDYISETFEYDEAKNYCNELSKRYNIIIPKTEIIWISMHFLGANPI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEEEECCCCHH
KFLEDDIFSNIKERHKLVNSIEKMVSQFEKEVDIALENKDEIINGLFVHLMPAINRAKYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHCCCEEE
IKIKNSYKEDIKNSYNEFYTITANLVRIINNEFNVELGSDEISYVCLHFVAAIEKMNKSY
EEECCCHHHHHHHHHHHEEEHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
ATKKRIIVVCSTGVGTSKLLANKLRNSYDDIEIIDILSYNQFISRNTFDIDYVISTVALK
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHC
EANVPVIVVNPLINDEDKKQLSKIFSPKVKEKIINVESIINVVQKHCVIKDLTALKKDLK
CCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
KNIIGEIQDEMLHIRDLLVCEAIITNVEVTDAKEAIKISGNALKQLGYVNDNYVKSLVNC
HHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHEECCHHHHHHCCCCHHHHHHHHHH
LNKRGKNGPYIVISHGIALPHAKPEDGVYKTGFSMVILKEPVKFNHKKHDPVQVIISFAT
HHHCCCCCCEEEEECCEECCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCHHHHEEEHHH
KNNQEHVKALEEITSFIMLRKNFKNLIQCKDSKEVILLLENFKEEGECSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
PIIKKKYGEGIKIDLTKNQIDLLATKESIYRNYLGFENKYRLILYLLKSHYSRTLQEIS
CCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
NFLGVSRSTTSKYLDEIEGYLREKGVQLVRRRNKGIYIVGRELQKRRIIYDIILHSYDYS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCHH
RIHGLLQPETIYDLMIWNYFYGIDIKHIWELLIDTLKAINISVSDMAFYNIIINTCIMIK
HHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RIQQDFIADIEYEKMDYISETFEYDEAKNYCNELSKRYNIIIPKTEIIWISMHFLGANPI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEEEECCCCHH
KFLEDDIFSNIKERHKLVNSIEKMVSQFEKEVDIALENKDEIINGLFVHLMPAINRAKYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHCCCEEE
IKIKNSYKEDIKNSYNEFYTITANLVRIINNEFNVELGSDEISYVCLHFVAAIEKMNKSY
EEECCCHHHHHHHHHHHEEEHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
ATKKRIIVVCSTGVGTSKLLANKLRNSYDDIEIIDILSYNQFISRNTFDIDYVISTVALK
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHC
EANVPVIVVNPLINDEDKKQLSKIFSPKVKEKIINVESIINVVQKHCVIKDLTALKKDLK
CCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
KNIIGEIQDEMLHIRDLLVCEAIITNVEVTDAKEAIKISGNALKQLGYVNDNYVKSLVNC
HHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHEECCHHHHHHCCCCHHHHHHHHHH
LNKRGKNGPYIVISHGIALPHAKPEDGVYKTGFSMVILKEPVKFNHKKHDPVQVIISFAT
HHHCCCCCCEEEEECCEECCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCHHHHEEEHHH
KNNQEHVKALEEITSFIMLRKNFKNLIQCKDSKEVILLLENFKEEGECSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]