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The map label for this gene is gpsA

Identifier: 161486845

GI number: 161486845

Start: 1203927

End: 1204922

Strand: Direct

Name: gpsA

Synonym: CTC01139

Alternate gene names: 161486845

Gene position: 1203927-1204922 (Clockwise)

Preceding gene: 28210831

Following gene: 28210833

Centisome position: 43.01

GC content: 32.43

Gene sequence:

>996_bases
ATGACAATTAAAGGTATAACTTTTATTGGAGGAGGAAGTTTTGGTACTGCTTTAGGTATTATGTTAGCCAAAAAGGGTTA
TAACATAAATATATGGGATAGAAAACCCCATGTGATAGCAGATATAAACGAAAAAAAAGAAAATATAAAATATCTTCCCA
ATGTGGTTATTCCATCAAATGTAAAAGCCTATAAAGGTATGAAAGAGGCTTTAGTGGGAATTAAATATGTAGTTATTTCT
GTACCATCTCATGCTATAAGAGAAATATGCAGAAATATGAAAGATTACTTAAAAGAAGATGCTATTATAATAAGTGTGGC
AAAGGGTATAGAAGAACATAGTGGAAAAAGGTTATCTCAAATTATAAAAGAAGAATTACCTAAAAATCCTGTGGTAATAC
TTTCAGGACCAAGTCATGCAGAAGAAGTAGCACAAGATATACCAACTACTGTAGTAGTTACATCAGAAGATGTTAAGGCA
TCTTTAGAAGTACAGAATTTATTTAGTACAAATAAATTTAGAGTATACACTAATGATGATATAATAGGTGTTGAAATAGG
AGGGGCAGTGAAGAATATAATTGCTTTAGCTGCTGGTATCTCCGATGGAATAGGATATGGAGATAATACAAAAGCTGCTC
TTATGACTAGAGGAATAAATGAGATAATAAGAATTGGAGAAAAGTTAGGAGGACAAAGGGAAACCTTTTGGGGGCTAACA
GGTATGGGGGATATGATAGTAACCTGTACTAGTATGCATAGTAGAAATAGAAGAGCTGGTCTTTTAATAGGAAAAGGTTT
ATCTATGGAAGAGGCTATAGAAGAAGTAGGCATGGTGGTAGAAGGTATAAAAGCTTGTAAAGCCTTTTATGAATTAAAGG
AAAAGTTAAAAGTATCTATGCCCATAACGGATGCTTTATATAGAGTTCTATTTCAAGGGGAAGATGCTAAATACTGTGTA
TATGAATTGATGACTAGAGACAAAAAAGATGAATAA

Upstream 100 bases:

>100_bases
CATTTCTCCTATGAAAGGTATTTAGAAAATCAACTAAGACAAAGCTTTGATTTTACAGGAACAGGAATTAAAATGGAGTT
TAGAGAAAGGAAAGAGTAAT

Downstream 100 bases:

>100_bases
ATTTAATCTTATATTTTAAAGTAATCTGTAGAAATTAAAATTTCTACAGATTACTTTTTTTATATGTAATATTTAAGGGG
GAAGCAAAATATATATATAC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTIKGITFIGGGSFGTALGIMLAKKGYNINIWDRKPHVIADINEKKENIKYLPNVVIPSNVKAYKGMKEALVGIKYVVIS
VPSHAIREICRNMKDYLKEDAIIISVAKGIEEHSGKRLSQIIKEELPKNPVVILSGPSHAEEVAQDIPTTVVVTSEDVKA
SLEVQNLFSTNKFRVYTNDDIIGVEIGGAVKNIIALAAGISDGIGYGDNTKAALMTRGINEIIRIGEKLGGQRETFWGLT
GMGDMIVTCTSMHSRNRRAGLLIGKGLSMEEAIEEVGMVVEGIKACKAFYELKEKLKVSMPITDALYRVLFQGEDAKYCV
YELMTRDKKDE

Sequences:

>Translated_331_residues
MTIKGITFIGGGSFGTALGIMLAKKGYNINIWDRKPHVIADINEKKENIKYLPNVVIPSNVKAYKGMKEALVGIKYVVIS
VPSHAIREICRNMKDYLKEDAIIISVAKGIEEHSGKRLSQIIKEELPKNPVVILSGPSHAEEVAQDIPTTVVVTSEDVKA
SLEVQNLFSTNKFRVYTNDDIIGVEIGGAVKNIIALAAGISDGIGYGDNTKAALMTRGINEIIRIGEKLGGQRETFWGLT
GMGDMIVTCTSMHSRNRRAGLLIGKGLSMEEAIEEVGMVVEGIKACKAFYELKEKLKVSMPITDALYRVLFQGEDAKYCV
YELMTRDKKDE
>Mature_330_residues
TIKGITFIGGGSFGTALGIMLAKKGYNINIWDRKPHVIADINEKKENIKYLPNVVIPSNVKAYKGMKEALVGIKYVVISV
PSHAIREICRNMKDYLKEDAIIISVAKGIEEHSGKRLSQIIKEELPKNPVVILSGPSHAEEVAQDIPTTVVVTSEDVKAS
LEVQNLFSTNKFRVYTNDDIIGVEIGGAVKNIIALAAGISDGIGYGDNTKAALMTRGINEIIRIGEKLGGQRETFWGLTG
MGDMIVTCTSMHSRNRRAGLLIGKGLSMEEAIEEVGMVVEGIKACKAFYELKEKLKVSMPITDALYRVLFQGEDAKYCVY
ELMTRDKKDE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=336, Percent_Identity=29.4642857142857, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI24307999, Length=329, Percent_Identity=31.306990881459, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1790037, Length=328, Percent_Identity=40.2439024390244, Blast_Score=283, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI32564399, Length=333, Percent_Identity=32.1321321321321, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564403, Length=342, Percent_Identity=31.5789473684211, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI193210136, Length=342, Percent_Identity=31.5789473684211, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17507425, Length=349, Percent_Identity=28.9398280802292, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193210134, Length=330, Percent_Identity=28.1818181818182, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320181, Length=339, Percent_Identity=28.9085545722714, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324513, Length=362, Percent_Identity=28.1767955801105, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136204, Length=278, Percent_Identity=34.5323741007194, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17136202, Length=278, Percent_Identity=34.5323741007194, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17136200, Length=278, Percent_Identity=34.5323741007194, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI22026922, Length=326, Percent_Identity=28.5276073619632, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24648969, Length=247, Percent_Identity=28.3400809716599, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551945, Length=247, Percent_Identity=28.3400809716599, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281362270, Length=247, Percent_Identity=28.3400809716599, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_CLOTE (Q895X7)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781776.2
- ProteinModelPortal:   Q895X7
- SMR:   Q895X7
- GeneID:   1060552
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01139
- NMPDR:   fig|212717.1.peg.998
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q895X7
- ProtClustDB:   PRK00094
- BioCyc:   CTET212717:CTC_01139-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36356; Mature: 36225

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 209-209 BINDING 126-126 BINDING 126-126 BINDING 158-158 BINDING 273-273 BINDING 299-299

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKGITFIGGGSFGTALGIMLAKKGYNINIWDRKPHVIADINEKKENIKYLPNVVIPSN
CCEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCEEEECCCHHHHHHHCCCEECCCC
VKAYKGMKEALVGIKYVVISVPSHAIREICRNMKDYLKEDAIIISVAKGIEEHSGKRLSQ
CHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCHHHHH
IIKEELPKNPVVILSGPSHAEEVAQDIPTTVVVTSEDVKASLEVQNLFSTNKFRVYTNDD
HHHHHCCCCCEEEEECCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
IIGVEIGGAVKNIIALAAGISDGIGYGDNTKAALMTRGINEIIRIGEKLGGQRETFWGLT
EEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
GMGDMIVTCTSMHSRNRRAGLLIGKGLSMEEAIEEVGMVVEGIKACKAFYELKEKLKVSM
CCCCHHEEEHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
PITDALYRVLFQGEDAKYCVYELMTRDKKDE
CHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TIKGITFIGGGSFGTALGIMLAKKGYNINIWDRKPHVIADINEKKENIKYLPNVVIPSN
CEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCEEEECCCHHHHHHHCCCEECCCC
VKAYKGMKEALVGIKYVVISVPSHAIREICRNMKDYLKEDAIIISVAKGIEEHSGKRLSQ
CHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCHHHHH
IIKEELPKNPVVILSGPSHAEEVAQDIPTTVVVTSEDVKASLEVQNLFSTNKFRVYTNDD
HHHHHCCCCCEEEEECCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
IIGVEIGGAVKNIIALAAGISDGIGYGDNTKAALMTRGINEIIRIGEKLGGQRETFWGLT
EEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
GMGDMIVTCTSMHSRNRRAGLLIGKGLSMEEAIEEVGMVVEGIKACKAFYELKEKLKVSM
CCCCHHEEEHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
PITDALYRVLFQGEDAKYCVYELMTRDKKDE
CHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129